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Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways

Arnica montana L. (Arnica) has a long history of use in treating inflammation and soft tissue injury, yet its immunomodulatory mechanisms remain largely unexplored. In this study, we investigated the effects of distinct Arnica extracts - derived from different plant parts (root or whole plant) and m...

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Hauptverfasser: Berschneider, Karina M. (VerfasserIn) , Wetterauer, Bernhard (VerfasserIn) , Sticht, Carsten (VerfasserIn) , Orlik, Christian (VerfasserIn) , Jahraus, Beate (VerfasserIn) , Kirchgessner, Henning (VerfasserIn) , Ratushniak, Anastasiia (VerfasserIn) , Wölfl, Stefan (VerfasserIn) , Lairikyengbam, Divya (VerfasserIn) , Beier, Verena (VerfasserIn) , Wabnitz, Guido H. (VerfasserIn) , Link, Pille (VerfasserIn) , Schmiech, Michael (VerfasserIn) , Samstag, Yvonne (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 October 2025
In: Frontiers in immunology
Year: 2025, Jahrgang: 16, Pages: 1-26
ISSN:1664-3224
DOI:10.3389/fimmu.2025.1655212
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fimmu.2025.1655212
Verlag, kostenfrei, Volltext: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1655212/full
Volltext
Verfasserangaben:Karina M. Berschneider, Bernhard Wetterauer, Carsten Sticht, Christian Orlik, Beate Jahraus, Henning Kirchgessner, Anastasiia Zuieva, Stefan Wölfl, Divya Lairikyengbam, Verena Beier, Guido Wabnitz, Pille Wetterauer, Michael Schmiech and Yvonne Samstag
Beschreibung
Zusammenfassung:Arnica montana L. (Arnica) has a long history of use in treating inflammation and soft tissue injury, yet its immunomodulatory mechanisms remain largely unexplored. In this study, we investigated the effects of distinct Arnica extracts - derived from different plant parts (root or whole plant) and manufacturing processes - on primary human T cells. We also compared their effects with those of the pure compounds helenalin and thymol. All extracts inhibited T cell activation and proliferation. This could be traced back to reduced IL-2 responsiveness due to decreased CD25 (IL-2Rα chain) expression, accompanied by reduced IL-2 production. Transcriptomic analysis (nCounter) and gene set enrichment revealed that the extracts target key T cell receptor (TCR) signaling pathways. Mechanistically, the hydroethanolic root extract selectively inhibited NFκB DNA binding, while the aqueous fermented extract predominantly suppressed NFAT-dependent gene expression. The hydroethanolic whole plant extract exerted a moderate effect on both pathways. These findings identify Arnica extracts as promising modulators of human TCR signaling and support their potential in regulating T cell-driven inflammatory responses, with implications for muscle healing and chronic inflammatory diseases.
Beschreibung:Veröffentlicht: 15. Oktober 2025
Gesehen am 02.12.2025
Beschreibung:Online Resource
ISSN:1664-3224
DOI:10.3389/fimmu.2025.1655212

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