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A novel complex of nucleoporins, which Includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores

In a genetic screen for nucleoporin-interacting components, a novel nuclear pore protein Nup84p, which exhibits homology to mammalian Nup107p, was isolated. Nup84p forms a complex with five proteins, of which Nup120p, Nup85p, Sec13p, and a Sec13p homolog were identified. Upon isolation of Sec13p-Pro...

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Hauptverfasser: Siniossoglou, Symeon (VerfasserIn) , Wimmer, Christian (VerfasserIn) , Rieger, Michael (VerfasserIn) , Doye, Valerie (VerfasserIn) , Tekotte, Hildegard (VerfasserIn) , Weise, Chris (VerfasserIn) , Emig, Sonja (VerfasserIn) , Segref, Alexandra (VerfasserIn) , Hurt, Ed (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 26 January 1996
In: Cell
Year: 1996, Jahrgang: 84, Heft: 2, Pages: 265-275
ISSN:1097-4172
DOI:10.1016/S0092-8674(00)80981-2
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0092-8674(00)80981-2
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0092867400809812
Volltext
Verfasserangaben:Symeon Siniossoglou, Christian Wimmer, Michael Rieger, Valerie Doye, Hildegard Tekotte, Chris Weise, Sonja Emig, Alexandra Segref, and Edward C. Hurt
Beschreibung
Zusammenfassung:In a genetic screen for nucleoporin-interacting components, a novel nuclear pore protein Nup84p, which exhibits homology to mammalian Nup107p, was isolated. Nup84p forms a complex with five proteins, of which Nup120p, Nup85p, Sec13p, and a Sec13p homolog were identified. Upon isolation of Sec13p-ProtA, nucleoporins were still associated, but the major copurifying band was a 150 kDa protein, showing that Sec13p occurs in two complexes. Disruption of any of the genes encoding Nup84p, Nup85p, or Nup120p caused defects in nuclear membrane and nuclear pore complex organization, as well as in poly(A)+ RNA transport. Thus, the Nup84p complex in conjunction with Sec13-type proteins is required for correct nuclear pore biogenesis.
Beschreibung:Elektronische Reproduktion der Druck-Ausgabe 27. Juli 2004
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Beschreibung:Online Resource
ISSN:1097-4172
DOI:10.1016/S0092-8674(00)80981-2

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