Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans
In the mammalian brain, the directed motion of cerebrospinal fluid (CSF-flux) is instrumental in the distribution and removal of solutes. Changes in total cerebral blood volume (CBV) have been hypothesized to drive CSF-flux. We tested this hypothesis in two multimodal brain imaging experiments in he...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 24, 2025
|
| Ausgabe: | Version 2 |
| In: |
PLoS biology
Year: 2025, Jahrgang: 23, Heft: 4, Pages: 1-19 |
| ISSN: | 1545-7885 |
| DOI: | 10.1371/journal.pbio.3003138 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1371/journal.pbio.3003138 Verlag, kostenfrei, Volltext: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003138 
|
| Verfasserangaben: | Juliana Zimmermann, Clara Boudriot, Christiane Eipert, Gabriel Hoffmann, Rachel Nuttall, Viktor Neumaier, Moritz Bonhoeffer, Sebastian Schneider, Lena Schmitzer, Jan Kufer, Stephan Kaczmarz, Dennis M. Hedderich, Andreas Ranft, Daniel Golkowski, Josef Priller, Claus Zimmer, Rüdiger Ilg, Gerhard Schneider, Christine Preibisch, Christian Sorg, Benedikt Zott |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1943789320 | ||
| 003 | DE-627 | ||
| 005 | 20251204153959.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251203s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pbio.3003138 |2 doi | |
| 035 | |a (DE-627)1943789320 | ||
| 035 | |a (DE-599)KXP1943789320 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zimmermann, Juliana |e VerfasserIn |0 (DE-588)1383309949 |0 (DE-627)1943787336 |4 aut | |
| 245 | 1 | 0 | |a Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans |c Juliana Zimmermann, Clara Boudriot, Christiane Eipert, Gabriel Hoffmann, Rachel Nuttall, Viktor Neumaier, Moritz Bonhoeffer, Sebastian Schneider, Lena Schmitzer, Jan Kufer, Stephan Kaczmarz, Dennis M. Hedderich, Andreas Ranft, Daniel Golkowski, Josef Priller, Claus Zimmer, Rüdiger Ilg, Gerhard Schneider, Christine Preibisch, Christian Sorg, Benedikt Zott |
| 250 | |a Version 2 | ||
| 264 | 1 | |c April 24, 2025 | |
| 300 | |a 19 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.12.2025 | ||
| 520 | |a In the mammalian brain, the directed motion of cerebrospinal fluid (CSF-flux) is instrumental in the distribution and removal of solutes. Changes in total cerebral blood volume (CBV) have been hypothesized to drive CSF-flux. We tested this hypothesis in two multimodal brain imaging experiments in healthy humans, in which we drove large changes in total CBV by neuronal burst-suppression under anesthesia or by transient global vasodilation in a hypercapnic challenge. We indirectly monitored CBV changes with a high temporal resolution based on associated changes in total brain volume by functional MRI (fMRI) and measured cerebral blood flow by arterial spin-labeling. Relating CBV-sensitive signals to fMRI-derived measures of macroscopic CSF flow across the basal cisternae, we demonstrate that increasing total CBV extrudes CSF from the skull and decreasing CBV allows its influx. Moreover, CSF largely stagnates when CBV is stable. Together, our results establish the direct coupling between total CBV changes and CSF-flux. | ||
| 650 | 4 | |a Anesthesia | |
| 650 | 4 | |a Central nervous system | |
| 650 | 4 | |a Cerebral blood flow assay | |
| 650 | 4 | |a Cerebrospinal fluid | |
| 650 | 4 | |a Coronary heart disease | |
| 650 | 4 | |a Electroencephalography | |
| 650 | 4 | |a Functional magnetic resonance imaging | |
| 650 | 4 | |a Hypercapnia | |
| 700 | 1 | |a Boudriot, Clara |e VerfasserIn |4 aut | |
| 700 | 1 | |a Eipert, Christiane |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hoffmann, Gabriel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nuttall, Rachel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Neumaier, Viktor |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bonhoeffer, Moritz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schneider, Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmitzer, Lena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kufer, Jan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kaczmarz, Stephan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hedderich, Dennis M. |d 1986- |e VerfasserIn |0 (DE-588)1160110719 |0 (DE-627)1023267934 |0 (DE-576)505526395 |4 aut | |
| 700 | 1 | |a Ranft, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Golkowski, Daniel |d 1983- |e VerfasserIn |0 (DE-588)1026152402 |0 (DE-627)72619820X |0 (DE-576)37142500X |4 aut | |
| 700 | 1 | |a Priller, Josef |e VerfasserIn |0 (DE-588)1334315051 |0 (DE-627)1892425211 |4 aut | |
| 700 | 1 | |a Zimmer, Claus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ilg, Rüdiger |d 1973- |e VerfasserIn |0 (DE-588)12908235X |0 (DE-627)388712988 |0 (DE-576)297484613 |4 aut | |
| 700 | 1 | |a Schneider, Gerhard |d 1967- |e VerfasserIn |0 (DE-588)131569430 |0 (DE-627)510986617 |0 (DE-576)298592835 |4 aut | |
| 700 | 1 | |a Preibisch, Christine |d 1970- |e VerfasserIn |0 (DE-588)122448154 |0 (DE-627)705911454 |0 (DE-576)293275548 |4 aut | |
| 700 | 1 | |a Sorg, Christian |d 1969- |e VerfasserIn |0 (DE-588)141754443 |0 (DE-627)631180974 |0 (DE-576)325757607 |4 aut | |
| 700 | 1 | |a Zott, Benedikt |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a Public Library of Science |t PLoS biology |d Lawrence, KS : PLoS, 2003 |g 23(2025), 4, Artikel-ID e3003138, Seite 1-19 |h Online-Ressource |w (DE-627)373755597 |w (DE-600)2126773-X |w (DE-576)109104846 |x 1545-7885 |7 nnas |
| 773 | 1 | 8 | |g volume:23 |g year:2025 |g number:4 |g elocationid:e3003138 |g pages:1-19 |g extent:19 |a Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans |
| 856 | 4 | 0 | |u https://doi.org/10.1371/journal.pbio.3003138 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003138 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20251203 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1026152402 |a Golkowski, Daniel |m 1026152402:Golkowski, Daniel |d 910000 |d 911100 |d 50000 |e 910000PG1026152402 |e 911100PG1026152402 |e 50000PG1026152402 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 14 | ||
| 999 | |a KXP-PPN1943789320 |e 4820042688 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Juliana Zimmermann, Clara Boudriot, Christiane Eipert, Gabriel Hoffmann, Rachel Nuttall, Viktor Neumaier, Moritz Bonhoeffer, Sebastian Schneider, Lena Schmitzer, Jan Kufer, Stephan Kaczmarz, Dennis M. Hedderich, Andreas Ranft, Daniel Golkowski, Josef Priller, Claus Zimmer, Rüdiger Ilg, Gerhard Schneider, Christine Preibisch, Christian Sorg, Benedikt Zott"]},"origin":[{"dateIssuedDisp":"April 24, 2025","dateIssuedKey":"2025","edition":"Version 2"}],"id":{"eki":["1943789320"],"doi":["10.1371/journal.pbio.3003138"]},"physDesc":[{"extent":"19 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2126773-X"],"eki":["373755597"],"issn":["1545-7885"]},"origin":[{"dateIssuedDisp":"2003-","dateIssuedKey":"2003","publisher":"PLoS","publisherPlace":"Lawrence, KS"}],"name":{"displayForm":["Public Library of Science"]},"part":{"extent":"19","text":"23(2025), 4, Artikel-ID e3003138, Seite 1-19","volume":"23","issue":"4","pages":"1-19","year":"2025"},"titleAlt":[{"title":"Biology"}],"pubHistory":["1.2003 -"],"recId":"373755597","language":["eng"],"corporate":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Public Library of Science"}],"disp":"Public Library of SciencePLoS biology","note":["Gesehen am 25.08.20"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"PLoS biology","title_sort":"PLoS biology"}]}],"person":[{"role":"aut","display":"Zimmermann, Juliana","roleDisplay":"VerfasserIn","given":"Juliana","family":"Zimmermann"},{"family":"Boudriot","given":"Clara","roleDisplay":"VerfasserIn","display":"Boudriot, Clara","role":"aut"},{"role":"aut","display":"Eipert, Christiane","roleDisplay":"VerfasserIn","given":"Christiane","family":"Eipert"},{"role":"aut","display":"Hoffmann, Gabriel","roleDisplay":"VerfasserIn","given":"Gabriel","family":"Hoffmann"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Nuttall, Rachel","given":"Rachel","family":"Nuttall"},{"given":"Viktor","family":"Neumaier","role":"aut","roleDisplay":"VerfasserIn","display":"Neumaier, Viktor"},{"given":"Moritz","family":"Bonhoeffer","role":"aut","roleDisplay":"VerfasserIn","display":"Bonhoeffer, Moritz"},{"display":"Schneider, Sebastian","roleDisplay":"VerfasserIn","role":"aut","family":"Schneider","given":"Sebastian"},{"family":"Schmitzer","given":"Lena","display":"Schmitzer, Lena","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Jan","family":"Kufer","role":"aut","display":"Kufer, Jan","roleDisplay":"VerfasserIn"},{"display":"Kaczmarz, Stephan","roleDisplay":"VerfasserIn","role":"aut","family":"Kaczmarz","given":"Stephan"},{"given":"Dennis M.","family":"Hedderich","role":"aut","roleDisplay":"VerfasserIn","display":"Hedderich, Dennis M."},{"roleDisplay":"VerfasserIn","display":"Ranft, Andreas","role":"aut","family":"Ranft","given":"Andreas"},{"given":"Daniel","family":"Golkowski","role":"aut","roleDisplay":"VerfasserIn","display":"Golkowski, Daniel"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Priller, Josef","given":"Josef","family":"Priller"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Zimmer, Claus","given":"Claus","family":"Zimmer"},{"given":"Rüdiger","family":"Ilg","role":"aut","roleDisplay":"VerfasserIn","display":"Ilg, Rüdiger"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Schneider, Gerhard","given":"Gerhard","family":"Schneider"},{"given":"Christine","family":"Preibisch","role":"aut","roleDisplay":"VerfasserIn","display":"Preibisch, Christine"},{"family":"Sorg","given":"Christian","display":"Sorg, Christian","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Zott, Benedikt","given":"Benedikt","family":"Zott"}],"title":[{"title_sort":"Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans","title":"Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans"}],"note":["Gesehen am 03.12.2025"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"1943789320"} | ||
| SRT | |a ZIMMERMANNTOTALCEREB2420 | ||