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Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans

In the mammalian brain, the directed motion of cerebrospinal fluid (CSF-flux) is instrumental in the distribution and removal of solutes. Changes in total cerebral blood volume (CBV) have been hypothesized to drive CSF-flux. We tested this hypothesis in two multimodal brain imaging experiments in he...

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Main Authors: Zimmermann, Juliana (Author) , Boudriot, Clara (Author) , Eipert, Christiane (Author) , Hoffmann, Gabriel (Author) , Nuttall, Rachel (Author) , Neumaier, Viktor (Author) , Bonhoeffer, Moritz (Author) , Schneider, Sebastian (Author) , Schmitzer, Lena (Author) , Kufer, Jan (Author) , Kaczmarz, Stephan (Author) , Hedderich, Dennis M. (Author) , Ranft, Andreas (Author) , Golkowski, Daniel (Author) , Priller, Josef (Author) , Zimmer, Claus (Author) , Ilg, Rüdiger (Author) , Schneider, Gerhard (Author) , Preibisch, Christine (Author) , Sorg, Christian (Author) , Zott, Benedikt (Author)
Format: Article (Journal)
Language:English
Published: April 24, 2025
Edition:Version 2
In: PLoS biology
Year: 2025, Volume: 23, Issue: 4, Pages: 1-19
ISSN:1545-7885
DOI:10.1371/journal.pbio.3003138
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1371/journal.pbio.3003138
Verlag, kostenfrei, Volltext: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003138
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Author Notes:Juliana Zimmermann, Clara Boudriot, Christiane Eipert, Gabriel Hoffmann, Rachel Nuttall, Viktor Neumaier, Moritz Bonhoeffer, Sebastian Schneider, Lena Schmitzer, Jan Kufer, Stephan Kaczmarz, Dennis M. Hedderich, Andreas Ranft, Daniel Golkowski, Josef Priller, Claus Zimmer, Rüdiger Ilg, Gerhard Schneider, Christine Preibisch, Christian Sorg, Benedikt Zott
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Summary:In the mammalian brain, the directed motion of cerebrospinal fluid (CSF-flux) is instrumental in the distribution and removal of solutes. Changes in total cerebral blood volume (CBV) have been hypothesized to drive CSF-flux. We tested this hypothesis in two multimodal brain imaging experiments in healthy humans, in which we drove large changes in total CBV by neuronal burst-suppression under anesthesia or by transient global vasodilation in a hypercapnic challenge. We indirectly monitored CBV changes with a high temporal resolution based on associated changes in total brain volume by functional MRI (fMRI) and measured cerebral blood flow by arterial spin-labeling. Relating CBV-sensitive signals to fMRI-derived measures of macroscopic CSF flow across the basal cisternae, we demonstrate that increasing total CBV extrudes CSF from the skull and decreasing CBV allows its influx. Moreover, CSF largely stagnates when CBV is stable. Together, our results establish the direct coupling between total CBV changes and CSF-flux.
Item Description:Gesehen am 03.12.2025
Physical Description:Online Resource
ISSN:1545-7885
DOI:10.1371/journal.pbio.3003138

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