Harnessing small RNAs as synthetic post-transcriptional regulators in bacteria
Bacteria can respond to environmental changes by expressing small RNAs (sRNAs), which regulate mRNAs by complementary base-pairing. This regulatory mechanism allows bacteria to rapidly adapt their proteome. In recent years, sRNAs have gained attention as blueprints for synthetic regulators allowing...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 8, 2025
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| In: |
ACS synthetic biology
Year: 2025, Jahrgang: 14, Heft: 7, Pages: 1-13 |
| ISSN: | 2161-5063 |
| DOI: | 10.1021/acssynbio.5c00118 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1021/acssynbio.5c00118 Verlag, kostenfrei, Volltext: https://pubs.acs.org/doi/10.1021/acssynbio.5c00118 
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| Verfasserangaben: | Jens Georg, Bork A. Berghoff and Daniel Schindler |
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| 520 | |a Bacteria can respond to environmental changes by expressing small RNAs (sRNAs), which regulate mRNAs by complementary base-pairing. This regulatory mechanism allows bacteria to rapidly adapt their proteome. In recent years, sRNAs have gained attention as blueprints for synthetic regulators allowing control over user-defined targets. Multiple aspects need to be considered for efficient application of these versatile, on-demand, and easy-to-use tools. Advances in computational prediction and bioengineering concepts are the dawn of systematic synthetic sRNA biology. We provide an overview of sRNAs and alternative | ||
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