Cannabinoids and the endocannabinoid system in reward processing and addiction: from mechanisms to interventions
The last decades have seen a major gain in understanding the action of cannabinoids and the endocannabinoid system in reward processing and the development of addictive behavior. Cannabis-derived psychoactive compounds such as Δ9-tetrahydrocannabinol and synthetic cannabinoids directly interact with...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2020
|
| In: |
Dialogues in clinical neuroscience
Year: 2020, Jahrgang: 22, Heft: 3, Pages: 241-250 |
| ISSN: | 1958-5969 |
| DOI: | 10.31887/DCNS.2020.22.3/rspanagel |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.31887/DCNS.2020.22.3/rspanagel Verlag, kostenfrei, Volltext: https://www.tandfonline.com/doi/full/10.31887/DCNS.2020.22.3/rspanagel 
|
| Verfasserangaben: | Rainer Spanagel |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1945038500 | ||
| 003 | DE-627 | ||
| 005 | 20251208134933.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251208s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.31887/DCNS.2020.22.3/rspanagel |2 doi | |
| 035 | |a (DE-627)1945038500 | ||
| 035 | |a (DE-599)KXP1945038500 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Spanagel, Rainer |d 1961- |e VerfasserIn |0 (DE-588)112706312 |0 (DE-627)521941261 |0 (DE-576)289740002 |4 aut | |
| 245 | 1 | 0 | |a Cannabinoids and the endocannabinoid system in reward processing and addiction |b from mechanisms to interventions |c Rainer Spanagel |
| 246 | 1 | |i Abweichender Titel der Frontdoor |a Los cannabinoides y el sistema endocannabinoide en el procesamiento de las recompensas y la adicción | |
| 246 | 1 | |i Abweichender Titel der Frontdoor |a Les cannabinoïdes et le système des endocannabinoïdes dans les processus de récompense et d’addiction | |
| 264 | 1 | |c 2020 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Elektronische Reproduktion der Druck-Ausgabe | ||
| 500 | |a Online publiziert: 1. April 2022 | ||
| 500 | |a Gesehen am 08.12.2025 | ||
| 520 | |a The last decades have seen a major gain in understanding the action of cannabinoids and the endocannabinoid system in reward processing and the development of addictive behavior. Cannabis-derived psychoactive compounds such as Δ9-tetrahydrocannabinol and synthetic cannabinoids directly interact with the reward system and thereby have addictive properties. Cannabinoids induce their reinforcing properties by an increase in tonic dopamine levels through a cannabinoid type 1 (CB1) receptor-dependent mechanism within the ventral tegmental area. Cues that are conditioned to cannabis smoking can induce drug-seeking responses (ie, craving) by eliciting phasic dopamine events. A dopamine-independent mechanism involved in drug-seeking responses involves an endocannabinoid/glutamate interaction within the corticostriatal part of the reward system. In conclusion, pharmacological blockade of endocannabinoid signaling should lead to a reduction in drug craving and subsequently should reduce relapse behavior in addicted individuals. Indeed, there is increasing preclinical evidence that targeting the endocannabinoid system reduces craving and relapse, and allosteric modulators at CB1 receptors and fatty acid amide hydrolase inhibitors are in clinical development for cannabis use disorder. Cannabidiol, which mainly acts on CB1 and CB2 receptors, is currently being tested in patients with alcohol use disorder and opioid use disorder. | ||
| 650 | 4 | |a addiction | |
| 650 | 4 | |a alcohol | |
| 650 | 4 | |a cannabinoid | |
| 650 | 4 | |a CB1/CB2-receptor blockade | |
| 650 | 4 | |a cocaine | |
| 650 | 4 | |a craving | |
| 650 | 4 | |a drug reward | |
| 650 | 4 | |a endocannabinoid system | |
| 650 | 4 | |a heroin | |
| 650 | 4 | |a natural reward | |
| 650 | 4 | |a nicotine | |
| 650 | 4 | |a phasic dopamine | |
| 650 | 4 | |a reward system | |
| 650 | 4 | |a substitution therapy | |
| 650 | 4 | |a tonic dopamine | |
| 773 | 0 | 8 | |i Enthalten in |t Dialogues in clinical neuroscience |d London : Taylor & Francis Group, 1999 |g 22(2020), 3, Seite 241-250 |h Online-Ressource |w (DE-627)518100987 |w (DE-600)2251450-8 |w (DE-576)281320071 |x 1958-5969 |7 nnas |a Cannabinoids and the endocannabinoid system in reward processing and addiction from mechanisms to interventions |
| 773 | 1 | 8 | |g volume:22 |g year:2020 |g number:3 |g pages:241-250 |g extent:10 |a Cannabinoids and the endocannabinoid system in reward processing and addiction from mechanisms to interventions |
| 856 | 4 | 0 | |u https://doi.org/10.31887/DCNS.2020.22.3/rspanagel |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.tandfonline.com/doi/full/10.31887/DCNS.2020.22.3/rspanagel |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20251208 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 112706312 |a Spanagel, Rainer |m 112706312:Spanagel, Rainer |d 140000 |d 60000 |e 140000PS112706312 |e 60000PS112706312 |k 0/140000/ |k 0/60000/ |p 1 |x j |y j | ||
| 999 | |a KXP-PPN1945038500 |e 4824415977 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Rainer Spanagel"]},"person":[{"role":"aut","given":"Rainer","display":"Spanagel, Rainer","family":"Spanagel"}],"titleAlt":[{"title":"Los cannabinoides y el sistema endocannabinoide en el procesamiento de las recompensas y la adicción"},{"title":"Les cannabinoïdes et le système des endocannabinoïdes dans les processus de récompense et d’addiction"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"2020","dateIssuedKey":"2020"}],"recId":"1945038500","physDesc":[{"extent":"10 S."}],"id":{"doi":["10.31887/DCNS.2020.22.3/rspanagel"],"eki":["1945038500"]},"note":["Elektronische Reproduktion der Druck-Ausgabe","Online publiziert: 1. April 2022","Gesehen am 08.12.2025"],"relHost":[{"pubHistory":["Vol. 1 (1999)-"],"title":[{"title_sort":"Dialogues in clinical neuroscience","title":"Dialogues in clinical neuroscience"}],"part":{"text":"22(2020), 3, Seite 241-250","year":"2020","volume":"22","extent":"10","pages":"241-250","issue":"3"},"language":["eng"],"id":{"eki":["518100987"],"zdb":["2251450-8"],"issn":["1958-5969"]},"disp":"Cannabinoids and the endocannabinoid system in reward processing and addiction from mechanisms to interventionsDialogues in clinical neuroscience","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 09.07.24"],"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"1999","dateIssuedDisp":"1999-","publisher":"Taylor & Francis Group ; Les Laboratoires Servier","publisherPlace":"London ; Neuilly-sur-Seine"}],"recId":"518100987"}],"title":[{"title_sort":"Cannabinoids and the endocannabinoid system in reward processing and addiction","subtitle":"from mechanisms to interventions","title":"Cannabinoids and the endocannabinoid system in reward processing and addiction"}],"language":["eng"]} | ||
| SRT | |a SPANAGELRACANNABINOI2020 | ||