Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala

BackgroundBasic neuroscience has identified dopamine and corticotropin-releasing hormone (CRH) systems and amygdala circuits as key contributors to drug and alcohol reward, craving, and relapse. However, directly targeting these systems has had no impact on the treatment of addictive disorders. CRH...

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Main Authors:	Broccoli, Laura (Author) , Bernardi, Rick E. (Author) , Giannone, Francesco (Author) , Hoppe, Anika (Author) , Jungling, Kay (Author) , Borroto-Escuela, Dasiel O. (Author) , Rimondini-Giorgini, Roberto (Author) , Pérez de la Mora, Miguel (Author) , von Bohlen und Halbach, Oliver (Author) , Fuxe, Kjell (Author) , Pape, Hans-Christian (Author) , Deussing, Jan M. (Author) , Spanagel, Rainer (Author) , Sommer, Wolfgang H. (Author) , Hansson, Anita C. (Author)
Format:	Article (Journal)
Language:	English
Published:	16 October 2025
In:	Frontiers in pharmacology Year: 2025, Volume: 16, Pages: 1-20
ISSN:	1663-9812
DOI:	10.3389/fphar.2025.1677510
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fphar.2025.1677510 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1677510/full
Author Notes:	Laura Broccoli, Rick E. Bernardi, Francesco Giannone, Anika Hoppe, Kay Jungling, Dasiel O. Borroto-Escuela, Roberto Rimondini-Giorgini, Miguel Pérez de la Mora, Oliver von Bohlen und Halbach, Kjell Fuxe, Hans-Christian Pape, Jan M. Deussing, Rainer Spanagel, Wolfgang H. Sommer and Anita C. Hansson