Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala
BackgroundBasic neuroscience has identified dopamine and corticotropin-releasing hormone (CRH) systems and amygdala circuits as key contributors to drug and alcohol reward, craving, and relapse. However, directly targeting these systems has had no impact on the treatment of addictive disorders. CRH...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 October 2025
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| In: |
Frontiers in pharmacology
Year: 2025, Jahrgang: 16, Pages: 1-20 |
| ISSN: | 1663-9812 |
| DOI: | 10.3389/fphar.2025.1677510 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fphar.2025.1677510 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1677510/full |
| Verfasserangaben: | Laura Broccoli, Rick E. Bernardi, Francesco Giannone, Anika Hoppe, Kay Jungling, Dasiel O. Borroto-Escuela, Roberto Rimondini-Giorgini, Miguel Pérez de la Mora, Oliver von Bohlen und Halbach, Kjell Fuxe, Hans-Christian Pape, Jan M. Deussing, Rainer Spanagel, Wolfgang H. Sommer and Anita C. Hansson |
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