A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling
Impaired cardiac function in heart failure (HF) involves tissue remodeling through multicellular coordination. Although individual bulk and single-nucleus transcriptomics studies have offered insights, they have not been integrated to study conserved tissue-wide responses, limiting understanding of...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
31 October 2025
|
| In: |
Nature Communications
Year: 2025, Volume: 16, Pages: 1-21 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-025-62219-6 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-62219-6 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-62219-6 
|
| Author Notes: | Jan D. Lanzer, Ricardo O. Ramirez Flores, José Liñares Blanco, Marco Steier, Ashraf Y. Rangrez, Norbert Frey, Julio Saez-Rodriguez |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1945731338 | ||
| 003 | DE-627 | ||
| 005 | 20260113171605.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251210s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-025-62219-6 |2 doi | |
| 035 | |a (DE-627)1945731338 | ||
| 035 | |a (DE-599)KXP1945731338 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lanzer, Jan David |d 1991- |e VerfasserIn |0 (DE-588)1178380025 |0 (DE-627)1049324005 |0 (DE-576)517758016 |4 aut | |
| 245 | 1 | 2 | |a A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling |c Jan D. Lanzer, Ricardo O. Ramirez Flores, José Liñares Blanco, Marco Steier, Ashraf Y. Rangrez, Norbert Frey, Julio Saez-Rodriguez |
| 264 | 1 | |c 31 October 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 21 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.12.2025 | ||
| 520 | |a Impaired cardiac function in heart failure (HF) involves tissue remodeling through multicellular coordination. Although individual bulk and single-nucleus transcriptomics studies have offered insights, they have not been integrated to study conserved tissue-wide responses, limiting understanding of multicellular processes in cardiac remodeling necessary for therapeutic translation. Here, we integrate 25 studies of bulk and single-nucleus transcriptomics, spanning 1524 individuals, to define consensus multicellular programs associated with HF. These programs reveal conserved fibrotic, inflammatory, metabolic, and hypertrophic processes, with fibroblast activity consistently predicting cardiomyocyte stress. Our integration revealed that multicellular programs in HF are largely independent of tissue composition, and that fibroblast activation reflects a broad phenotypic shift rather than solely the emergence of discrete subtypes. Projecting external datasets onto these programs showed that clinical recovery aligns with reversion of disease-associated programs. This integrative analysis across studies establishes a public reference for the exploration of multicellular coordination in HF. | ||
| 650 | 4 | |a Computational biology and bioinformatics | |
| 650 | 4 | |a Data integration | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a Multicellular systems | |
| 700 | 1 | |a Ramirez Flores, Ricardo O. |e VerfasserIn |0 (DE-588)1233991973 |0 (DE-627)1758398167 |4 aut | |
| 700 | 1 | |a Liñares Blanco, José |e VerfasserIn |4 aut | |
| 700 | 1 | |a Steier, Marco |d 1992- |e VerfasserIn |0 (DE-588)1383935629 |0 (DE-627)1945732946 |4 aut | |
| 700 | 1 | |a Rangrez, Ashraf Yusuf |e VerfasserIn |0 (DE-588)1222601885 |0 (DE-627)1741689279 |4 aut | |
| 700 | 1 | |a Frey, Norbert |e VerfasserIn |0 (DE-588)141244976 |0 (DE-627)625824075 |0 (DE-576)322969514 |4 aut | |
| 700 | 1 | |a Sáez Rodríguez, Julio |d 1978- |e VerfasserIn |0 (DE-588)133764362 |0 (DE-627)555766632 |0 (DE-576)300083114 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 16(2025), Artikel-ID 9659, Seite 1-21 |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling |
| 773 | 1 | 8 | |g volume:16 |g year:2025 |g elocationid:9659 |g pages:1-21 |g extent:21 |a A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41467-025-62219-6 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41467-025-62219-6 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20251210 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 133764362 |a Sáez Rodríguez, Julio |m 133764362:Sáez Rodríguez, Julio |d 910000 |d 912900 |e 910000PS133764362 |e 912900PS133764362 |k 0/910000/ |k 1/910000/912900/ |p 7 |y j | ||
| 998 | |g 141244976 |a Frey, Norbert |m 141244976:Frey, Norbert |d 910000 |d 910100 |e 910000PF141244976 |e 910100PF141244976 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 1222601885 |a Rangrez, Ashraf Yusuf |m 1222601885:Rangrez, Ashraf Yusuf |d 910000 |d 910100 |e 910000PR1222601885 |e 910100PR1222601885 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 1383935629 |a Steier, Marco |m 1383935629:Steier, Marco |d 910000 |d 910100 |d 140000 |e 910000PS1383935629 |e 910100PS1383935629 |e 140000PS1383935629 |k 0/910000/ |k 1/910000/910100/ |k 0/140000/ |p 4 | ||
| 998 | |g 1233991973 |a Ramirez Flores, Ricardo O. |m 1233991973:Ramirez Flores, Ricardo O. |p 2 | ||
| 998 | |g 1178380025 |a Lanzer, Jan David |m 1178380025:Lanzer, Jan David |d 700000 |d 716000 |e 700000PL1178380025 |e 716000PL1178380025 |k 0/700000/ |k 1/700000/716000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1945731338 |e 4826068417 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Lanzer","display":"Lanzer, Jan David","given":"Jan David","role":"aut"},{"family":"Ramirez Flores","display":"Ramirez Flores, Ricardo O.","role":"aut","given":"Ricardo O."},{"role":"aut","given":"José","display":"Liñares Blanco, José","family":"Liñares Blanco"},{"given":"Marco","role":"aut","display":"Steier, Marco","family":"Steier"},{"given":"Ashraf Yusuf","role":"aut","display":"Rangrez, Ashraf Yusuf","family":"Rangrez"},{"family":"Frey","display":"Frey, Norbert","given":"Norbert","role":"aut"},{"role":"aut","given":"Julio","family":"Sáez Rodríguez","display":"Sáez Rodríguez, Julio"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling","title":"A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling"}],"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"31 October 2025"}],"note":["Gesehen am 10.12.2025"],"id":{"eki":["1945731338"],"doi":["10.1038/s41467-025-62219-6"]},"relHost":[{"title":[{"title_sort":"Nature Communications","title":"Nature Communications"}],"note":["Gesehen am 13.06.24"],"origin":[{"publisherPlace":"[London] ; [London]","dateIssuedDisp":"[2010]-","publisher":"Springer Nature ; Nature Publishing Group UK"}],"pubHistory":["2010-"],"disp":"A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodelingNature Communications","type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"626457688","id":{"zdb":["2553671-0"],"issn":["2041-1723"],"eki":["626457688"]},"language":["eng"],"part":{"year":"2025","pages":"1-21","extent":"21","text":"16(2025), Artikel-ID 9659, Seite 1-21","volume":"16"}}],"recId":"1945731338","physDesc":[{"extent":"21 S.","noteIll":"Illustrationen"}],"name":{"displayForm":["Jan D. Lanzer, Ricardo O. Ramirez Flores, José Liñares Blanco, Marco Steier, Ashraf Y. Rangrez, Norbert Frey, Julio Saez-Rodriguez"]}} | ||
| SRT | |a LANZERJANDCROSSSTUDY3120 | ||