Prognostic impact of lepidic growth in intermediate and high-grade lung adenocarcinoma
Background - Grade 1 lung adenocarcinomas, which are characterized by predominantly lepidic growth and less than 20 % high-risk patterns, have a favorable survival rate compared to higher-grade tumors. However, the prognostic relevance of lepidic components in intermediate and high-grade tumors (gra...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 2025
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| In: |
Lung cancer
Year: 2025, Jahrgang: 206, Pages: 1-7 |
| ISSN: | 1872-8332 |
| DOI: | 10.1016/j.lungcan.2025.108674 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.lungcan.2025.108674 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0169500225005665 
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| Verfasserangaben: | Benedikt Niedermaier, Erik Rolf, Michael Allgäuer, Laura V. Klotz, Marc A. Schneider, Kadriya Yuskaeva, Martin E. Eichhorn, Hauke Winter |
| Zusammenfassung: | Background - Grade 1 lung adenocarcinomas, which are characterized by predominantly lepidic growth and less than 20 % high-risk patterns, have a favorable survival rate compared to higher-grade tumors. However, the prognostic relevance of lepidic components in intermediate and high-grade tumors (grades 2-3) remains unclear. We investigated whether lepidic growth impacts survival in grade 2-3 stage I lung adenocarcinomas. - Methods - 479 consecutive patients who underwent curative resection for non-mucinous lung adenocarcinoma in pathologic grade 2-3 and stage I were enrolled in this retrospective, single-center study. The impact of lepidic components and other predictors on survival was assessed in multivariable cox regression. - Results - Lepidic growth was present in 300 (62.6 %) tumors. Patients with lepidic-positive tumors were significantly older (median age 67 vs. 65 years, p = 0.015), more frequently never-smokers (22.1 % vs. 9.9 %, p = 0.001), had higher proportions of acinar-predominant (69.0 % vs. 53.1 %, p = 0.001), and fewer solid-predominant tumors (7.0 % vs. 26.8 %, p < 0.001). Median follow-up was 67 months (IQR 47-92). Multivariable Cox analysis demonstrated no significant association between lepidic growth and overall or recurrence-free survival. Factors significantly affecting recurrence-free survival included age ≥ 70 years (HR 1.40, p = 0.046), stage IB (HR 1.52, p = 0.017), grade 3 tumors (HR 1.42, p = 0.040), and lymphatic invasion (HR 1.67, p = 0.011). - Conclusion - Lepidic growth did not demonstrate prognostic significance in intermediate and high-grade non-mucinous lung adenocarcinoma in this study. |
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| Beschreibung: | Gesehen am 10.12.2025 |
| Beschreibung: | Online Resource |
| ISSN: | 1872-8332 |
| DOI: | 10.1016/j.lungcan.2025.108674 |