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Image-based meta- and mega-analysis (IBMMA): a unified framework for large-scale, multi-site, neuroimaging data analysis

The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited computational speed and inefficient memory allocation, and are...

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Main Authors: Steele, Nick (Author) , Huggins, Ashley A. (Author) , Morey, Rajendra A. (Author) , Hussain, Ahmed (Author) , Russell, Courtney (Author) , Suarez-Jimenez, Benjamin (Author) , Pozzi, Elena (Author) , Jameei, Hadis (Author) , Schmaal, Lianne (Author) , Veer, Ilya M. (Author) , Waller, Lea (Author) , Jahanshad, Neda (Author) , Thomopoulos, Sophia I. (Author) , Salminen, Lauren E. (Author) , Olff, Miranda (Author) , Frijling, Jessie L. (Author) , Veltman, Dick J. (Author) , Koch, Saskia B. J. (Author) , Nawijn, Laura (Author) , van Zuiden, Mirjam (Author) , Wang, Li (Author) , Zhu, Ye (Author) , Li, Gen (Author) , Stein, Dan J. (Author) , Ipser, Jonathan (Author) , Neria, Yuval (Author) , Zhu, Xi (Author) , Ravid, Orren (Author) , Zilcha-Mano, Sigal (Author) , Lazarov, Amit (Author) , Stevens, Jennifer S. (Author) , Ressler, Kerry (Author) , Jovanovic, Tanja (Author) , van Rooij, Sanne J. H. (Author) , Fani, Negar (Author) , Mueller, Sven C. (Author) , Hudson, Anna R. (Author) , Daniels, Judith K. (Author) , Sierk, Anika (Author) , Manthey, Antje (Author) , Walter, Henrik (Author) , van der Wee, Nic J. A. (Author) , van der Werff, Steven J. A. (Author) , Vermeiren, Robert R. J. M. (Author) , Schmahl, Christian (Author) , Herzog, Julia (Author) , Rektor, Ivan (Author) , Říha, Pavel (Author) , Kaufman, Milissa L. (Author) , Lebois, Lauren A. M. (Author) , Baker, Justin T. (Author) , Rosso, Isabelle M. (Author) , Olson, Elizabeth A. (Author) , King, Anthony (Author) , Liberzon, Israel (Author) , Angstadt, Michael (Author) , Davenport, Nicholas D. (Author) , Disner, Seth G. (Author) , Sponheim, Scott R. (Author) , Straube, Thomas (Author) , Hofmann, David (Author) , Lu, Guangming (Author) , Qi, Rongfeng (Author) , Wang, Xin (Author) , Kunch, Austin (Author) , Xie, Hong (Author) , Quidé, Yann (Author) , El-Hage, Wissam (Author) , Lissek, Shmuel (Author) , Berg, Hannah (Author) , Bruce, Steven E. (Author) , Cisler, Josh (Author) , Ross, Marisa (Author) , Herringa, Ryan J. (Author) , Grupe, Daniel W. (Author) , Nitschke, Jack B. (Author) , Davidson, Richard J. (Author) , Larson, Christine (Author) , deRoon-Cassini, Terri A. (Author) , Tomas, Carissa W. (Author) , Fitzgerald, Jacklynn M. (Author) , Elman, Jeremy (Author) , Panizzon, Matthew (Author) , Franz, Carol E. (Author) , Lyons, Michael J. (Author) , Kremen, William S. (Author) , Feola, Brandee (Author) , Blackford, Jennifer U. (Author) , Olatunji, Bunmi O. (Author) , May, Geoffrey (Author) , Nelson, Steven M. (Author) , Gordon, Evan M. (Author) , Abdallah, Chadi G. (Author) , Lanius, Ruth (Author) , Densmore, Maria (Author) , Théberge, Jean (Author) , Neufeld, Richard W. J. (Author) , Thompson, Paul M. (Author) , Sun, Delin (Author)
Format: Article (Journal)
Language:English
Published: 15 November 2025
In: NeuroImage
Year: 2025, Volume: 322, Pages: 1-12
ISSN:1095-9572
DOI:10.1016/j.neuroimage.2025.121554
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.neuroimage.2025.121554
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1053811925005579
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Author Notes:Nick Steele, Ashley A. Huggins, Rajendra A. Morey, Ahmed Hussain, Courtney Russell, Benjamin Suarez-Jimenez, Elena Pozzi, Hadis Jameei, Lianne Schmaal, Ilya M. Veer, Lea Waller, Neda Jahanshad, Sophia I. Thomopoulos, Lauren E. Salminen, Miranda Olff, Jessie L. Frijling, Dick J. Veltman, Saskia B.J. Koch, Laura Nawijn, Mirjam van Zuiden, Li Wang, Ye Zhu, Gen Li, Dan J. Stein, Jonathan Ipser, Yuval Neria, Xi Zhu, Orren Ravid, Sigal Zilcha-Mano, Amit Lazarov, Jennifer S. Stevens, Kerry Ressler, Tanja Jovanovic, Sanne J.H. van Rooij, Negar Fani, Sven C. Mueller, Anna R. Hudson, Judith K. Daniels, Anika Sierk, Antje Manthey, Henrik Walter, Nic J.A. van der Wee, Steven J.A. van der Werff, Robert R.J.M. Vermeiren, Christian Schmahl, Julia I. Herzog, Ivan Rektor, Pavel Říha, Milissa L. Kaufman, Lauren A.M. Lebois, Justin T. Baker, Isabelle M. Rosso, Elizabeth A. Olson, Anthony King, Israel Liberzon, Michael Angstadt, Nicholas D. Davenport, Seth G. Disner, Scott R. Sponheim, Thomas Straube, David Hofmann, Guangming Lu, Rongfeng Qi, Xin Wang, Austin Kunch, Hong Xie, Yann Quidé, Wissam El-Hage, Shmuel Lissek, Hannah Berg, Steven E. Bruce, Josh Cisler, Marisa Ross, Ryan J. Herringa, Daniel W. Grupe, Jack B. Nitschke, Richard J. Davidson, Christine Larson, Terri A. deRoon-Cassini, Carissa W. Tomas, Jacklynn M. Fitzgerald, Jeremy Elman, Matthew Panizzon, Carol E. Franz, Michael J. Lyons, William S. Kremen, Brandee Feola, Jennifer U. Blackford, Bunmi O. Olatunji, Geoffrey May, Steven M. Nelson, Evan M. Gordon, Chadi G. Abdallah, Ruth Lanius, Maria Densmore, Jean Théberge, Richard W.J. Neufeld, Paul M. Thompson, Delin Sun

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