Massively parallel microbubble nano-assembly
Microbubbles are an important tool due to their unique mechanical, acoustic, and dynamical properties. Yet, it remains challenging to generate microbubbles quickly in a parallel, biocompatible, and controlled manner. Here, we present an opto-electrochemical method that combines precise light-based p...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 July 2025
|
| In: |
Nature Communications
Year: 2025, Volume: 16, Pages: 1-11 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-025-62070-9 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-62070-9 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-62070-9 
|
| Author Notes: | Hyungmok Joh, Bin Lian, Shaw-iong Hsueh, Zhichao Ma, Keng-Jung Lee, Si-Yang Zheng, Peer Fischer & Donglei Emma Fan |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1945904658 | ||
| 003 | DE-627 | ||
| 005 | 20260113171557.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251211s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-025-62070-9 |2 doi | |
| 035 | |a (DE-627)1945904658 | ||
| 035 | |a (DE-599)KXP1945904658 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Joh, Hyungmok |e VerfasserIn |0 (DE-588)1384085130 |0 (DE-627)1945905247 |4 aut | |
| 245 | 1 | 0 | |a Massively parallel microbubble nano-assembly |c Hyungmok Joh, Bin Lian, Shaw-iong Hsueh, Zhichao Ma, Keng-Jung Lee, Si-Yang Zheng, Peer Fischer & Donglei Emma Fan |
| 264 | 1 | |c 22 July 2025 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.12.2025 | ||
| 520 | |a Microbubbles are an important tool due to their unique mechanical, acoustic, and dynamical properties. Yet, it remains challenging to generate microbubbles quickly in a parallel, biocompatible, and controlled manner. Here, we present an opto-electrochemical method that combines precise light-based projection with low-energy electrolysis, realizing defined microbubble patterns that in turn trigger assembly processes. The size of the bubbles can be controlled from a few to over hundred micrometers with a spatial accuracy of ~2 μm. The minimum required light intensity is only ~0.1 W/cm2, several orders of magnitude lower compared to other light-enabled methods. We demonstrate the assembly of prescribed patterns of 40-nm nanocrystals, 200 nm extracellular vesicles, polymer nanospheres, and live bacteria. We show how nanosensor-bacterial-cell arrays can be formed for spectroscopic profiling of metabolites and antibiotic response of bacterial assemblies. The combination of a photoconductor with electrochemical techniques enables low-energy, low-temperature bubble generation, advantageous for large-scale, one-shot patterning of diverse particles in a biocompatible manner. The microbubble-platform is highly versatile and promises new opportunities in nanorobotics, nanomanufacturing, high-throughput bioassays, single cell omics, bioseparation, and drug screening and discovery. | ||
| 650 | 4 | |a Biosensors | |
| 650 | 4 | |a Nanofabrication and nanopatterning | |
| 650 | 4 | |a Surface patterning | |
| 700 | 1 | |a Lian, Bin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hsueh, Shaw-iong |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ma, Zhichao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lee, Keng-Jung |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zheng, Si-Yang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fischer, Peer |d 1972- |e VerfasserIn |0 (DE-588)1037836367 |0 (DE-627)756337402 |0 (DE-576)391876503 |4 aut | |
| 700 | 1 | |a Fan, Donglei Emma |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 16(2025), Artikel-ID 6743, Seite 1-11 |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a Massively parallel microbubble nano-assembly |
| 773 | 1 | 8 | |g volume:16 |g year:2025 |g elocationid:6743 |g pages:1-11 |g extent:11 |a Massively parallel microbubble nano-assembly |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41467-025-62070-9 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41467-025-62070-9 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20251211 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1037836367 |a Fischer, Peer |m 1037836367:Fischer, Peer |d 160000 |d 160200 |e 160000PF1037836367 |e 160200PF1037836367 |k 0/160000/ |k 1/160000/160200/ |p 7 | ||
| 999 | |a KXP-PPN1945904658 |e 4826558481 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"person":[{"role":"aut","display":"Joh, Hyungmok","given":"Hyungmok","family":"Joh"},{"display":"Lian, Bin","role":"aut","family":"Lian","given":"Bin"},{"role":"aut","display":"Hsueh, Shaw-iong","given":"Shaw-iong","family":"Hsueh"},{"display":"Ma, Zhichao","role":"aut","family":"Ma","given":"Zhichao"},{"given":"Keng-Jung","family":"Lee","role":"aut","display":"Lee, Keng-Jung"},{"family":"Zheng","given":"Si-Yang","display":"Zheng, Si-Yang","role":"aut"},{"given":"Peer","family":"Fischer","role":"aut","display":"Fischer, Peer"},{"display":"Fan, Donglei Emma","role":"aut","family":"Fan","given":"Donglei Emma"}],"relHost":[{"id":{"zdb":["2553671-0"],"issn":["2041-1723"],"eki":["626457688"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"volume":"16","extent":"11","year":"2025","pages":"1-11","text":"16(2025), Artikel-ID 6743, Seite 1-11"},"pubHistory":["2010-"],"origin":[{"dateIssuedDisp":"[2010]-","publisher":"Springer Nature ; Nature Publishing Group UK","publisherPlace":"[London] ; [London]"}],"recId":"626457688","physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Nature Communications","title":"Nature Communications"}],"language":["eng"],"disp":"Massively parallel microbubble nano-assemblyNature Communications","note":["Gesehen am 13.06.24"]}],"title":[{"title":"Massively parallel microbubble nano-assembly","title_sort":"Massively parallel microbubble nano-assembly"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1945904658"],"doi":["10.1038/s41467-025-62070-9"]},"physDesc":[{"extent":"11 S."}],"note":["Gesehen am 11.12.2025"],"name":{"displayForm":["Hyungmok Joh, Bin Lian, Shaw-iong Hsueh, Zhichao Ma, Keng-Jung Lee, Si-Yang Zheng, Peer Fischer & Donglei Emma Fan"]},"recId":"1945904658","origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"22 July 2025"}]} | ||
| SRT | |a JOHHYUNGMOMASSIVELYP2220 | ||