Strengthening antimicrobial resistance diagnostics in National Reference Laboratories across One Health in South and Southeast Asia: impact of external quality assessment and targeted follow-up
The intent of this study was to evaluate and improve microbiology laboratory diagnostic capacity in selected National AMR Reference laboratories from South and Southeast Asia for AMR testing utilizing EQA and targeted follow-up support.A baseline assessment was conducted to evaluate quality manageme...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2025
|
| In: |
The journal of antimicrobial chemotherapy
Year: 2025, Jahrgang: 80, Heft: 9, Pages: 2541-2549 |
| ISSN: | 1460-2091 |
| DOI: | 10.1093/jac/dkaf266 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1093/jac/dkaf266 Verlag, kostenfrei, Volltext: https://academic.oup.com/jac/article/80/9/2541/8217017 
|
| Verfasserangaben: | Freshwork Ayalew Abegaz, Hiba Al-mir, Tomislav Kostyanev, Kristi Prifti, Soo-Young Kwon, Tobin Guarnacci, Lone Brink Rasmussen, Mohammad Julhas Sujan, Patrícia Teixeira Dos Santos, Rangsiya Prathan, Taradon Luangtongkum, Pattrarat Chanchaitong, Pitak Santanirand, Watcharaporn Kamjumpho, Ondari D Mogeni, Marianne Holm, Florian Marks, Rungtip Chuanchuen, Rene S Hendriksen and Nimesh Poudyal |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1945905956 | ||
| 003 | DE-627 | ||
| 005 | 20251211133536.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251211s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/jac/dkaf266 |2 doi | |
| 035 | |a (DE-627)1945905956 | ||
| 035 | |a (DE-599)KXP1945905956 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Abegaz, Freshwork |e VerfasserIn |0 (DE-588)1328440613 |0 (DE-627)1887893105 |4 aut | |
| 245 | 1 | 0 | |a Strengthening antimicrobial resistance diagnostics in National Reference Laboratories across One Health in South and Southeast Asia |b impact of external quality assessment and targeted follow-up |c Freshwork Ayalew Abegaz, Hiba Al-mir, Tomislav Kostyanev, Kristi Prifti, Soo-Young Kwon, Tobin Guarnacci, Lone Brink Rasmussen, Mohammad Julhas Sujan, Patrícia Teixeira Dos Santos, Rangsiya Prathan, Taradon Luangtongkum, Pattrarat Chanchaitong, Pitak Santanirand, Watcharaporn Kamjumpho, Ondari D Mogeni, Marianne Holm, Florian Marks, Rungtip Chuanchuen, Rene S Hendriksen and Nimesh Poudyal |
| 264 | 1 | |c September 2025 | |
| 300 | |b Diagramme | ||
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 29. Juli 2025 | ||
| 500 | |a Gesehen am 11.12.2025 | ||
| 520 | |a The intent of this study was to evaluate and improve microbiology laboratory diagnostic capacity in selected National AMR Reference laboratories from South and Southeast Asia for AMR testing utilizing EQA and targeted follow-up support.A baseline assessment was conducted to evaluate quality management system (QMS) practices for laboratories participating in the Strengthening External Quality Assessment in Asia (EQASIA-EQA) programme for the first time. Following each EQA iteration, laboratory assessments were conducted, and underperforming laboratories received online consultations to identify root causes of deviations and implement corrective and preventive actions (CAPA). Laboratories with persistent underperformance, onsite visits and targeted training sessions were provided to support quality improvement.Significant gaps were identified in the QMS of the 24 laboratories surveyed, with 38% lacking a QMS and 42% not conducting internal audits. Many laboratories lacked standard operating procedures (SOPs) for key processes, CAPA and equipment maintenance. Training and competency assessments were insufficient, with 50% of laboratories not conducting competency assessments. Additionally, 46% did not perform root cause analysis for EQA deviations, and 42% lacked a structured quality control programme. Water purity testing and equipment maintenance were also inadequate. Of the four baseline-assessed laboratories, three underperformed twice, and one underperformed three times across EQA iterations. Key deficiencies included the absence of a QMS and SOPs, as well as inadequate staff training and internal quality control. After targeted follow-up support, improvements were observed in QMS implementation, SOP development, staff training and quality control.Participation in EQA, combined with targeted follow-up support, enhances laboratory quality and performance. These improvements ultimately contribute to the provision of reliable data that can guide policy actions to combat AMR. | ||
| 700 | 1 | |a Al-mir, Hiba |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kostyanev, Tomislav |e VerfasserIn |4 aut | |
| 700 | 1 | |a Prifti, Kristi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kwon, Soo-Young |e VerfasserIn |4 aut | |
| 700 | 1 | |a Guarnacci, Tobin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rasmussen, Lone Brink |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sujan, Mohammad Julhas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Teixeira Dos Santos, Patrícia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Prathan, Rangsiya |e VerfasserIn |4 aut | |
| 700 | 1 | |a Luangtongkum, Taradon |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chanchaitong, Pattrarat |e VerfasserIn |4 aut | |
| 700 | 1 | |a Santanirand, Pitak |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kamjumpho, Watcharaporn |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mogeni, Ondari D |e VerfasserIn |4 aut | |
| 700 | 1 | |a Holm, Marianne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Marks, Florian |d 1975- |e VerfasserIn |0 (DE-588)130584258 |0 (DE-627)504163736 |0 (DE-576)298281589 |4 aut | |
| 700 | 1 | |a Chuanchuen, Rungtip |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hendriksen, Rene S |e VerfasserIn |4 aut | |
| 700 | 1 | |a Poudyal, Nimesh |e VerfasserIn |0 (DE-588)1328439488 |0 (DE-627)1887891811 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of antimicrobial chemotherapy |d Oxford : Oxford Univ. Press, 1975 |g 80(2025), 9, Seite 2541-2549 |h Online-Ressource |w (DE-627)266876838 |w (DE-600)1467478-6 |w (DE-576)075144972 |x 1460-2091 |7 nnas |a Strengthening antimicrobial resistance diagnostics in National Reference Laboratories across One Health in South and Southeast Asia impact of external quality assessment and targeted follow-up |
| 773 | 1 | 8 | |g volume:80 |g year:2025 |g number:9 |g pages:2541-2549 |g extent:9 |a Strengthening antimicrobial resistance diagnostics in National Reference Laboratories across One Health in South and Southeast Asia impact of external quality assessment and targeted follow-up |
| 856 | 4 | 0 | |u https://doi.org/10.1093/jac/dkaf266 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://academic.oup.com/jac/article/80/9/2541/8217017 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20251211 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 130584258 |a Marks, Florian |m 130584258:Marks, Florian |d 910000 |d 912800 |e 910000PM130584258 |e 912800PM130584258 |k 0/910000/ |k 1/910000/912800/ |p 17 | ||
| 999 | |a KXP-PPN1945905956 |e 4826562101 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":" September 2025","dateIssuedKey":"2025"}],"language":["eng"],"note":["Online verfügbar: 29. Juli 2025","Gesehen am 11.12.2025"],"recId":"1945905956","name":{"displayForm":["Freshwork Ayalew Abegaz, Hiba Al-mir, Tomislav Kostyanev, Kristi Prifti, Soo-Young Kwon, Tobin Guarnacci, Lone Brink Rasmussen, Mohammad Julhas Sujan, Patrícia Teixeira Dos Santos, Rangsiya Prathan, Taradon Luangtongkum, Pattrarat Chanchaitong, Pitak Santanirand, Watcharaporn Kamjumpho, Ondari D Mogeni, Marianne Holm, Florian Marks, Rungtip Chuanchuen, Rene S Hendriksen and Nimesh Poudyal"]},"relHost":[{"part":{"pages":"2541-2549","issue":"9","extent":"9","text":"80(2025), 9, Seite 2541-2549","year":"2025","volume":"80"},"disp":"Strengthening antimicrobial resistance diagnostics in National Reference Laboratories across One Health in South and Southeast Asia impact of external quality assessment and targeted follow-upThe journal of antimicrobial chemotherapy","titleAlt":[{"title":"JAC"}],"id":{"zdb":["1467478-6"],"eki":["266876838"],"issn":["1460-2091"]},"title":[{"subtitle":"JAC","title":"The journal of antimicrobial chemotherapy","title_sort":"journal of antimicrobial chemotherapy"}],"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"recId":"266876838","note":["Gesehen am 27.10.21"],"origin":[{"publisherPlace":"Oxford","publisher":"Oxford Univ. Press","dateIssuedDisp":"1975-","dateIssuedKey":"1975"}],"pubHistory":["1.1975 -"],"name":{"displayForm":["the British Society for Antimicrobial Chemotherapy"]}}],"title":[{"subtitle":"impact of external quality assessment and targeted follow-up","title_sort":"Strengthening antimicrobial resistance diagnostics in National Reference Laboratories across One Health in South and Southeast Asia","title":"Strengthening antimicrobial resistance diagnostics in National Reference Laboratories across One Health in South and Southeast Asia"}],"physDesc":[{"extent":"9 S.","noteIll":"Diagramme"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1093/jac/dkaf266"],"eki":["1945905956"]},"person":[{"given":"Freshwork","role":"aut","display":"Abegaz, Freshwork","family":"Abegaz"},{"family":"Al-mir","display":"Al-mir, Hiba","role":"aut","given":"Hiba"},{"given":"Tomislav","role":"aut","display":"Kostyanev, Tomislav","family":"Kostyanev"},{"role":"aut","given":"Kristi","family":"Prifti","display":"Prifti, Kristi"},{"given":"Soo-Young","role":"aut","display":"Kwon, Soo-Young","family":"Kwon"},{"family":"Guarnacci","display":"Guarnacci, Tobin","role":"aut","given":"Tobin"},{"family":"Rasmussen","display":"Rasmussen, Lone Brink","role":"aut","given":"Lone Brink"},{"display":"Sujan, Mohammad Julhas","family":"Sujan","given":"Mohammad Julhas","role":"aut"},{"given":"Patrícia","role":"aut","display":"Teixeira Dos Santos, Patrícia","family":"Teixeira Dos Santos"},{"role":"aut","given":"Rangsiya","family":"Prathan","display":"Prathan, Rangsiya"},{"family":"Luangtongkum","display":"Luangtongkum, Taradon","role":"aut","given":"Taradon"},{"family":"Chanchaitong","display":"Chanchaitong, Pattrarat","role":"aut","given":"Pattrarat"},{"role":"aut","given":"Pitak","family":"Santanirand","display":"Santanirand, Pitak"},{"family":"Kamjumpho","display":"Kamjumpho, Watcharaporn","role":"aut","given":"Watcharaporn"},{"display":"Mogeni, Ondari D","family":"Mogeni","given":"Ondari D","role":"aut"},{"display":"Holm, Marianne","family":"Holm","given":"Marianne","role":"aut"},{"given":"Florian","role":"aut","display":"Marks, Florian","family":"Marks"},{"given":"Rungtip","role":"aut","display":"Chuanchuen, Rungtip","family":"Chuanchuen"},{"family":"Hendriksen","display":"Hendriksen, Rene S","role":"aut","given":"Rene S"},{"display":"Poudyal, Nimesh","family":"Poudyal","given":"Nimesh","role":"aut"}]} | ||
| SRT | |a ABEGAZFRESSTRENGTHEN2025 | ||