Investigation of the association of serum GFAP and NfL with brain and upper cervical MRI volumes in AQP4-IgG-positive NMOSD and MOGAD
Background: Serum glial fibrillary acidic protein (sGFAP) is associated with disease activity in aquaporin-4-immunoglobulin G-seropositive neuromyelitis optica spectrum disorders (AQP4-IgG+NMOSD). Serum neurofilament light chain (sNfL) is a biomarker for neuroaxonal damage. However, the association...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 20, 2025
|
| In: |
Therapeutic advances in neurological disorders
Year: 2025, Jahrgang: 18, Pages: 1-15 |
| ISSN: | 1756-2864 |
| DOI: | 10.1177/17562864251345792 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1177/17562864251345792 Verlag, kostenfrei, Volltext: https://journals.sagepub.com/doi/10.1177/17562864251345792 
|
| Verfasserangaben: | Patrick Schindler, Ulrike Grittner, Rebekka Rust, Susanna Asseyer, Judith Bellmann-Strobl, Tanja Schmitz-Hübsch, Michael Scheel, Sven Jarius, Brigitte Wildemann, Markus Reindl, Pascal Benkert, Jens Kuhle, Friedemann Paul, Klemens Ruprecht and Claudia Chien |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1945991062 | ||
| 003 | DE-627 | ||
| 005 | 20251212133841.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251212s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/17562864251345792 |2 doi | |
| 035 | |a (DE-627)1945991062 | ||
| 035 | |a (DE-599)KXP1945991062 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schindler, Patrick |e VerfasserIn |0 (DE-588)1279625066 |0 (DE-627)183275622X |4 aut | |
| 245 | 1 | 0 | |a Investigation of the association of serum GFAP and NfL with brain and upper cervical MRI volumes in AQP4-IgG-positive NMOSD and MOGAD |c Patrick Schindler, Ulrike Grittner, Rebekka Rust, Susanna Asseyer, Judith Bellmann-Strobl, Tanja Schmitz-Hübsch, Michael Scheel, Sven Jarius, Brigitte Wildemann, Markus Reindl, Pascal Benkert, Jens Kuhle, Friedemann Paul, Klemens Ruprecht and Claudia Chien |
| 264 | 1 | |c July 20, 2025 | |
| 300 | |b Diagramme | ||
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.12.2025 | ||
| 520 | |a Background: Serum glial fibrillary acidic protein (sGFAP) is associated with disease activity in aquaporin-4-immunoglobulin G-seropositive neuromyelitis optica spectrum disorders (AQP4-IgG+NMOSD). Serum neurofilament light chain (sNfL) is a biomarker for neuroaxonal damage. However, the association of sGFAP and sNfL with magnetic resonance imaging (MRI) volumes in AQP4-IgG+NMOSD is unclear. - Objectives: To investigate the associations of sGFAP and sNfL with brain MRI volumes in AQP4-IgG+NMOSD. - Design: Monocentric, retrospective, observational study. - Methods: In 33 clinically stable patients with AQP4-IgG+NMOSD, 17 patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and 15 healthy controls (HC), sGFAP and sNfL were measured at 2 (HC = 1) and 3-Tesla MRIs were obtained at 4 (HC = 1) yearly visits. Associations between biomarkers and MRI metrics were evaluated using linear models. - Results: In AQP4-IgG+NMOSD, but not in MOGAD and HC, higher sGFAP was associated with lower hippocampus (β = −2.0 (95% confidence interval: −3.4, −0.7), p = 0.004) and thalamus volumes (β = −2.5 (−4.3, −0.7), p = 0.006) and higher MRI cerebrospinal fluid volume (β = 1.8 (0.7, 3.2), p = 0.01), and, statistically less robust, with lower whole brain (β = −2.3 (−5.3, 0.8), p = 0.15) and gray matter volumes (β = −1.8 (−4.0, 0.4), p = 0.10). Furthermore, higher sGFAP (β = −0.06 (−0.11, −0.002), p = 0.04), but not sNfL (β = −0.02 (−0.08, 0.03), p = 0.38), was associated with percent brain volume change in AQP4-IgG+NMOSD. - Conclusion: The specific associations of sGFAP with brain MRI volumes corroborate sGFAP as a biomarker for disease activity in AQP4-IgG+NMOSD. | ||
| 700 | 1 | |a Grittner, Ulrike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rust, Rebekka |e VerfasserIn |4 aut | |
| 700 | 1 | |a Asseyer, Susanna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bellmann-Strobl, Judith |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmitz-Hübsch, Tanja |e VerfasserIn |4 aut | |
| 700 | 1 | |a Scheel, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jarius, Sven |e VerfasserIn |0 (DE-588)1054615918 |0 (DE-627)791654818 |0 (DE-576)410367478 |4 aut | |
| 700 | 1 | |a Wildemann, Brigitte |e VerfasserIn |0 (DE-588)110203844 |0 (DE-627)510150004 |0 (DE-576)171831330 |4 aut | |
| 700 | 1 | |a Reindl, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Benkert, Pascal |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kuhle, Jens |e VerfasserIn |4 aut | |
| 700 | 1 | |a Paul, Friedemann |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ruprecht, Klemens |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chien, Claudia |e VerfasserIn |0 (DE-588)1230352899 |0 (DE-627)175270052X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Therapeutic advances in neurological disorders |d London [u.a.] : Sage, 2008 |g 18(2025), Seite 1-15 |h Online-Ressource |w (DE-627)573753849 |w (DE-600)2442245-9 |w (DE-576)305897357 |x 1756-2864 |7 nnas |a Investigation of the association of serum GFAP and NfL with brain and upper cervical MRI volumes in AQP4-IgG-positive NMOSD and MOGAD |
| 773 | 1 | 8 | |g volume:18 |g year:2025 |g pages:1-15 |g extent:15 |a Investigation of the association of serum GFAP and NfL with brain and upper cervical MRI volumes in AQP4-IgG-positive NMOSD and MOGAD |
| 856 | 4 | 0 | |u https://doi.org/10.1177/17562864251345792 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://journals.sagepub.com/doi/10.1177/17562864251345792 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20251212 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 110203844 |a Wildemann, Brigitte |m 110203844:Wildemann, Brigitte |d 910000 |d 911100 |d 50000 |e 910000PW110203844 |e 911100PW110203844 |e 50000PW110203844 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 9 | ||
| 998 | |g 1054615918 |a Jarius, Sven |m 1054615918:Jarius, Sven |d 910000 |d 911100 |d 50000 |e 910000PJ1054615918 |e 911100PJ1054615918 |e 50000PJ1054615918 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 8 | ||
| 999 | |a KXP-PPN1945991062 |e 4826993242 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Patrick Schindler, Ulrike Grittner, Rebekka Rust, Susanna Asseyer, Judith Bellmann-Strobl, Tanja Schmitz-Hübsch, Michael Scheel, Sven Jarius, Brigitte Wildemann, Markus Reindl, Pascal Benkert, Jens Kuhle, Friedemann Paul, Klemens Ruprecht and Claudia Chien"]},"id":{"eki":["1945991062"],"doi":["10.1177/17562864251345792"]},"physDesc":[{"noteIll":"Diagramme","extent":"15 S."}],"recId":"1945991062","origin":[{"dateIssuedDisp":"July 20, 2025","dateIssuedKey":"2025"}],"person":[{"family":"Schindler","role":"aut","given":"Patrick","display":"Schindler, Patrick"},{"family":"Grittner","given":"Ulrike","role":"aut","display":"Grittner, Ulrike"},{"display":"Rust, Rebekka","family":"Rust","role":"aut","given":"Rebekka"},{"role":"aut","given":"Susanna","family":"Asseyer","display":"Asseyer, Susanna"},{"display":"Bellmann-Strobl, Judith","family":"Bellmann-Strobl","given":"Judith","role":"aut"},{"display":"Schmitz-Hübsch, Tanja","family":"Schmitz-Hübsch","given":"Tanja","role":"aut"},{"display":"Scheel, Michael","role":"aut","given":"Michael","family":"Scheel"},{"display":"Jarius, Sven","family":"Jarius","given":"Sven","role":"aut"},{"display":"Wildemann, Brigitte","family":"Wildemann","role":"aut","given":"Brigitte"},{"display":"Reindl, Markus","role":"aut","given":"Markus","family":"Reindl"},{"family":"Benkert","given":"Pascal","role":"aut","display":"Benkert, Pascal"},{"display":"Kuhle, Jens","role":"aut","given":"Jens","family":"Kuhle"},{"display":"Paul, Friedemann","role":"aut","given":"Friedemann","family":"Paul"},{"given":"Klemens","role":"aut","family":"Ruprecht","display":"Ruprecht, Klemens"},{"role":"aut","given":"Claudia","family":"Chien","display":"Chien, Claudia"}],"relHost":[{"disp":"Investigation of the association of serum GFAP and NfL with brain and upper cervical MRI volumes in AQP4-IgG-positive NMOSD and MOGADTherapeutic advances in neurological disorders","physDesc":[{"extent":"Online-Ressource"}],"recId":"573753849","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"Therapeutic advances in neurological disorders","title":"Therapeutic advances in neurological disorders"}],"part":{"extent":"15","volume":"18","text":"18(2025), Seite 1-15","year":"2025","pages":"1-15"},"id":{"zdb":["2442245-9"],"eki":["573753849"],"issn":["1756-2864"]},"pubHistory":["1.2008 -"],"origin":[{"publisherPlace":"London [u.a.]","dateIssuedKey":"2008","dateIssuedDisp":"2008-","publisher":"Sage"}]}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"note":["Gesehen am 12.12.2025"],"title":[{"title_sort":"Investigation of the association of serum GFAP and NfL with brain and upper cervical MRI volumes in AQP4-IgG-positive NMOSD and MOGAD","title":"Investigation of the association of serum GFAP and NfL with brain and upper cervical MRI volumes in AQP4-IgG-positive NMOSD and MOGAD"}]} | ||
| SRT | |a SCHINDLERPINVESTIGAT2020 | ||