Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity
Our brain is bathed in cerebrospinal fluid (CSF) that is produced by the choroid plexus. CSF serves as a dispersion route for hormones and nutrients, and a conduit for waste clearance. Age-dependent reduction in the CSF secretion rate could influence cerebral waste clearance and thereby promote cogn...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 July 2025
|
| In: |
Nature Communications
Year: 2025, Jahrgang: 16, Pages: 1-16 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-025-61889-6 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-61889-6 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-61889-6 
|
| Verfasserangaben: | Sara D. Lolansen, Eszter O. Révész, Søren N. Andreassen, Marleen Trapp, Chiara Salio, Marco Sassoé-Pognetto, Jens Velde Andersen, Emil W. Westi, Trine L. Toft-Bertelsen, Jonathan H. Wardman, Anne-Kristine Meinild Lundby, Flemming Dela, Annarita Patrizi, Blanca I. Aldana & Nanna MacAulay |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1946026808 | ||
| 003 | DE-627 | ||
| 005 | 20251215082859.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251215s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-025-61889-6 |2 doi | |
| 035 | |a (DE-627)1946026808 | ||
| 035 | |a (DE-599)KXP1946026808 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lolansen, Sara D. |e VerfasserIn |0 (DE-588)1384359680 |0 (DE-627)1946027537 |4 aut | |
| 245 | 1 | 0 | |a Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity |c Sara D. Lolansen, Eszter O. Révész, Søren N. Andreassen, Marleen Trapp, Chiara Salio, Marco Sassoé-Pognetto, Jens Velde Andersen, Emil W. Westi, Trine L. Toft-Bertelsen, Jonathan H. Wardman, Anne-Kristine Meinild Lundby, Flemming Dela, Annarita Patrizi, Blanca I. Aldana & Nanna MacAulay |
| 264 | 1 | |c 23 July 2025 | |
| 300 | |b Illustrationen, Diagramme | ||
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.12.2025 | ||
| 520 | |a Our brain is bathed in cerebrospinal fluid (CSF) that is produced by the choroid plexus. CSF serves as a dispersion route for hormones and nutrients, and a conduit for waste clearance. Age-dependent reduction in the CSF secretion rate could influence cerebral waste clearance and thereby promote cognitive deficits in the elderly. Here, we resolve age-dependent modulation of CSF dynamics and choroid plexus function by complementary in vivo determinations of intracranial pressure (ICP) and CSF secretion/absorption rates, combined with transcriptomic, morphological, and metabolic analysis of choroid plexus in aging male rats. ICP and CSF secretion rate and absorption capacity remain stable with age, and the choroid plexus retains its morphology, structural integrity, gene expression, and high metabolic rate across the tested ages. This work supports the significance of choroid plexus function for brain aging and promotes this tissue as a future target for neurodegenerative diseases associated with impaired waste clearance and cognitive decline. | ||
| 650 | 4 | |a Blood-brain barrier | |
| 650 | 4 | |a Neurology | |
| 700 | 1 | |a Révész, Eszter O. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Andreassen, Søren N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Trapp, Marleen |e VerfasserIn |0 (DE-588)1380207061 |0 (DE-627)1939670640 |4 aut | |
| 700 | 1 | |a Salio, Chiara |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sassoé-Pognetto, Marco |e VerfasserIn |4 aut | |
| 700 | 1 | |a Andersen, Jens Velde |e VerfasserIn |4 aut | |
| 700 | 1 | |a Westi, Emil W. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Toft-Bertelsen, Trine L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wardman, Jonathan H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lundby, Anne-Kristine Meinild |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dela, Flemming |e VerfasserIn |4 aut | |
| 700 | 1 | |a Patrizi, Annarita |e VerfasserIn |0 (DE-588)1230464336 |0 (DE-627)1752825187 |4 aut | |
| 700 | 1 | |a Aldana, Blanca I. |e VerfasserIn |4 aut | |
| 700 | 1 | |a MacAulay, Nanna |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 16(2025), Artikel-ID 6778, Seite 1-16 |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity |
| 773 | 1 | 8 | |g volume:16 |g year:2025 |g elocationid:6778 |g pages:1-16 |g extent:16 |a Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41467-025-61889-6 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41467-025-61889-6 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20251215 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1230464336 |a Patrizi, Annarita |m 1230464336:Patrizi, Annarita |d 700000 |d 712000 |e 700000PP1230464336 |e 712000PP1230464336 |k 0/700000/ |k 1/700000/712000/ |p 13 | ||
| 998 | |g 1380207061 |a Trapp, Marleen |m 1380207061:Trapp, Marleen |p 4 | ||
| 999 | |a KXP-PPN1946026808 |e 4827995419 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 15.12.2025"],"recId":"1946026808","language":["eng"],"person":[{"display":"Lolansen, Sara D.","roleDisplay":"VerfasserIn","role":"aut","family":"Lolansen","given":"Sara D."},{"given":"Eszter O.","family":"Révész","role":"aut","display":"Révész, Eszter O.","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Andreassen, Søren N.","given":"Søren N.","family":"Andreassen"},{"roleDisplay":"VerfasserIn","display":"Trapp, Marleen","role":"aut","family":"Trapp","given":"Marleen"},{"given":"Chiara","family":"Salio","role":"aut","roleDisplay":"VerfasserIn","display":"Salio, Chiara"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Sassoé-Pognetto, Marco","given":"Marco","family":"Sassoé-Pognetto"},{"display":"Andersen, Jens Velde","roleDisplay":"VerfasserIn","role":"aut","family":"Andersen","given":"Jens Velde"},{"display":"Westi, Emil W.","roleDisplay":"VerfasserIn","role":"aut","family":"Westi","given":"Emil W."},{"display":"Toft-Bertelsen, Trine L.","roleDisplay":"VerfasserIn","role":"aut","family":"Toft-Bertelsen","given":"Trine L."},{"display":"Wardman, Jonathan H.","roleDisplay":"VerfasserIn","role":"aut","family":"Wardman","given":"Jonathan H."},{"display":"Lundby, Anne-Kristine Meinild","roleDisplay":"VerfasserIn","role":"aut","family":"Lundby","given":"Anne-Kristine Meinild"},{"roleDisplay":"VerfasserIn","display":"Dela, Flemming","role":"aut","family":"Dela","given":"Flemming"},{"role":"aut","display":"Patrizi, Annarita","roleDisplay":"VerfasserIn","given":"Annarita","family":"Patrizi"},{"given":"Blanca I.","family":"Aldana","role":"aut","display":"Aldana, Blanca I.","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"MacAulay, Nanna","role":"aut","family":"MacAulay","given":"Nanna"}],"title":[{"title_sort":"Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity","title":"Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity"}],"physDesc":[{"extent":"16 S.","noteIll":"Illustrationen, Diagramme"}],"relHost":[{"id":{"issn":["2041-1723"],"eki":["626457688"],"zdb":["2553671-0"]},"origin":[{"publisherPlace":"[London] ; [London]","dateIssuedDisp":"[2010]-","publisher":"Springer Nature ; Nature Publishing Group UK"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Nature Communications","title":"Nature Communications"}],"part":{"year":"2025","pages":"1-16","text":"16(2025), Artikel-ID 6778, Seite 1-16","volume":"16","extent":"16"},"pubHistory":["2010-"],"recId":"626457688","language":["eng"],"note":["Gesehen am 13.06.24"],"disp":"Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activityNature Communications","type":{"bibl":"periodical","media":"Online-Ressource"}}],"name":{"displayForm":["Sara D. Lolansen, Eszter O. Révész, Søren N. Andreassen, Marleen Trapp, Chiara Salio, Marco Sassoé-Pognetto, Jens Velde Andersen, Emil W. Westi, Trine L. Toft-Bertelsen, Jonathan H. Wardman, Anne-Kristine Meinild Lundby, Flemming Dela, Annarita Patrizi, Blanca I. Aldana & Nanna MacAulay"]},"origin":[{"dateIssuedDisp":"23 July 2025","dateIssuedKey":"2025"}],"id":{"eki":["1946026808"],"doi":["10.1038/s41467-025-61889-6"]}} | ||
| SRT | |a LOLANSENSACHOROIDPLE2320 | ||