Incidence and predictors of Woven EndoBridge (WEB) shape modification following treatment of intracranial aneurysms in a large multicenter study

The Woven EndoBridge (WEB) device is FDA-approved for the treatment of bifurcation aneurysms. Despite its wide popularity, it has been under scrutiny for its association with potential aneurysm recanalization and retreatment due to device shape modification. This study aims to analyze the shape modi...

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Hauptverfasser: Adeeb, Nimer (VerfasserIn) , Salim, Hamza (VerfasserIn) , Musmar, Basel (VerfasserIn) , Aslan, Assala (VerfasserIn) , Swaid, Christian (VerfasserIn) , Cuellar, Miguel (VerfasserIn) , Dibas, Mahmoud (VerfasserIn) , Cancelliere, Nicole M. (VerfasserIn) , Diestro, Jose Danilo Bengzon (VerfasserIn) , Algin, Oktay (VerfasserIn) , Ghozy, Sherief (VerfasserIn) , Lay, Sovann V. (VerfasserIn) , Guenego, Adrien (VerfasserIn) , Renieri, Leonardo (VerfasserIn) , Carnevale, Joseph (VerfasserIn) , Saliou, Guillaume (VerfasserIn) , Mastorakos, Panagiotis (VerfasserIn) , Naamani, Kareem El (VerfasserIn) , Shotar, Eimad (VerfasserIn) , Möhlenbruch, Markus Alfred (VerfasserIn) , Kral, Michael (VerfasserIn) , Chung, Charlotte (VerfasserIn) , Salem, Mohamed M. (VerfasserIn) , Lylyk, Ivan (VerfasserIn) , Foreman, Paul M. (VerfasserIn) , Shaikh, Hamza (VerfasserIn) , Župančić, Vedran (VerfasserIn) , Hafeez, Muhammad U. (VerfasserIn) , Catapano, Joshua (VerfasserIn) , Waqas, Muhammad (VerfasserIn) , Arslan, Muhammet (VerfasserIn) , Ergun, Onur (VerfasserIn) , Rabinov, James D. (VerfasserIn) , Ren, Yifan (VerfasserIn) , Schirmer, Clemens Maria (VerfasserIn) , Piano, Mariangela (VerfasserIn) , Kühn, Anna L. (VerfasserIn) , Michelozzi, Caterina (VerfasserIn) , Starke, Robert M. (VerfasserIn) , Hassan, Ameer (VerfasserIn) , Ogilvie, Mark (VerfasserIn) , Nguyen, Anh (VerfasserIn) , Jones, Jesse (VerfasserIn) , Brinjikji, Waleed (VerfasserIn) , Nawka, Marie T. (VerfasserIn) , Psychogios, Marios (VerfasserIn) , Ulfert, Christian (VerfasserIn) , Pukenas, Bryan (VerfasserIn) , Burkhardt, Jan-Karl (VerfasserIn) , Huynh, Thien (VerfasserIn) , Martinez-Gutierrez, Juan Carlos (VerfasserIn) , Essibayi, Muhammed Amir (VerfasserIn) , Sheth, Sunil A. (VerfasserIn) , Slawski, Diana (VerfasserIn) , Tawk, Rabih (VerfasserIn) , Pulli, Benjamin (VerfasserIn) , Lubicz, Boris (VerfasserIn) , Panni, Pietro (VerfasserIn) , Puri, Ajit S. (VerfasserIn) , Pero, Guglielmo (VerfasserIn) , Raz, Eytan (VerfasserIn) , Griessenauer, Christoph J. (VerfasserIn) , Asadi, Hamed (VerfasserIn) , Siddiqui, Adnan (VerfasserIn) , Levy, Elad I. (VerfasserIn) , Haranhalli, Neil (VerfasserIn) , Altschul, David (VerfasserIn) , Ducruet, Andrew F. (VerfasserIn) , Albuquerque, Felipe C. (VerfasserIn) , Regenhardt, Robert W. (VerfasserIn) , Stapleton, Christopher J. (VerfasserIn) , Kan, Peter (VerfasserIn) , Kalousek, Vladimir (VerfasserIn) , Lylyk, Pedro (VerfasserIn) , Boddu, Srikanth (VerfasserIn) , Knopman, Jared (VerfasserIn) , Tjoumakaris, Stavropoula I. (VerfasserIn) , Jabbour, Pascal M. (VerfasserIn) , Clarençon, Frédéric (VerfasserIn) , Limbucci, Nicola (VerfasserIn) , Yedavalli, Vivek (VerfasserIn) , Wintermark, Max (VerfasserIn) , Pereira, Vitor Mendes (VerfasserIn) , Patel, Aman B. (VerfasserIn) , Cuellar-Saenz, Hugo H. (VerfasserIn) , Dmytriw, Adam A. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 25 February 2025
In: Neurosurgical review
Year: 2025, Jahrgang: 48, Heft: 1, Pages: 1-13
ISSN:1437-2320
DOI:10.1007/s10143-025-03344-0
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s10143-025-03344-0
Volltext
Verfasserangaben:Nimer Adeeb, Hamza Adel Salim, Basel Musmar, Assala Aslan, Christian Swaid, Miguel Cuellar, et al. [full author details at the end of the article]

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245 1 0 |a Incidence and predictors of Woven EndoBridge (WEB) shape modification following treatment of intracranial aneurysms in a large multicenter study  |c Nimer Adeeb, Hamza Adel Salim, Basel Musmar, Assala Aslan, Christian Swaid, Miguel Cuellar, et al. [full author details at the end of the article] 
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500 |a Authors and Affiliations: Mahmoud Dibas, Nicole M. Cancelliere, Jose Danilo Bengzon Diestro, Oktay Algin, Sherief Ghozy, Sovann V. Lay, Adrien Guenego, Leonardo Renieri, Joseph Carnevale, Guillaume Saliou, Panagiotis Mastorakos, Kareem El Naamani, Eimad Shotar, Markus Möhlenbruch, Michael Kral, Charlotte Chung, Mohamed M. Salem, Ivan Lylyk, Paul M. Foreman, Hamza Shaikh, Vedran Župančić, Muhammad U. Hafeez, Joshua Catapano, Muhammad Waqas, Muhammet Arslan, Onur Ergun, James D. Rabinov, Yifan Ren, Clemens M. Schirmer, Mariangela Piano, Anna L. Kühn, Caterina Michelozzi, Robert M. Starke, Ameer Hassan, Mark Ogilvie, Anh Nguyen, Jesse Jones, Waleed Brinjikji, Marie T. Nawka, Marios Psychogios, Christian Ulfert, Bryan Pukenas, Jan-Karl Burkhardt, Thien Huynh, Juan Carlos Martinez-Gutierrez, Muhammed Amir Essibayi, Sunil A. Sheth, Diana Slawski, Rabih Tawk, Benjamin Pulli, Boris Lubicz, Pietro Panni, Ajit S. Puri, Guglielmo Pero, Eytan Raz, Christoph J. Griessenauer, Hamed Asadi, Adnan Siddiqui, Elad I. Levy, Neil Haranhalli, David Altschul, Andrew F. Ducruet, Felipe C. Albuquerque, Robert W. Regenhardt, Christopher J. Stapleton, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Stavropoula I. Tjoumakaris, Pascal M. Jabbour, Frédéric Clarençon, Nicola Limbucci, Vivek Yedavalli, Max Wintermark, Vitor Mendes Pereira, Aman B. Patel, Hugo H. Cuellar-Saenz, Adam A. Dmytriw on behalf of the Worldwide Web Workgroup 
500 |a Gesehen am 15.12.2025 
520 |a The Woven EndoBridge (WEB) device is FDA-approved for the treatment of bifurcation aneurysms. Despite its wide popularity, it has been under scrutiny for its association with potential aneurysm recanalization and retreatment due to device shape modification. This study aims to analyze the shape modification rate of WEB devices and identify factors associated with this phenomenon, as well as its correlation with aneurysm retreatment. We conducted a retrospective review of the WorldWide WEB Consortium database, including adult patients treated for intracranial aneurysms with the WEB device. We assessed aneurysm occlusion using the WEB Occlusion Scale and defined WEB shape modification as a percentage reduction in the distance between two WEB markers. Logistic regression and Cox proportional hazards models were utilized to evaluate predictors of shape modification and retreatment. Kaplan-Meier curves were used to estimate the time-dependent probability of no or minor shape modification. A total of 405 patients were analyzed, with minor and major shape modification occurring in 31.4% and 10.1% of cases, respectively. Major shape modification was associated with lower rates of adequate occlusion (70.7%) compared to no or minor shape modification (86.6%) and a higher rate of retreatment (26.8% vs. 8.1%). Predictors of major shape modification included the presence of daughter sac, bifurcation aneurysms, absence of immediate flow stagnation, and a WEB width minus aneurysm width ratio ≤ 0.5. The probability of no or minor shape modification declined within the first 25 months and stabilized thereafter. WEB device shape modification is a significant predictor of aneurysm occlusion efficacy and retreatment. Recognizing the factors influencing shape modification can guide treatment decisions and follow-up protocols to improve patient outcomes. 
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650 4 |a Endovascular 
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Cancelliere, Jose Danilo Bengzon Diestro, Oktay Algin, Sherief Ghozy, Sovann V. Lay, Adrien Guenego, Leonardo Renieri, Joseph Carnevale, Guillaume Saliou, Panagiotis Mastorakos, Kareem El Naamani, Eimad Shotar, Markus Möhlenbruch, Michael Kral, Charlotte Chung, Mohamed M. Salem, Ivan Lylyk, Paul M. Forema 
JSO |a n, Hamza Shaikh, Vedran Župančić, Muhammad U. Hafeez, Joshua Catapano, Muhammad Waqas, Muhammet Arslan, Onur Ergun, James D. Rabinov, Yifan Ren, Clemens M. Schirmer, Mariangela Piano, Anna L. Kühn, Caterina Michelozzi, Robert M. Starke, Ameer Hassan, Mark Ogilvie, Anh Nguyen, Jesse Jones, Waleed Brinjikji, Marie T. Nawka, Marios Psychogios, Christian Ulfert, Bryan Pukenas, Jan-Karl Burkhardt, Thien Huynh, Juan Carlos Martinez-Gutierrez, Muhammed Amir Essibayi, Sunil A. Sheth, Diana Slawski, Rabih Tawk, Benjamin Pulli, Boris Lubicz, Pietro Panni, Ajit S. Puri, Guglielmo Pero, Eytan Raz, Christoph J. Griessenauer, Hamed Asadi, Adnan Siddiqui, Elad I. Levy, Neil Haranhalli, David Altschul, Andrew F. Ducruet, Felipe C. Albuquerque, Robert W. Regenhardt, Christopher J. Stapleton, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Stavropoula I. Tjoumakaris, Pascal M. Jabbour, Frédéric Clarençon, Nicola Limbucci, Vivek Yedavalli, Max Wintermark, Vitor Mendes Pereira, Aman B. Patel, Hugo H. Cuellar-Saenz, Adam A. Dmytriw on behalf of the Worldwide Web Workgroup","Gesehen am 15.12.2025"]} 
SRT |a ADEEBNIMERINCIDENCEA2520