Targeting CD276 with Adapter-CAR T-cells provides a novel therapeutic strategy in small cell lung cancer and prevents CD276-dependent fratricide
Survival rates in Small Cell Lung Cancer (SCLC) remain dismal, posing a huge medical need for novel therapies. T-cells, engineered to express chimeric antigen receptors (CAR-T) have demonstrated clinical activity against a variety of haematological malignancies. Yet, efficacy against solid tumour en...
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| Hauptverfasser: | , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 July 2025
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| In: |
Journal of hematology & oncology
Year: 2025, Jahrgang: 18, Heft: 1, Pages: 1-18 |
| ISSN: | 1756-8722 |
| DOI: | 10.1186/s13045-025-01729-8 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13045-025-01729-8 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1186/s13045-025-01729-8?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate 
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| Verfasserangaben: | Beate Kristmann, Niels Werchau, Lakshmi Suresh, Elisabeth L. Pezzuto, Sophia Scheuermann, Simon Krost, Karin Schilbach, Moustafa Moustafa-Oglou, Anna-Sophia Mast, Miriam Droste, André Felsberger, Lukas Kiefer, Pierre Abramowski, Lars Zender, Joerg Mittelstaet and Christian M. Seitz |
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