Intercellular communication in the brain through a dendritic nanotubular network
Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite-dendrite nanotubes (DNTs) in mammalian cortex. Super-resolution microscopy in dissociated neurons reveal...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2, 2025
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| In: |
Science
Year: 2025, Jahrgang: 390, Heft: 6768, Pages: 1-17 |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.adr7403 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.adr7403 Verlag, lizenzpflichtig, Volltext: https://www-science-org.ezproxy.medma.uni-heidelberg.de/doi/10.1126/science.adr7403 
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| Verfasserangaben: | Minhyeok Chang, Sarah Krüssel, Laxmi Kumar Parajuli, Juhyun Kim, Daniel Lee, Alec Merodio, Jaeyoung Kwon, Shigeo Okabe, Hyung-Bae Kwon |
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| 520 | |a Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite-dendrite nanotubes (DNTs) in mammalian cortex. Super-resolution microscopy in dissociated neurons revealed DNTs’ actin-rich composition and dynamics, enabling long-range calcium ion (Ca2+) propagation. Imaging and machine learning-based analysis validated in situ DNTs as anatomically distinct from synaptic spines. DNTs actively transported small molecules and human amyloid-β (Aβ); DNT density increased before plaque formation in the medial prefrontal cortex of APP/PS1 mice (APP, Aβ precursor protein; PS1, presenilin-1), suggesting that the dendrite-DNT network might play a role in Alzheimer’s disease pathology. Computational models of DNT-mediated Aβ propagation recapitulated early amyloidosis, predicting selective intracellular accumulation. These findings uncover a nanotubular connectivity layer in the brain, extending neuronal communication beyond classical synapses. | ||
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