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COMP-Ang-1 improves glucose uptake in db/db mice with Type 2 Diabetes

<p>Cartilage oligomeric matrix protein (COMP)-Angiopoietin-1 is a potent angiopoietin-1 (Ang-1) variant that possesses therapeutic potential in angiogenesis and vascular endothelial dysfunction. Noteworthy, we have shown that COMP-Ang-1 improves hyperglycemia and neuroregeneration in <i>...

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Main Authors: Baum, Petra (Author) , Paeschke, Sabine (Author) , Klöting-Blüher, Nora (Author) , Blüher, Matthias (Author) , Kern, Matthias (Author) , Serke, Heike (Author) , Nowicki, Marcin (Author) , Kosacka-Esmailpour, Joanna (Author)
Format: Article (Journal)
Language:English
Published: September 2020
In: Hormone and metabolic research
Year: 2020, Volume: 52, Issue: 09, Pages: 685-688
ISSN:1439-4286
DOI:10.1055/a-1126-4402
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1055/a-1126-4402
Verlag, lizenzpflichtig, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/a-1126-4402
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Author Notes:Petra Baum, Sabine Paeschke, Nora Klöting, Matthias Blüher, Matthias Kern, Heike Serke, Marcin Nowicki, Joanna Kosacka
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Summary:<p>Cartilage oligomeric matrix protein (COMP)-Angiopoietin-1 is a potent angiopoietin-1 (Ang-1) variant that possesses therapeutic potential in angiogenesis and vascular endothelial dysfunction. Noteworthy, we have shown that COMP-Ang-1 improves hyperglycemia and neuroregeneration in <i>ob</i>/<i>ob</i> mice. However, the mechanism of the antidiabetic effect of COMP-Ang-1 is completely unknown. Therefore, we elucidated the diabetes protective molecular mechanisms of COMP-Ang-1 in diabetic <i>db</i>/<i>db</i> mouse model. COMP-Ang-1 (0.5 ng/g body weight) or aqueous NaCl solution was injected intraperitoneally per day in 21 consecutive days into 3-month old, male <i>db</i>/<i>db</i> mice (n=10 per group). Blood glucose and HbA1c levels were determined at baseline and 21 days after COMP-Ang-1 or NaCl treatment. The effect of COMP-Ang-1 on glucose uptake was investigated by euglycemic-hyperinsulinemic clamp studies and key genes of glucose metabolism were studied by Western blot analysis. Our findings indicate that COMP-Ang-1 improves glucose metabolism in a tissue specific manner by regulating HIF-1α transcriptional genes of GLUT-1 expression.</p>
Item Description:Gesehen am 22.12.2025
Physical Description:Online Resource
ISSN:1439-4286
DOI:10.1055/a-1126-4402

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