Cover Image

COMP-Ang-1 improves glucose uptake in db/db mice with Type 2 Diabetes

<p>Cartilage oligomeric matrix protein (COMP)-Angiopoietin-1 is a potent angiopoietin-1 (Ang-1) variant that possesses therapeutic potential in angiogenesis and vascular endothelial dysfunction. Noteworthy, we have shown that COMP-Ang-1 improves hyperglycemia and neuroregeneration in <i>...

Full description

Saved in:
Bibliographic Details
Main Authors: Baum, Petra (Author) , Paeschke, Sabine (Author) , Klöting-Blüher, Nora (Author) , Blüher, Matthias (Author) , Kern, Matthias (Author) , Serke, Heike (Author) , Nowicki, Marcin (Author) , Kosacka-Esmailpour, Joanna (Author)
Format: Article (Journal)
Language:English
Published: September 2020
In: Hormone and metabolic research
Year: 2020, Volume: 52, Issue: 09, Pages: 685-688
ISSN:1439-4286
DOI:10.1055/a-1126-4402
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1055/a-1126-4402
Verlag, lizenzpflichtig, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/a-1126-4402
Get full text
Author Notes:Petra Baum, Sabine Paeschke, Nora Klöting, Matthias Blüher, Matthias Kern, Heike Serke, Marcin Nowicki, Joanna Kosacka

MARC

LEADER 00000naa a22000002c 4500
001 1947516647
003 DE-627
005 20251222151405.0
007 cr uuu---uuuuu
008 251222s2020 xx |||||o 00| ||eng c
024 7 |a 10.1055/a-1126-4402  |2 doi 
035 |a (DE-627)1947516647 
035 |a (DE-599)KXP1947516647 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Baum, Petra  |d 1968-  |e VerfasserIn  |0 (DE-588)1103518429  |0 (DE-627)86127279X  |0 (DE-576)470645490  |4 aut 
245 1 0 |a COMP-Ang-1 improves glucose uptake in db/db mice with Type 2 Diabetes  |c Petra Baum, Sabine Paeschke, Nora Klöting, Matthias Blüher, Matthias Kern, Heike Serke, Marcin Nowicki, Joanna Kosacka 
246 3 0 |a One two 
246 3 3 |a COMP Ang 1 improves glucose uptake in db, db mice with Type 2 Diabetes 
264 1 |c September 2020 
300 |a 4 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 22.12.2025 
520 |a <p>Cartilage oligomeric matrix protein (COMP)-Angiopoietin-1 is a potent angiopoietin-1 (Ang-1) variant that possesses therapeutic potential in angiogenesis and vascular endothelial dysfunction. Noteworthy, we have shown that COMP-Ang-1 improves hyperglycemia and neuroregeneration in <i>ob</i>/<i>ob</i> mice. However, the mechanism of the antidiabetic effect of COMP-Ang-1 is completely unknown. Therefore, we elucidated the diabetes protective molecular mechanisms of COMP-Ang-1 in diabetic <i>db</i>/<i>db</i> mouse model. COMP-Ang-1 (0.5 ng/g body weight) or aqueous NaCl solution was injected intraperitoneally per day in 21 consecutive days into 3-month old, male <i>db</i>/<i>db</i> mice (n=10 per group). Blood glucose and HbA1c levels were determined at baseline and 21 days after COMP-Ang-1 or NaCl treatment. The effect of COMP-Ang-1 on glucose uptake was investigated by euglycemic-hyperinsulinemic clamp studies and key genes of glucose metabolism were studied by Western blot analysis. Our findings indicate that COMP-Ang-1 improves glucose metabolism in a tissue specific manner by regulating HIF-1α transcriptional genes of GLUT-1 expression.</p> 
700 1 |a Paeschke, Sabine  |d 1990-  |e VerfasserIn  |0 (DE-588)126514074X  |0 (DE-627)1814185488  |4 aut 
700 1 |a Klöting-Blüher, Nora  |d 1977-  |e VerfasserIn  |0 (DE-588)129840793  |0 (DE-627)707331005  |0 (DE-576)297863436  |4 aut 
700 1 |a Blüher, Matthias  |d 1970-  |e VerfasserIn  |0 (DE-588)120419068  |0 (DE-627)080663273  |0 (DE-576)178795291  |4 aut 
700 1 |a Kern, Matthias  |d 1980-  |e VerfasserIn  |0 (DE-588)1027192947  |0 (DE-627)728564440  |0 (DE-576)372578268  |4 aut 
700 1 |a Serke, Heike  |d 1976-  |e VerfasserIn  |0 (DE-588)131522000  |0 (DE-627)707653436  |0 (DE-576)254710557  |4 aut 
700 1 |a Nowicki, Marcin  |e VerfasserIn  |4 aut 
700 1 |a Kosacka-Esmailpour, Joanna  |d 1975-  |e VerfasserIn  |0 (DE-588)136721532  |0 (DE-627)69460819X  |0 (DE-576)28784840X  |4 aut 
773 0 8 |i Enthalten in  |t Hormone and metabolic research  |d Stuttgart [u.a.] : Thieme, 1969  |g 52(2020), 09, Seite 685-688  |h Online-Ressource  |w (DE-627)333809661  |w (DE-600)2056576-8  |w (DE-576)263593649  |x 1439-4286  |7 nnas  |a COMP-Ang-1 improves glucose uptake in db/db mice with Type 2 Diabetes 
773 1 8 |g volume:52  |g year:2020  |g number:09  |g pages:685-688  |g extent:4  |a COMP-Ang-1 improves glucose uptake in db/db mice with Type 2 Diabetes 
856 4 0 |u https://doi.org/10.1055/a-1126-4402  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext  |7 1 
856 4 0 |u http://www.thieme-connect.de/DOI/DOI?10.1055/a-1126-4402  |x Verlag  |z lizenzpflichtig  |3 Volltext  |7 1 
951 |a AR 
992 |a 20251222 
993 |a Article 
994 |a 2020 
998 |g 131522000  |a Serke, Heike  |m 131522000:Serke, Heike  |d 60000  |d 65000  |e 60000PS131522000  |e 65000PS131522000  |k 0/60000/  |k 1/60000/65000/  |p 6 
999 |a KXP-PPN1947516647  |e 4832353462 
BIB |a Y 
SER |a journal 
JSO |a {"physDesc":[{"extent":"4 S."}],"name":{"displayForm":["Petra Baum, Sabine Paeschke, Nora Klöting, Matthias Blüher, Matthias Kern, Heike Serke, Marcin Nowicki, Joanna Kosacka"]},"titleAlt":[{"title":"COMP Ang 1 improves glucose uptake in db, db mice with Type 2 Diabetes"}],"language":["eng"],"recId":"1947516647","title":[{"title":"COMP-Ang-1 improves glucose uptake in db/db mice with Type 2 Diabetes","title_sort":"COMP-Ang-1 improves glucose uptake in db/db mice with Type 2 Diabetes"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 22.12.2025"],"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"September 2020"}],"id":{"doi":["10.1055/a-1126-4402"],"eki":["1947516647"]},"person":[{"display":"Baum, Petra","roleDisplay":"VerfasserIn","role":"aut","family":"Baum","given":"Petra"},{"display":"Paeschke, Sabine","role":"aut","roleDisplay":"VerfasserIn","given":"Sabine","family":"Paeschke"},{"display":"Klöting-Blüher, Nora","roleDisplay":"VerfasserIn","role":"aut","given":"Nora","family":"Klöting-Blüher"},{"display":"Blüher, Matthias","roleDisplay":"VerfasserIn","role":"aut","family":"Blüher","given":"Matthias"},{"display":"Kern, Matthias","given":"Matthias","family":"Kern","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Serke","given":"Heike","roleDisplay":"VerfasserIn","role":"aut","display":"Serke, Heike"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Marcin","family":"Nowicki","display":"Nowicki, Marcin"},{"display":"Kosacka-Esmailpour, Joanna","given":"Joanna","family":"Kosacka-Esmailpour","role":"aut","roleDisplay":"VerfasserIn"}],"relHost":[{"disp":"COMP-Ang-1 improves glucose uptake in db/db mice with Type 2 DiabetesHormone and metabolic research","physDesc":[{"extent":"Online-Ressource"}],"part":{"pages":"685-688","extent":"4","issue":"09","text":"52(2020), 09, Seite 685-688","volume":"52","year":"2020"},"note":["Gesehen am 14.05.25"],"origin":[{"publisherPlace":"Stuttgart [u.a.]","dateIssuedKey":"1969","publisher":"Thieme","dateIssuedDisp":"1969-"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.1969 -"],"title":[{"title_sort":"Hormone and metabolic research","title":"Hormone and metabolic research"}],"language":["eng"],"recId":"333809661","titleAlt":[{"title":"Hormon- und Stoffwechselforschung"},{"title":"Hormones et métabolisme"}],"id":{"issn":["1439-4286"],"doi":["10.1055/s-00000025"],"eki":["333809661"],"zdb":["2056576-8"]}}]} 
SRT |a BAUMPETRAPCOMPANG1IM2020 

Similar Items