Making sense of astrocytic calcium signals: from acquisition to interpretation
Astrocytes functionally interact with neurons and with other brain cells. Although not electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling that evolves in space and time within single astrocytes and across astrocytic networks. Decoding the physiological m...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2020
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| In: |
Nature reviews. Neuroscience
Year: 2020, Jahrgang: 21, Pages: 551-564 |
| ISSN: | 1471-0048 |
| DOI: | 10.1038/s41583-020-0361-8 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41583-020-0361-8 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41583-020-0361-8 
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| Verfasserangaben: | Alexey Semyanov, Christian Henneberger and Amit Agarwal |
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| 520 | |a Astrocytes functionally interact with neurons and with other brain cells. Although not electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling that evolves in space and time within single astrocytes and across astrocytic networks. Decoding the physiological meaning of these dynamic changes in astrocytic Ca2+ activity has remained a major challenge. This Review describes experimental preparations and methods for recording and studying Ca2+ activity in astrocytes, focusing on the analysis of Ca2+ signalling events in single astrocytes and in astrocytic networks. The limitations of existing experimental approaches and ongoing technical and conceptual challenges in the interpretation of astrocytic Ca2+ events and their spatio-temporal patterns are also discussed. | ||
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