The immunology of brain tumors: cancer immunology
Brain tumors represent a unique challenge for cancer immunotherapies because of their location in an immune privileged site. However, the brain tumor immune microenvironment is dictated more by tumor type than the location within the brain per se. This feature is reflected by the higher immunogenici...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 Oct 2025
|
| In: |
Science immunology
Year: 2025, Jahrgang: 10, Heft: 112, Pages: ? |
| ISSN: | 2470-9468 |
| DOI: | 10.1126/sciimmunol.ads0449 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/sciimmunol.ads0449 Verlag, lizenzpflichtig, Volltext: https://www-science-org.ezproxy.medma.uni-heidelberg.de/doi/10.1126/sciimmunol.ads0449 
|
| Verfasserangaben: | Lukas Bunse, Theresa Bunse, Michael Kilian, Francisco J. Quintana, and Michael Platten |
MARC
| LEADER | 00000naa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1947770268 | ||
| 003 | DE-627 | ||
| 005 | 20260105162936.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260105s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1126/sciimmunol.ads0449 |2 doi | |
| 035 | |a (DE-627)1947770268 | ||
| 035 | |a (DE-599)KXP1947770268 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bunse, Lukas |d 1988- |e VerfasserIn |0 (DE-588)1051941229 |0 (DE-627)787187399 |0 (DE-576)407600426 |4 aut | |
| 245 | 1 | 4 | |a The immunology of brain tumors |b cancer immunology |c Lukas Bunse, Theresa Bunse, Michael Kilian, Francisco J. Quintana, and Michael Platten |
| 264 | 1 | |c 3 Oct 2025 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.01.2026 | ||
| 520 | |a Brain tumors represent a unique challenge for cancer immunotherapies because of their location in an immune privileged site. However, the brain tumor immune microenvironment is dictated more by tumor type than the location within the brain per se. This feature is reflected by the higher immunogenicity and response to immunotherapies of metastatic brain tumors compared with primary brain tumors. Immunotherapies for brain tumors aim at inducing and boosting tumor T cell responses using vaccines, immune checkpoint inhibitors, or adoptive T cell therapies. A fundamental challenge in the field is how such brain tumor-targeting T cells gain access to brain tumors and maintain their function despite a hostile immunosuppressive microenvironment. Here, we review current knowledge of the cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment. Expanding and exploiting this knowledge will provide the key for effective combinatorial therapies. | ||
| 700 | 1 | |a Bunse, Theresa |d 1985- |e VerfasserIn |0 (DE-588)105282112X |0 (DE-627)789079070 |0 (DE-576)408553731 |4 aut | |
| 700 | 1 | |a Kilian, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Quintana, Francisco J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Platten, Michael |d 1971- |e VerfasserIn |0 (DE-588)121627780 |0 (DE-627)081431848 |0 (DE-576)261969811 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Science immunology |d Washington, DC : AAAS, 2016 |g 10(2025), 112, Artikel-ID eads0449, Seite ? |h Online-Ressource |w (DE-627)863416853 |w (DE-600)2862556-0 |w (DE-576)475004736 |x 2470-9468 |7 nnas |a The immunology of brain tumors cancer immunology |
| 773 | 1 | 8 | |g volume:10 |g year:2025 |g number:112 |g elocationid:eads0449 |g pages:? |a The immunology of brain tumors cancer immunology |
| 787 | 0 | 8 | |i Errata |a Bunse, Lukas, 1988 - |t Erratum for the Review “The immunology of brain tumors” by L. Bunse et al. |d 2025 |w (DE-627)1947770586 |
| 856 | 4 | 0 | |u https://doi.org/10.1126/sciimmunol.ads0449 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |7 1 |
| 856 | 4 | 0 | |u https://www-science-org.ezproxy.medma.uni-heidelberg.de/doi/10.1126/sciimmunol.ads0449 |x Verlag |z lizenzpflichtig |3 Volltext |7 1 |
| 951 | |a AR | ||
| 992 | |a 20260105 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 121627780 |a Platten, Michael |m 121627780:Platten, Michael |d 60000 |d 62700 |e 60000PP121627780 |e 62700PP121627780 |k 0/60000/ |k 1/60000/62700/ |p 5 |y j | ||
| 998 | |g 105282112X |a Bunse, Theresa |m 105282112X:Bunse, Theresa |d 60000 |d 62700 |e 60000PB105282112X |e 62700PB105282112X |k 0/60000/ |k 1/60000/62700/ |p 2 | ||
| 998 | |g 1051941229 |a Bunse, Lukas |m 1051941229:Bunse, Lukas |d 60000 |d 62700 |d 60000 |e 60000PB1051941229 |e 62700PB1051941229 |e 60000PB1051941229 |k 0/60000/ |k 1/60000/62700/ |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1947770268 |e 4838998821 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Bunse, Lukas","role":"aut","family":"Bunse","given":"Lukas"},{"given":"Theresa","family":"Bunse","role":"aut","display":"Bunse, Theresa"},{"given":"Michael","role":"aut","family":"Kilian","display":"Kilian, Michael"},{"given":"Francisco J.","display":"Quintana, Francisco J.","family":"Quintana","role":"aut"},{"given":"Michael","role":"aut","family":"Platten","display":"Platten, Michael"}],"note":["Gesehen am 05.01.2026"],"language":["eng"],"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"3 Oct 2025"}],"name":{"displayForm":["Lukas Bunse, Theresa Bunse, Michael Kilian, Francisco J. Quintana, and Michael Platten"]},"id":{"doi":["10.1126/sciimmunol.ads0449"],"eki":["1947770268"]},"recId":"1947770268","type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"The immunology of brain tumors","subtitle":"cancer immunology","title_sort":"immunology of brain tumors"}],"relHost":[{"note":["Gesehen am 13. September 2021"],"pubHistory":["Volume 1, issue 1 (July 2016)-"],"language":["eng"],"disp":"The immunology of brain tumors cancer immunologyScience immunology","name":{"displayForm":["American Association for the Advancement of Science"]},"origin":[{"publisher":"AAAS","dateIssuedDisp":"[2016]-","publisherPlace":"Washington, DC"}],"id":{"zdb":["2862556-0"],"eki":["863416853"],"issn":["2470-9468"]},"recId":"863416853","type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Science immunology","title":"Science immunology"}],"part":{"year":"2025","text":"10(2025), 112, Artikel-ID eads0449, Seite ?","pages":"?","volume":"10","issue":"112"}}]} | ||
| SRT | |a BUNSELUKASIMMUNOLOGY3202 | ||