The relevance of right ventricular function and dimension in patients undergoing transcatheter tricuspid edge-to-edge repair
Background - Patients with severe tricuspid regurgitation (TR) often present with abnormal right ventricular (RV) function and dimensions. - Objectives - The aim of this study was to investigate the impact of RV dysfunction and dilation on clinical outcomes in patients undergoing transcatheter tricu...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2025 July 28
|
| In: |
JACC Cardiovascular interventions
Year: 2025, Volume: 18, Issue: 14, Pages: 1737-1745 |
| ISSN: | 1876-7605 |
| DOI: | 10.1016/j.jcin.2025.05.037 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jcin.2025.05.037 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1936879825016358 
|
| Author Notes: | Stephanie Brunner, MD, Lukas Stolz, MD, Karl-Patrik Kresoja, MD, Jennifer von Stein, MD, Vera Fortmeier, MD, Benedikt Koell, MD, Wolfgang Rottbauer, MD, Mohammad Kassar, MD, Bjoern Goebel, MD, Paolo Denti, MD, Paul Achouh, MD, Tienush Rassaf, MD, Manuel Barreiro-Perez, MD, Peter Boekstegers, MD, Andreas Rück, MD, Monika Zdanyte, MD, Flavien Vincent, MD, PhD, Philipp Schlegel, MD, Ralph Stephan von Bardeleben, MD, Mirjam G. Wild, MD, Christian Besler, MD, Matteo Pagnesi, MD, PhD, Marianna Adamo, MD, PhD, Julia Grapsa, MD, Tiffany Patterson, MD, Holger Thiele, MD, Tobias Kister, MD, Giuseppe Tarantini, MD, PhD, Giulia Masiero, MD, Marco De Carlo, MD, Alessandro Sticchi, MD, Mathias H. Konstandin, MD, Eric Van Belle, MD, PhD, Tobias Geisler, MD, Rodrigo Estévez-Loureiro, MD, Peter Luedike, MD, Nicole Karam, MD, Francesco Maisano, MD, Philipp Lauten, MD, Fabien Praz, MD, Mirjam Kessler, MD, Daniel Kalbacher, MD, Volker Rudolph, MD, Christos Iliadis, MD, Philipp Lurz, MD, Marco Metra, MD, Jörg Hausleiter, MD, Stefan Toggweiler, MD, the EuroTR Investigators |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1948094363 | ||
| 003 | DE-627 | ||
| 005 | 20260108174725.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260108s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jcin.2025.05.037 |2 doi | |
| 035 | |a (DE-627)1948094363 | ||
| 035 | |a (DE-599)KXP1948094363 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Brunner, Stephanie |e VerfasserIn |0 (DE-588)138621180X |0 (DE-627)1948094444 |4 aut | |
| 245 | 1 | 4 | |a The relevance of right ventricular function and dimension in patients undergoing transcatheter tricuspid edge-to-edge repair |c Stephanie Brunner, MD, Lukas Stolz, MD, Karl-Patrik Kresoja, MD, Jennifer von Stein, MD, Vera Fortmeier, MD, Benedikt Koell, MD, Wolfgang Rottbauer, MD, Mohammad Kassar, MD, Bjoern Goebel, MD, Paolo Denti, MD, Paul Achouh, MD, Tienush Rassaf, MD, Manuel Barreiro-Perez, MD, Peter Boekstegers, MD, Andreas Rück, MD, Monika Zdanyte, MD, Flavien Vincent, MD, PhD, Philipp Schlegel, MD, Ralph Stephan von Bardeleben, MD, Mirjam G. Wild, MD, Christian Besler, MD, Matteo Pagnesi, MD, PhD, Marianna Adamo, MD, PhD, Julia Grapsa, MD, Tiffany Patterson, MD, Holger Thiele, MD, Tobias Kister, MD, Giuseppe Tarantini, MD, PhD, Giulia Masiero, MD, Marco De Carlo, MD, Alessandro Sticchi, MD, Mathias H. Konstandin, MD, Eric Van Belle, MD, PhD, Tobias Geisler, MD, Rodrigo Estévez-Loureiro, MD, Peter Luedike, MD, Nicole Karam, MD, Francesco Maisano, MD, Philipp Lauten, MD, Fabien Praz, MD, Mirjam Kessler, MD, Daniel Kalbacher, MD, Volker Rudolph, MD, Christos Iliadis, MD, Philipp Lurz, MD, Marco Metra, MD, Jörg Hausleiter, MD, Stefan Toggweiler, MD, the EuroTR Investigators |
| 264 | 1 | |c 2025 July 28 | |
| 300 | |b Illustrationen | ||
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.01.2026 | ||
| 520 | |a Background - Patients with severe tricuspid regurgitation (TR) often present with abnormal right ventricular (RV) function and dimensions. - Objectives - The aim of this study was to investigate the impact of RV dysfunction and dilation on clinical outcomes in patients undergoing transcatheter tricuspid edge-to-edge repair (T-TEER). - Methods - Patients from the international EuroTR registry undergoing T-TEER between 2016 and 2023 at 20 heart valve centers across Europe were included. RV dysfunction was defined as tricuspid annular plane systolic excursion <17 mm, and RV dilation was defined as RV mid-diameter >35 mm, determined on baseline echocardiography. - Results - A total of 2,191 patients (mean age 78 ± 7 years, 53% [1,111 of 2,092] women) were analyzed. TR was successfully reduced to a severity grade of ≤2+ in 80% of patients (1,608 of 2,001). In multivariable analysis, significant predictors of mortality after T-TEER included RV dysfunction (HR: 1.05 per 1-mm tricuspid annular plane systolic excursion decrease; 95% CI: 1.03-1.08), RV dilation (HR: 1.02 per 1-mm RV mid-diameter increase; 95% CI: 1.00-1.03), and residual TR after T-TEER (HR: 1.70 for TR grade ≤2; 95% CI: 1.36-2.13). These parameters were also predictive of the combined endpoint of mortality and heart failure hospitalization. The worst prognosis was observed in patients exhibiting both RV dysfunction and dilation. - Conclusions - RV size and function, along with residual TR severity, were significant predictors of clinical outcomes, including all-cause mortality and heart failure hospitalization. Accordingly, early intervention to prevent RV dilation and dysfunction, as well as achieving maximal TR reduction, appears crucial for improving prognosis in patients undergoing T-TEER. | ||
| 650 | 4 | |a dilation | |
| 650 | 4 | |a dysfunction | |
| 650 | 4 | |a right ventricle | |
| 650 | 4 | |a transcatheter | |
| 650 | 4 | |a tricuspid regurgitation | |
| 700 | 1 | |a Stolz, Lukas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kresoja, Karl-Patrik |e VerfasserIn |4 aut | |
| 700 | 1 | |a von Stein, Jennifer |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fortmeier, Vera |e VerfasserIn |4 aut | |
| 700 | 1 | |a Koell, Benedikt |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rottbauer, Wolfgang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kassar, Mohammad |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goebel, Bjoern |e VerfasserIn |4 aut | |
| 700 | 1 | |a Denti, Paolo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Achouh, Paul |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rassaf, Tienush |e VerfasserIn |4 aut | |
| 700 | 1 | |a Barreiro-Perez, Manuel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Boekstegers, Peter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rück, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zdanyte, Monika |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vincent, Flavien |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schlegel, Philipp |d 1984- |e VerfasserIn |0 (DE-588)1043833781 |0 (DE-627)77097550X |0 (DE-576)395950260 |4 aut | |
| 700 | 1 | |a von Bardeleben, Ralph Stephan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wild, Mirjam G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Besler, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pagnesi, Matteo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Adamo, Marianna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grapsa, Julia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Patterson, Tiffany |e VerfasserIn |4 aut | |
| 700 | 1 | |a Thiele, Holger |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kister, Tobias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tarantini, Giuseppe |e VerfasserIn |4 aut | |
| 700 | 1 | |a Masiero, Giulia |e VerfasserIn |4 aut | |
| 700 | 1 | |a De Carlo, Marco |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sticchi, Alessandro |e VerfasserIn |4 aut | |
| 700 | 1 | |a Konstandin, Mathias |d 1976- |e VerfasserIn |0 (DE-588)12390708X |0 (DE-627)706469240 |0 (DE-576)29393701X |4 aut | |
| 700 | 1 | |a Van Belle, Eric |e VerfasserIn |4 aut | |
| 700 | 1 | |a Geisler, Tobias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Estévez-Loureiro, Rodrigo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Luedike, Peter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Karam, Nicole |e VerfasserIn |4 aut | |
| 700 | 1 | |a Maisano, Francesco |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lauten, Philipp |e VerfasserIn |4 aut | |
| 700 | 1 | |a Praz, Fabien |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kessler, Mirjam |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kalbacher, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rudolph, Volker |e VerfasserIn |4 aut | |
| 700 | 1 | |a Iliadis, Christos |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lurz, Philipp |e VerfasserIn |4 aut | |
| 700 | 1 | |a Metra, Marco |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hausleiter, Jörg |e VerfasserIn |4 aut | |
| 700 | 1 | |a Toggweiler, Stefan |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a American College of Cardiology |t JACC Cardiovascular interventions |d New York, NY : Elsevier, 2008 |g 18(2025), 14, Seite 1737-1745 |h Online-Ressource |w (DE-627)578539160 |w (DE-600)2452163-2 |w (DE-576)294403027 |x 1876-7605 |7 nnas |
| 773 | 1 | 8 | |g volume:18 |g year:2025 |g number:14 |g pages:1737-1745 |g extent:9 |a The relevance of right ventricular function and dimension in patients undergoing transcatheter tricuspid edge-to-edge repair |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jcin.2025.05.037 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |7 1 |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1936879825016358 |x Verlag |z lizenzpflichtig |3 Volltext |7 1 |
| 951 | |a AR | ||
| 992 | |a 20260108 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 12390708X |a Konstandin, Mathias |m 12390708X:Konstandin, Mathias |d 910000 |d 910100 |e 910000PK12390708X |e 910100PK12390708X |k 0/910000/ |k 1/910000/910100/ | ||
| 998 | |g 1043833781 |a Schlegel, Philipp |m 1043833781:Schlegel, Philipp |d 910000 |d 910100 |e 910000PS1043833781 |e 910100PS1043833781 |k 0/910000/ |k 1/910000/910100/ |p 18 | ||
| 999 | |a KXP-PPN1948094363 |e 4842063114 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"name":{"displayForm":["Stephanie Brunner, MD, Lukas Stolz, MD, Karl-Patrik Kresoja, MD, Jennifer von Stein, MD, Vera Fortmeier, MD, Benedikt Koell, MD, Wolfgang Rottbauer, MD, Mohammad Kassar, MD, Bjoern Goebel, MD, Paolo Denti, MD, Paul Achouh, MD, Tienush Rassaf, MD, Manuel Barreiro-Perez, MD, Peter Boekstegers, MD, Andreas Rück, MD, Monika Zdanyte, MD, Flavien Vincent, MD, PhD, Philipp Schlegel, MD, Ralph Stephan von Bardeleben, MD, Mirjam G. Wild, MD, Christian Besler, MD, Matteo Pagnesi, MD, PhD, Marianna Adamo, MD, PhD, Julia Grapsa, MD, Tiffany Patterson, MD, Holger Thiele, MD, Tobias Kister, MD, Giuseppe Tarantini, MD, PhD, Giulia Masiero, MD, Marco De Carlo, MD, Alessandro Sticchi, MD, Mathias H. Konstandin, MD, Eric Van Belle, MD, PhD, Tobias Geisler, MD, Rodrigo Estévez-Loureiro, MD, Peter Luedike, MD, Nicole Karam, MD, Francesco Maisano, MD, Philipp Lauten, MD, Fabien Praz, MD, Mirjam Kessler, MD, Daniel Kalbacher, MD, Volker Rudolph, MD, Christos Iliadis, MD, Philipp Lurz, MD, Marco Metra, MD, Jörg Hausleiter, MD, Stefan Toggweiler, MD, the EuroTR Investigators"]},"person":[{"given":"Stephanie","display":"Brunner, Stephanie","role":"aut","family":"Brunner"},{"display":"Stolz, Lukas","given":"Lukas","role":"aut","family":"Stolz"},{"given":"Karl-Patrik","display":"Kresoja, Karl-Patrik","role":"aut","family":"Kresoja"},{"given":"Jennifer","display":"von Stein, Jennifer","role":"aut","family":"von Stein"},{"given":"Vera","display":"Fortmeier, Vera","family":"Fortmeier","role":"aut"},{"role":"aut","family":"Koell","given":"Benedikt","display":"Koell, Benedikt"},{"role":"aut","family":"Rottbauer","display":"Rottbauer, Wolfgang","given":"Wolfgang"},{"family":"Kassar","role":"aut","given":"Mohammad","display":"Kassar, Mohammad"},{"given":"Bjoern","display":"Goebel, Bjoern","family":"Goebel","role":"aut"},{"given":"Paolo","display":"Denti, Paolo","family":"Denti","role":"aut"},{"family":"Achouh","role":"aut","given":"Paul","display":"Achouh, Paul"},{"given":"Tienush","display":"Rassaf, Tienush","family":"Rassaf","role":"aut"},{"family":"Barreiro-Perez","role":"aut","given":"Manuel","display":"Barreiro-Perez, Manuel"},{"given":"Peter","display":"Boekstegers, Peter","role":"aut","family":"Boekstegers"},{"given":"Andreas","display":"Rück, Andreas","family":"Rück","role":"aut"},{"display":"Zdanyte, Monika","given":"Monika","family":"Zdanyte","role":"aut"},{"family":"Vincent","role":"aut","display":"Vincent, Flavien","given":"Flavien"},{"role":"aut","family":"Schlegel","display":"Schlegel, Philipp","given":"Philipp"},{"family":"von Bardeleben","role":"aut","display":"von Bardeleben, Ralph Stephan","given":"Ralph Stephan"},{"given":"Mirjam G.","display":"Wild, Mirjam G.","family":"Wild","role":"aut"},{"family":"Besler","role":"aut","display":"Besler, Christian","given":"Christian"},{"given":"Matteo","display":"Pagnesi, Matteo","family":"Pagnesi","role":"aut"},{"given":"Marianna","display":"Adamo, Marianna","family":"Adamo","role":"aut"},{"display":"Grapsa, Julia","given":"Julia","role":"aut","family":"Grapsa"},{"role":"aut","family":"Patterson","given":"Tiffany","display":"Patterson, Tiffany"},{"role":"aut","family":"Thiele","display":"Thiele, Holger","given":"Holger"},{"family":"Kister","role":"aut","given":"Tobias","display":"Kister, Tobias"},{"given":"Giuseppe","display":"Tarantini, Giuseppe","family":"Tarantini","role":"aut"},{"given":"Giulia","display":"Masiero, Giulia","role":"aut","family":"Masiero"},{"family":"De Carlo","role":"aut","display":"De Carlo, Marco","given":"Marco"},{"given":"Alessandro","display":"Sticchi, Alessandro","family":"Sticchi","role":"aut"},{"display":"Konstandin, Mathias","given":"Mathias","role":"aut","family":"Konstandin"},{"family":"Van Belle","role":"aut","display":"Van Belle, Eric","given":"Eric"},{"given":"Tobias","display":"Geisler, Tobias","family":"Geisler","role":"aut"},{"given":"Rodrigo","display":"Estévez-Loureiro, Rodrigo","family":"Estévez-Loureiro","role":"aut"},{"role":"aut","family":"Luedike","display":"Luedike, Peter","given":"Peter"},{"role":"aut","family":"Karam","given":"Nicole","display":"Karam, Nicole"},{"role":"aut","family":"Maisano","display":"Maisano, Francesco","given":"Francesco"},{"display":"Lauten, Philipp","given":"Philipp","family":"Lauten","role":"aut"},{"given":"Fabien","display":"Praz, Fabien","role":"aut","family":"Praz"},{"family":"Kessler","role":"aut","given":"Mirjam","display":"Kessler, Mirjam"},{"display":"Kalbacher, Daniel","given":"Daniel","role":"aut","family":"Kalbacher"},{"display":"Rudolph, Volker","given":"Volker","role":"aut","family":"Rudolph"},{"given":"Christos","display":"Iliadis, Christos","family":"Iliadis","role":"aut"},{"family":"Lurz","role":"aut","display":"Lurz, Philipp","given":"Philipp"},{"role":"aut","family":"Metra","display":"Metra, Marco","given":"Marco"},{"family":"Hausleiter","role":"aut","given":"Jörg","display":"Hausleiter, Jörg"},{"role":"aut","family":"Toggweiler","display":"Toggweiler, Stefan","given":"Stefan"}],"recId":"1948094363","note":["Gesehen am 08.01.2026"],"title":[{"title_sort":"relevance of right ventricular function and dimension in patients undergoing transcatheter tricuspid edge-to-edge repair","title":"The relevance of right ventricular function and dimension in patients undergoing transcatheter tricuspid edge-to-edge repair"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1016/j.jcin.2025.05.037"],"eki":["1948094363"]},"physDesc":[{"noteIll":"Illustrationen","extent":"9 S."}],"relHost":[{"recId":"578539160","physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2452163-2"],"issn":["1876-7605"],"eki":["578539160"]},"title":[{"title_sort":"JACC Cardiovascular interventions","subtitle":"a journal of the American College of Cardiology","title":"JACC Cardiovascular interventions"}],"origin":[{"publisherPlace":"New York, NY ; New York, NY","dateIssuedKey":"2008","dateIssuedDisp":"2008-","publisher":"Elsevier ; American College of Cardiology"}],"part":{"year":"2025","volume":"18","text":"18(2025), 14, Seite 1737-1745","issue":"14","extent":"9","pages":"1737-1745"},"language":["eng"],"note":["Gesehen am 05.06.23","Fortsetzung der Druck-Ausgabe"],"pubHistory":["1.2008 -"],"disp":"American College of CardiologyJACC Cardiovascular interventions","type":{"bibl":"periodical","media":"Online-Ressource"},"corporate":[{"display":"American College of Cardiology","role":"aut"}]}],"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"2025 July 28"}]} | ||
| SRT | |a BRUNNERSTERELEVANCEO2025 | ||