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Cohort profile of the Heidelberg study on diabetes and complications HEIST-DiC

The Heidelberg Study on Diabetes and Complications (HEIST-DiC) is a prospective longitudinal study focused on the development and progression of diabetes-associated complications. Participants with/without diabetes mellitus undergo annual phenotyping of diabetes-associated complications over 11 year...

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Main Authors: Kliemank, Elisabeth (Author) , Rauchhaupt, Ekaterina von (Author) , Seebauer, Lukas (Author) , Roshan, Mani (Author) , Ansmann, Malin (Author) , Flegka, Viktoria (Author) , Schimpfle, Lukas (Author) , Tsilingiris, Dimitrios (Author) , Bartl, Hannelore (Author) , Fleming, Thomas (Author) , Kender, Zoltán (Author) , Jende, Johann (Author) , Mooshage, Christoph (Author) , Schwarz, Daniel (Author) , Bendszus, Martin (Author) , Schirmacher, Peter (Author) , Herzig, Stephan (Author) , Nawroth, Peter Paul (Author) , Kopf, Stefan (Author) , Szendrödi, Julia (Author) , Sulaj, Alba (Author)
Format: Article (Journal)
Language:English
Published: 2025
In: Scientific reports
Year: 2025, Volume: 15
ISSN:2045-2322
DOI:10.1038/s41598-025-15343-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-025-15343-8
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-025-15343-8
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Author Notes:Elisabeth Kliemank, Ekaterina von Rauchhaupt, Lukas Seebauer, Mani Roshan, Malin Ansmann, Viktoria Flegka, Lukas Schimpfle, Dimitrios Tsilingiris, Hannelore Bartl, Thomas Fleming, Zoltan Kender, Johann M. E. Jende, Christoph M. Mooshage, Daniel Schwarz, Martin Bendszus, Peter Schirmacher, Stephan Herzig, Peter P. Nawroth, Stefan Kopf, Julia Szendroedi & Alba Sulaj
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Summary:The Heidelberg Study on Diabetes and Complications (HEIST-DiC) is a prospective longitudinal study focused on the development and progression of diabetes-associated complications. Participants with/without diabetes mellitus undergo annual phenotyping of diabetes-associated complications over 11 years. Assessments include: albuminuria, estimated glomerular filtration rate for chronic kidney disease; clinical neuropathy scores, Purdue Pegboard test, electrophysiological examination, transcutaneous electrical nerve fiber stimulation, quantitative sensory testing and high-resolution magnetic resonance neurography for distal sensorimotor polyneuropathy; heart rate variability for cardiovascular autonomic neuropathy; funduscopic examination of undilated pupils for retinopathy; the 6-minute walk test, spirometry, body plethysmography, and carbon monoxide-based diffusing capacity measurements for respiratory lung disease; non-invasive scores, transient elastography and hepatic ultrasound for metabolic dysfunction-associated steatotic liver disease; ankle-brachial index and carotid intima-media thickness for peripheral atherosclerosis; hand grip strength for muscle function; bioelectrical impedance analysis for body composition; skin autofluorescence for measurement of advanced glycation end products. Beta-cell function and tissue-specific insulin sensitivity are evaluated using oral glucose tolerance test or euglycemic hyperinsulinemic clamp. The biobank stores specimens of blood, urine, skeletal muscle, subcutaneous adipose tissue, and skin. Health-related quality of life, physical health, and somatic and depression symptoms are measured via standardized questionnaires. HEIST-DiC explores diabetes onset in high-risk individuals, disease progression and the development of complications, aiming to design personalized strategies to prevent, mitigate, or reverse diabetes-related complications.
Item Description:Online veröffentlicht: 12. August 2025
Gesehen am 09.01.2026
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-025-15343-8

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