Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer
Wnt signaling pathways are involved in various developmental and tissue maintenance functions, whereas deregulated Wnt signaling is closely linked to human cancer. Recent work revealed that loss of Wnt signaling impairs mitosis and causes abnormal microtubule growth at the mitotic spindle resulting...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 2025
|
| In: |
Life science alliance
Year: 2025, Jahrgang: 8, Heft: 11, Pages: 1-15 |
| ISSN: | 2575-1077 |
| DOI: | 10.26508/lsa.202503295 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.26508/lsa.202503295 Verlag, lizenzpflichtig, Volltext: https://www.life-science-alliance.org/content/8/11/e202503295 
|
| Verfasserangaben: | Alexander Haas, Friederike Wenz, Janina Hattemer, Janine Wesslowski, Gary Davidson, Oksana Voloshanenko, Michael Boutros, Sergio P. Acebron, Holger Bastians |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1948410737 | ||
| 003 | DE-627 | ||
| 005 | 20260112072945.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260112s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.26508/lsa.202503295 |2 doi | |
| 035 | |a (DE-627)1948410737 | ||
| 035 | |a (DE-599)KXP1948410737 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Haas, Alexander |e VerfasserIn |0 (DE-588)1386446513 |0 (DE-627)1948410974 |4 aut | |
| 245 | 1 | 0 | |a Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer |c Alexander Haas, Friederike Wenz, Janina Hattemer, Janine Wesslowski, Gary Davidson, Oksana Voloshanenko, Michael Boutros, Sergio P. Acebron, Holger Bastians |
| 264 | 1 | |c November 2025 | |
| 300 | |b Illustrationen, Diagramme | ||
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 22 August 2025 | ||
| 500 | |a Gesehen am 12.01.2026 | ||
| 520 | |a Wnt signaling pathways are involved in various developmental and tissue maintenance functions, whereas deregulated Wnt signaling is closely linked to human cancer. Recent work revealed that loss of Wnt signaling impairs mitosis and causes abnormal microtubule growth at the mitotic spindle resulting in chromosome missegregation and aneuploidy, both of which are hallmarks of cancer cells exhibiting chromosomal instability (CIN). Here, we show that upon DNA replication stress, a condition typically associated with CIN, Wnt10b acts to prevent increased microtubule dynamics from the S phase until mitosis, thereby ensuring faithful chromosome segregation. Interestingly, replication stress-induced chromosomal breaks are also efficiently suppressed by Wnt10b. Thus, our results show that Wnt10b signaling regulates replication stress-induced chromosome missegregation and breakage, and hence is a determinant for broad genome instability in cancer cells. | ||
| 700 | 1 | |a Wenz, Friederike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hattemer, Janina |e VerfasserIn |0 (DE-588)1354689852 |0 (DE-627)1915861535 |4 aut | |
| 700 | 1 | |a Wesslowski, Janine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Davidson, Gary |e VerfasserIn |4 aut | |
| 700 | 1 | |a Voloshanenko, Oksana |d 1981- |e VerfasserIn |0 (DE-588)143206419 |0 (DE-627)704420589 |0 (DE-576)33563415X |4 aut | |
| 700 | 1 | |a Boutros, Michael |e VerfasserIn |0 (DE-588)1023031132 |0 (DE-627)717350045 |0 (DE-576)366291831 |4 aut | |
| 700 | 1 | |a Acebron, Sergio P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bastians, Holger |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Life science alliance |d Heidelberg : EMBO Press, 2018 |g 8(2025), 11 vom: Nov., Seite 1-15 |h Online-Ressource |w (DE-627)1040376843 |w (DE-600)2948687-7 |w (DE-576)513597522 |x 2575-1077 |7 nnas |a Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer |
| 773 | 1 | 8 | |g volume:8 |g year:2025 |g number:11 |g month:11 |g pages:1-15 |g extent:15 |a Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer |
| 856 | 4 | 0 | |u https://doi.org/10.26508/lsa.202503295 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |7 1 |
| 856 | 4 | 0 | |u https://www.life-science-alliance.org/content/8/11/e202503295 |x Verlag |z lizenzpflichtig |3 Volltext |7 1 |
| 951 | |a AR | ||
| 992 | |a 20260112 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1023031132 |a Boutros, Michael |m 1023031132:Boutros, Michael |d 910000 |d 911500 |d 60000 |e 910000PB1023031132 |e 911500PB1023031132 |e 60000PB1023031132 |k 0/910000/ |k 1/910000/911500/ |k 0/60000/ |p 7 | ||
| 998 | |g 143206419 |a Voloshanenko, Oksana |m 143206419:Voloshanenko, Oksana |d 910000 |d 911500 |e 910000PV143206419 |e 911500PV143206419 |k 0/910000/ |k 1/910000/911500/ |p 6 | ||
| 998 | |g 1354689852 |a Hattemer, Janina |m 1354689852:Hattemer, Janina |d 700000 |d 721000 |d 140000 |e 700000PH1354689852 |e 721000PH1354689852 |e 140000PH1354689852 |k 0/700000/ |k 1/700000/721000/ |k 0/140000/ |p 3 | ||
| 999 | |a KXP-PPN1948410737 |e 484474688X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"15 S.","noteIll":"Illustrationen, Diagramme"}],"id":{"doi":["10.26508/lsa.202503295"],"eki":["1948410737"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Online veröffentlicht: 22 August 2025","Gesehen am 12.01.2026"],"relHost":[{"id":{"eki":["1040376843"],"issn":["2575-1077"],"zdb":["2948687-7"]},"pubHistory":["Volume 1, no. 1 (January 2018)-"],"part":{"extent":"15","issue":"11","year":"2025","pages":"1-15","text":"8(2025), 11 vom: Nov., Seite 1-15","volume":"8"},"type":{"media":"Online-Ressource","bibl":"periodical"},"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Heidelberg","publisher":"EMBO Press","dateIssuedDisp":"[2018]-"}],"disp":"Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancerLife science alliance","recId":"1040376843","title":[{"title_sort":"Life science alliance","title":"Life science alliance"}],"language":["eng"]}],"person":[{"display":"Haas, Alexander","given":"Alexander","family":"Haas","role":"aut"},{"given":"Friederike","display":"Wenz, Friederike","family":"Wenz","role":"aut"},{"role":"aut","family":"Hattemer","display":"Hattemer, Janina","given":"Janina"},{"role":"aut","display":"Wesslowski, Janine","given":"Janine","family":"Wesslowski"},{"role":"aut","family":"Davidson","given":"Gary","display":"Davidson, Gary"},{"role":"aut","family":"Voloshanenko","given":"Oksana","display":"Voloshanenko, Oksana"},{"role":"aut","display":"Boutros, Michael","given":"Michael","family":"Boutros"},{"role":"aut","given":"Sergio P.","display":"Acebron, Sergio P.","family":"Acebron"},{"role":"aut","family":"Bastians","display":"Bastians, Holger","given":"Holger"}],"name":{"displayForm":["Alexander Haas, Friederike Wenz, Janina Hattemer, Janine Wesslowski, Gary Davidson, Oksana Voloshanenko, Michael Boutros, Sergio P. Acebron, Holger Bastians"]},"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"November 2025"}],"recId":"1948410737","title":[{"title":"Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer","title_sort":"Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer"}],"language":["eng"]} | ||
| SRT | |a HAASALEXANWNT10BSIGN2025 | ||