Virus-associated inflammation imprints an inflammatory profile on monocyte-derived macrophages in the human liver
Chronic liver injury triggers the activation and recruitment of immune cells, causing antigen-independent tissue damage and liver disease progression. Tissue inflammation can reshape macrophage composition through monocyte replacement. Replacement of tissue macrophages with monocytes differentiating...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 15, 2025
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| In: |
The journal of clinical investigation
Year: 2025, Jahrgang: 135, Heft: 8, Pages: 1-14 |
| ISSN: | 1558-8238 |
| DOI: | 10.1172/JCI175241 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1172/JCI175241 Verlag, kostenfrei, Volltext: https://www.jci.org/articles/view/175241#SEC5 
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| Verfasserangaben: | Juan Diego Sanchez Vasquez, Shirin Nkongolo, Daniel Traum, Valentin Sotov, Samuel C. Kim, Deeqa Mahamed, Aman Mehrotra, Anjali Patel, Diana Y. Chen, Scott Fung, Anuj Gaggar, Jordan J. Feld, Kyong-Mi Chang, Jeffrey J. Wallin, Ben X. Wang, Harry L.A. Janssen, and Adam J. Gehring |
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| 245 | 1 | 0 | |a Virus-associated inflammation imprints an inflammatory profile on monocyte-derived macrophages in the human liver |c Juan Diego Sanchez Vasquez, Shirin Nkongolo, Daniel Traum, Valentin Sotov, Samuel C. Kim, Deeqa Mahamed, Aman Mehrotra, Anjali Patel, Diana Y. Chen, Scott Fung, Anuj Gaggar, Jordan J. Feld, Kyong-Mi Chang, Jeffrey J. Wallin, Ben X. Wang, Harry L.A. Janssen, and Adam J. Gehring |
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| 520 | |a Chronic liver injury triggers the activation and recruitment of immune cells, causing antigen-independent tissue damage and liver disease progression. Tissue inflammation can reshape macrophage composition through monocyte replacement. Replacement of tissue macrophages with monocytes differentiating in an inflammatory environment can potentially imprint a phenotype that switches the liver from an immune-tolerant organ to one predisposed to tissue damage. We longitudinally sampled the liver of patients with chronic hepatitis B who had active liver inflammation and were starting antiviral therapy. Antiviral therapy suppressed viral replication and liver inflammation, which coincided with decreased myeloid activation markers. Single-cell RNA-Seq mapped peripheral inflammatory markers to a monocyte-derived macrophage population, distinct from Kupffer cells, with an inflammatory transcriptional profile. The inflammatory macrophages (iMacs) differentiated from blood monocytes and were unique from macrophage found in healthy or cirrhotic liver. iMacs retained their core transcriptional signature after inflammation resolved, indicating inflammation-mediated remodeling of the macrophage population in the human liver that may affect progressive liver disease and immunotherapy. | ||
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| 700 | 1 | |a Traum, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sotov, Valentin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kim, Samuel C. |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Janssen, Harry L. A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gehring, Adam J. |e VerfasserIn |4 aut | |
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