Circulating inflammation-related proteome improves cardiovascular risk prediction. Results from two large European cohort studies
Background: Inflammation plays a crucial role in cardiovascular disease (CVD), but the value of inflammation-related proteins in predicting major adverse cardiovascular events (MACE) is unclear. This study evaluated whether incorporating inflammation-related proteins into the SCORE2 model improves 1...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 August 2025
|
| In: |
European journal of epidemiology
Year: 2025, Jahrgang: 40, Heft: 10, Pages: 1191-1203 |
| ISSN: | 1573-7284 |
| DOI: | 10.1007/s10654-025-01285-y |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s10654-025-01285-y
|
| Verfasserangaben: | Ruijie Xie, Sha Sha, Hermann Brenner, Ben Schöttker |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1948432854 | ||
| 003 | DE-627 | ||
| 005 | 20260112095914.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260112s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10654-025-01285-y |2 doi | |
| 035 | |a (DE-627)1948432854 | ||
| 035 | |a (DE-599)KXP1948432854 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Xie, Ruijie |e VerfasserIn |0 (DE-588)1309114528 |0 (DE-627)1869712021 |4 aut | |
| 245 | 1 | 0 | |a Circulating inflammation-related proteome improves cardiovascular risk prediction. Results from two large European cohort studies |c Ruijie Xie, Sha Sha, Hermann Brenner, Ben Schöttker |
| 264 | 1 | |c 13 August 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 13. August 2025 | ||
| 500 | |a Gesehen am 12.01.2026 | ||
| 520 | |a Background: Inflammation plays a crucial role in cardiovascular disease (CVD), but the value of inflammation-related proteins in predicting major adverse cardiovascular events (MACE) is unclear. This study evaluated whether incorporating inflammation-related proteins into the SCORE2 model improves 10-year MACE risk prediction. Methods: This study included 47,382 participants from the UK Biobank and 4,135 participants from the German ESTHER study without prior CVD or diabetes. We tested C-reactive protein (CRP) and 73 inflammation-related proteins measured with Olink® panels. Biomarker selection was performed using least absolute shrinkage and selection operator (LASSO) regression with bootstrapping separately for males and females. Selected proteins were added to the SCORE2 model variables. Model performance was evaluated using Harrell’s C-index, net reclassification index (NRI), and integrated discrimination index (IDI). Results: Seven inflammation-related proteins but not CRP were selected, including two for both sexes, three specifically for males, and two specifically for females. Incorporating these proteins significantly improved the C-index (95% confidence interval (95%CI)) of the refitted SCORE2 model from 0.716 (0.698, 0.734) to 0.750 (0.732, 0.768) in internal validation in the UK Biobank and from 0.677 (0.644, 0.710) to 0.713 (0.681, 0.745) in external validation in the ESTHER study. The NRI with 95%CI was 12.4% (5.2%, 16.3%) in internal validation and 4.2% (0.5%, 23.6%) in external validation. The IDI also improved significantly. Conclusion: Incorporating inflammation-related proteins into the SCORE2 model significantly improves the prediction of 10-year MACE risk among individuals without prior CVD or diabetes. Measuring these proteins may enhance risk stratification in clinical practice. | ||
| 650 | 4 | |a Cardiovascular disease | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Proteins | |
| 650 | 4 | |a Proteomics | |
| 650 | 4 | |a Risk prediction | |
| 700 | 1 | |a Sha, Sha |e VerfasserIn |0 (DE-588)1309119147 |0 (DE-627)1869717856 |4 aut | |
| 700 | 1 | |a Brenner, Hermann |e VerfasserIn |0 (DE-588)1020516445 |0 (DE-627)691247005 |0 (DE-576)360642136 |4 aut | |
| 700 | 1 | |a Schöttker, Ben |e VerfasserIn |0 (DE-588)138862443 |0 (DE-627)703132423 |0 (DE-576)309375657 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of epidemiology |d [Cham] : Springer Nature Switzerland AG, 1985 |g 40(2025), 10, Seite 1191-1203 |h Online-Ressource |w (DE-627)320441636 |w (DE-600)2004992-4 |w (DE-576)121465535 |x 1573-7284 |7 nnas |a Circulating inflammation-related proteome improves cardiovascular risk prediction. Results from two large European cohort studies |
| 773 | 1 | 8 | |g volume:40 |g year:2025 |g number:10 |g pages:1191-1203 |g extent:13 |a Circulating inflammation-related proteome improves cardiovascular risk prediction. Results from two large European cohort studies |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10654-025-01285-y |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20260112 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 138862443 |a Schöttker, Ben |m 138862443:Schöttker, Ben |d 50000 |e 50000PS138862443 |k 0/50000/ |p 4 |y j | ||
| 998 | |g 1020516445 |a Brenner, Hermann |m 1020516445:Brenner, Hermann |d 850000 |d 851600 |d 50000 |e 850000PB1020516445 |e 851600PB1020516445 |e 50000PB1020516445 |k 0/850000/ |k 1/850000/851600/ |k 0/50000/ |p 3 | ||
| 998 | |g 1309119147 |a Sha, Sha |m 1309119147:Sha, Sha |p 2 | ||
| 998 | |g 1309114528 |a Xie, Ruijie |m 1309114528:Xie, Ruijie |d 50000 |e 50000PX1309114528 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1948432854 |e 4844876074 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"13 August 2025"}],"person":[{"role":"aut","given":"Ruijie","family":"Xie","display":"Xie, Ruijie"},{"display":"Sha, Sha","role":"aut","given":"Sha","family":"Sha"},{"display":"Brenner, Hermann","given":"Hermann","role":"aut","family":"Brenner"},{"display":"Schöttker, Ben","given":"Ben","role":"aut","family":"Schöttker"}],"relHost":[{"disp":"Circulating inflammation-related proteome improves cardiovascular risk prediction. Results from two large European cohort studiesEuropean journal of epidemiology","physDesc":[{"extent":"Online-Ressource"}],"recId":"320441636","note":["Gesehen am 26.08.2020","Gesehen am 16.03.09"],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"title":[{"title":"European journal of epidemiology","title_sort":"European journal of epidemiology"}],"part":{"volume":"40","year":"2025","issue":"10","extent":"13","text":"40(2025), 10, Seite 1191-1203","pages":"1191-1203"},"id":{"zdb":["2004992-4"],"issn":["1573-7284"],"eki":["320441636"]},"pubHistory":["1.1985 -"],"origin":[{"dateIssuedDisp":"1985-","dateIssuedKey":"1985","publisherPlace":"[Cham] ; Dordrecht [u.a.] ; Dordrecht [u.a.] ; Dordrecht [u.a.]","publisher":"Springer Nature Switzerland AG ; Springer Science + Business Media B.V. ; Springer Science + Business Media B.V. ; Kluwer Acad. Publ."}]}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"note":["Online veröffentlicht: 13. August 2025","Gesehen am 12.01.2026"],"title":[{"title_sort":"Circulating inflammation-related proteome improves cardiovascular risk prediction. Results from two large European cohort studies","title":"Circulating inflammation-related proteome improves cardiovascular risk prediction. Results from two large European cohort studies"}],"physDesc":[{"extent":"13 S.","noteIll":"Illustrationen"}],"recId":"1948432854","name":{"displayForm":["Ruijie Xie, Sha Sha, Hermann Brenner, Ben Schöttker"]},"id":{"doi":["10.1007/s10654-025-01285-y"],"eki":["1948432854"]}} | ||
| SRT | |a XIERUIJIESCIRCULATIN1320 | ||