Buchumschlag

Elevated levels of Letm1 drives mitochondrial dysfunction and cardiomyocyte stress-mediated apoptosis in cultured cardiomyocytes

Cardiac ischemia, a predominant cause of heart failure, is marked by profound mitochondrial dysfunction, dysregulated ion homeostasis, and maladaptive cellular remodeling, all of which compromise cardiac performance. The mitochondrial inner membrane protein Leucine zipper-EF-hand containing Transmem...

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Hauptverfasser: Deshpande, Anushka (VerfasserIn) , Weirauch, Leo (VerfasserIn) , Baral, Tapan Kumar (VerfasserIn) , Steier, Marco (VerfasserIn) , Borlepawar, Ankush (VerfasserIn) , Kumari, Manju (VerfasserIn) , Kilian, Lucia S. (VerfasserIn) , Richter, Karsten (VerfasserIn) , Hammer, Elke (VerfasserIn) , Frank, Derk (VerfasserIn) , Schmidt, Constanze (VerfasserIn) , Frey, Norbert (VerfasserIn) , Rangrez, Ashraf Yusuf (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2025
In: Cell communication and signaling
Year: 2025, Jahrgang: 23, Pages: 1-24
ISSN:1478-811X
DOI:10.1186/s12964-025-02378-7
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12964-025-02378-7
Volltext
Verfasserangaben:Anushka Deshpande, Leo Weirauch, Tapan Kumar Baral, Marco Steier, Ankush Borlepawar, Manju Kumari, Lucia S. Kilian, Karsten Richter, Elke Hammer, Derk Frank, Constanze Schmidt, Norbert Frey and Ashraf Y. Rangrez
Beschreibung
Zusammenfassung:Cardiac ischemia, a predominant cause of heart failure, is marked by profound mitochondrial dysfunction, dysregulated ion homeostasis, and maladaptive cellular remodeling, all of which compromise cardiac performance. The mitochondrial inner membrane protein Leucine zipper-EF-hand containing Transmembrane Protein 1 (Letm1), implicated in Wolf-Hirschhorn Syndrome, is essential for mitochondrial function. Although genetic alterations in Letm1 are linked to cardiomyopathies, its specific contributions to cardiac pathophysiology, particularly in the context of ischemic heart disease, remain poorly defined. This study aims to elucidate the role of Letm1 in ischemic cardiac pathology and its mechanistic impact on cardiomyocyte function.
Beschreibung:Online veröffentlicht: 23. August 2025
Gesehen am 12.01.2026
Beschreibung:Online Resource
ISSN:1478-811X
DOI:10.1186/s12964-025-02378-7

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