(R)-Ketamine reduces alcohol intake and alcohol seeking induced by reconsolidation of alcohol-related memories in female Marchigian Sardinian alcohol-preferring rats
Alcohol use disorder (AUD) represents a significant medical challenge, with available therapeutic approaches having limited efficacy. Emerging data suggest that psychedelic compounds could represent an alternative treatment for AUD. Among this class of molecules, ketamine, a dissociative psychedelic...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 November 2025
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| In: |
Psychopharmacology
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| ISSN: | 1432-2072 |
| DOI: | 10.1007/s00213-025-06964-y |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00213-025-06964-y
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| Verfasserangaben: | Elisabetta Ciccocioppo, Sara Massetti, Marcus W. Meinhardt, Fabio Fumagalli, Patrizia Romualdi, Marisa Roberto, Rainer Spanagel, Roberto Ciccocioppo, Esi Domi |
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| 245 | 1 | 0 | |a (R)-Ketamine reduces alcohol intake and alcohol seeking induced by reconsolidation of alcohol-related memories in female Marchigian Sardinian alcohol-preferring rats |c Elisabetta Ciccocioppo, Sara Massetti, Marcus W. Meinhardt, Fabio Fumagalli, Patrizia Romualdi, Marisa Roberto, Rainer Spanagel, Roberto Ciccocioppo, Esi Domi |
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| 520 | |a Alcohol use disorder (AUD) represents a significant medical challenge, with available therapeutic approaches having limited efficacy. Emerging data suggest that psychedelic compounds could represent an alternative treatment for AUD. Among this class of molecules, ketamine, a dissociative psychedelic, shows promising properties. It reduces alcohol drinking in rodents and in humans it is used to treat depression, a condition often comorbid with AUD. Unfortunately, the marked dissociative and anesthetic effects of this molecule severely limit its therapeutic application. Ketamine is a racemic mixture of (S, R)-enantiomers, and the R-enantiomer possesses lower dissociative and anesthetic properties compared to the racemic mixture. | ||
| 650 | 4 | |a (R)-ketamine | |
| 650 | 4 | |a Alcohol use disorder (AUD) | |
| 650 | 4 | |a Memory retrieval | |
| 650 | 4 | |a Psychedelics | |
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