A cholesterol-dependent switch controls organ-specific metastasis in pancreatic cancer
As different organs offer distinct chemical microenvironments, cancer cells require unique metabolic adaptation to colonize distant sites. In a recent issue of Nature, Rademaker et al. identify PCSK9 as a predictive factor for metastatic colonization of different organs, showing adaptation of cancer...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
4 August 2025
|
| In: |
Developmental cell
Year: 2025, Volume: 60, Issue: 15, Pages: 2029-2031 |
| ISSN: | 1878-1551 |
| DOI: | 10.1016/j.devcel.2025.07.001 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.devcel.2025.07.001 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1534580725004393 
|
| Author Notes: | Julie Haenlin and Almut Schulze |
| Summary: | As different organs offer distinct chemical microenvironments, cancer cells require unique metabolic adaptation to colonize distant sites. In a recent issue of Nature, Rademaker et al. identify PCSK9 as a predictive factor for metastatic colonization of different organs, showing adaptation of cancer cells to different environments by regulating cholesterol metabolism. |
|---|---|
| Item Description: | Gesehen am 12.01.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1878-1551 |
| DOI: | 10.1016/j.devcel.2025.07.001 |