A cholesterol-dependent switch controls organ-specific metastasis in pancreatic cancer
As different organs offer distinct chemical microenvironments, cancer cells require unique metabolic adaptation to colonize distant sites. In a recent issue of Nature, Rademaker et al. identify PCSK9 as a predictive factor for metastatic colonization of different organs, showing adaptation of cancer...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
4 August 2025
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| In: |
Developmental cell
Year: 2025, Jahrgang: 60, Heft: 15, Pages: 2029-2031 |
| ISSN: | 1878-1551 |
| DOI: | 10.1016/j.devcel.2025.07.001 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.devcel.2025.07.001 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1534580725004393 
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| Verfasserangaben: | Julie Haenlin and Almut Schulze |
| Zusammenfassung: | As different organs offer distinct chemical microenvironments, cancer cells require unique metabolic adaptation to colonize distant sites. In a recent issue of Nature, Rademaker et al. identify PCSK9 as a predictive factor for metastatic colonization of different organs, showing adaptation of cancer cells to different environments by regulating cholesterol metabolism. |
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| Beschreibung: | Gesehen am 12.01.2026 |
| Beschreibung: | Online Resource |
| ISSN: | 1878-1551 |
| DOI: | 10.1016/j.devcel.2025.07.001 |