Gold-catalyzed highly regioselective cage B(9)-H alkylation of o-carboranes with 1,6-enynes
Described herein is a gold-catalyzed regioselective B(9)-H alkylation of o-carboranes via regioselective insertion of exo-cyclopropyl gold carbenes, generated in situ by gold-catalyzed 5-exo-dig cyclization of 1,6-enynes, into the cage B(9)-H bond of o-carboranes. This new protocol furnishes a broad...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
29 August 2025
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| In: |
Organic letters
Year: 2025, Jahrgang: 27, Heft: 34, Pages: 9405-9411 |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/acs.orglett.5c02683 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1021/acs.orglett.5c02683
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| Verfasserangaben: | Huiyuan Zheng, Yue Hao, Yongqiang Wang, Xue Zhao, Ximei Zhao, Liang Xu, A. Stephen K. Hashmi, and Guanghui Wang |
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| 245 | 1 | 0 | |a Gold-catalyzed highly regioselective cage B(9)-H alkylation of o-carboranes with 1,6-enynes |c Huiyuan Zheng, Yue Hao, Yongqiang Wang, Xue Zhao, Ximei Zhao, Liang Xu, A. Stephen K. Hashmi, and Guanghui Wang |
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| 520 | |a Described herein is a gold-catalyzed regioselective B(9)-H alkylation of o-carboranes via regioselective insertion of exo-cyclopropyl gold carbenes, generated in situ by gold-catalyzed 5-exo-dig cyclization of 1,6-enynes, into the cage B(9)-H bond of o-carboranes. This new protocol furnishes a broad range of B(9)-bicyclo[3.1.0]hexylmethyl-o-carboranes in moderate to good yields (up to 83%) with good to excellent regioselectivities (B(9)/B(8) up to 100:0). Besides, a gold-catalyzed regioselective cage B(9)-H alkylation of m-carboranes with 1,6-enynes is realized for the first time. | ||
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| 700 | 1 | |a Wang, Yongqiang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhao, Xue |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhao, Ximei |e VerfasserIn |4 aut | |
| 700 | 1 | |a Xu, Liang |e VerfasserIn |4 aut | |
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