Efficient finetuning of foundation model combined with few-shot learning improves pattern recognition in histopathology
Neural networks have achieved state-of-the-art performance in classifying whole slide image (WSI) patches in histopathology through supervised learning. However, their reliance on large-scale annotated datasets imposes a substantial labeling burden, limiting the practical benefits of AI-assisted dia...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 November 2025
|
| In: |
Virchows Archiv
|
| ISSN: | 1432-2307 |
| DOI: | 10.1007/s00428-025-04351-8 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00428-025-04351-8
|
| Verfasserangaben: | Ayk Jessen, Christoph Blattgerste, Maximilian Legnar, Zoran V. Popovic, Stefan Porubsky, Cleo-Aron Weis |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1948506378 | ||
| 003 | DE-627 | ||
| 005 | 20260113085700.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260112s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00428-025-04351-8 |2 doi | |
| 035 | |a (DE-627)1948506378 | ||
| 035 | |a (DE-599)KXP1948506378 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Jessen, Ayk |e VerfasserIn |0 (DE-588)1386554502 |0 (DE-627)1948536005 |4 aut | |
| 245 | 1 | 0 | |a Efficient finetuning of foundation model combined with few-shot learning improves pattern recognition in histopathology |c Ayk Jessen, Christoph Blattgerste, Maximilian Legnar, Zoran V. Popovic, Stefan Porubsky, Cleo-Aron Weis |
| 264 | 1 | |c 27 November 2025 | |
| 300 | |b Illustrationen, Diagramme | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.01.2026 | ||
| 520 | |a Neural networks have achieved state-of-the-art performance in classifying whole slide image (WSI) patches in histopathology through supervised learning. However, their reliance on large-scale annotated datasets imposes a substantial labeling burden, limiting the practical benefits of AI-assisted diagnostics. Foundation models, pretrained on diverse datasets for multi-purpose applications, offer a promising alternative by enabling out-of-the-box generalization. Despite their success in other domains, these models currently underperform in histopathology due to domain-specific challenges. In this work, we introduce a fine-tuning pipeline that significantly enhances the performance of foundation models for histopathological classification using only a minimal amount of labeled data. Specifically, we curate an unlabeled dataset from the target domain and employ self-supervised learning (SSL) to adapt pretrained Vision Transformers (ViTs). Our approach substantially improves classification accuracy while reducing annotation requirements, making foundation models more suitable for histopathological analysis. Furthermore, our results show that SSL-trained models can extract richer features even without access to class labels or balanced training data. | ||
| 650 | 4 | |a Few-shot learning | |
| 650 | 4 | |a Foundation models | |
| 650 | 4 | |a Histopathology | |
| 650 | 4 | |a Self-supervised learning | |
| 650 | 4 | |a Vision transformer | |
| 700 | 1 | |a Blattgerste, Christoph |e VerfasserIn |0 (DE-588)1201618665 |0 (DE-627)1685706177 |4 aut | |
| 700 | 1 | |a Legnar, Maximilian |e VerfasserIn |0 (DE-588)1259378357 |0 (DE-627)1806294826 |4 aut | |
| 700 | 1 | |a Popovic, Zoran V. |d 1974- |e VerfasserIn |0 (DE-588)134052390 |0 (DE-627)55988852X |0 (DE-576)277561051 |4 aut | |
| 700 | 1 | |a Porubský, Štefan |d 1977- |e VerfasserIn |0 (DE-588)12958844X |0 (DE-627)473362341 |0 (DE-576)29773637X |4 aut | |
| 700 | 1 | |a Weis, Cleo-Aron Thias |d 1985- |e VerfasserIn |0 (DE-588)1062803752 |0 (DE-627)806961198 |0 (DE-576)42022730X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Virchows Archiv |d Berlin : Springer, 1847 |g (2025) |h Online-Ressource |w (DE-627)254910645 |w (DE-600)1463276-7 |w (DE-576)074754416 |x 1432-2307 |7 nnas |a Efficient finetuning of foundation model combined with few-shot learning improves pattern recognition in histopathology |
| 773 | 1 | 8 | |g year:2025 |g extent:11 |a Efficient finetuning of foundation model combined with few-shot learning improves pattern recognition in histopathology |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00428-025-04351-8 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |7 1 |
| 951 | |a AR | ||
| 992 | |a 20260112 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1062803752 |a Weis, Cleo-Aron Thias |m 1062803752:Weis, Cleo-Aron Thias |d 910000 |d 912000 |d 50000 |e 910000PW1062803752 |e 912000PW1062803752 |e 50000PW1062803752 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 6 |y j | ||
| 998 | |g 12958844X |a Porubský, Štefan |m 12958844X:Porubský, Štefan |p 5 | ||
| 998 | |g 134052390 |a Popovic, Zoran V. |m 134052390:Popovic, Zoran V. |d 60000 |d 63400 |e 60000PP134052390 |e 63400PP134052390 |k 0/60000/ |k 1/60000/63400/ |p 4 | ||
| 998 | |g 1259378357 |a Legnar, Maximilian |m 1259378357:Legnar, Maximilian |d 60000 |d 63400 |e 60000PL1259378357 |e 63400PL1259378357 |k 0/60000/ |k 1/60000/63400/ |p 3 | ||
| 998 | |g 1201618665 |a Blattgerste, Christoph |m 1201618665:Blattgerste, Christoph |d 130000 |d 60000 |e 130000PB1201618665 |e 60000PB1201618665 |k 0/130000/ |k 0/60000/ |p 2 | ||
| 998 | |g 1386554502 |a Jessen, Ayk |m 1386554502:Jessen, Ayk |d 910000 |d 912000 |d 50000 |e 910000PJ1386554502 |e 912000PJ1386554502 |e 50000PJ1386554502 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1948506378 |e 4845344319 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"noteIll":"Illustrationen, Diagramme","extent":"11 S."}],"note":["Gesehen am 12.01.2026"],"person":[{"roleDisplay":"VerfasserIn","role":"aut","display":"Jessen, Ayk","family":"Jessen","given":"Ayk"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Blattgerste, Christoph","given":"Christoph","family":"Blattgerste"},{"role":"aut","display":"Legnar, Maximilian","roleDisplay":"VerfasserIn","family":"Legnar","given":"Maximilian"},{"role":"aut","display":"Popovic, Zoran V.","roleDisplay":"VerfasserIn","family":"Popovic","given":"Zoran V."},{"given":"Štefan","family":"Porubský","roleDisplay":"VerfasserIn","role":"aut","display":"Porubský, Štefan"},{"display":"Weis, Cleo-Aron Thias","role":"aut","roleDisplay":"VerfasserIn","given":"Cleo-Aron Thias","family":"Weis"}],"name":{"displayForm":["Ayk Jessen, Christoph Blattgerste, Maximilian Legnar, Zoran V. Popovic, Stefan Porubsky, Cleo-Aron Weis"]},"id":{"doi":["10.1007/s00428-025-04351-8"],"eki":["1948506378"]},"recId":"1948506378","type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Efficient finetuning of foundation model combined with few-shot learning improves pattern recognition in histopathology","title":"Efficient finetuning of foundation model combined with few-shot learning improves pattern recognition in histopathology"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 06.12.05"],"pubHistory":["1.1847 -"],"id":{"eki":["254910645"],"issn":["1432-2307"],"zdb":["1463276-7"]},"recId":"254910645","corporate":[{"display":"European Society of Pathology","role":"isb","roleDisplay":"Herausgebendes Organ"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"year":"2025","extent":"11","text":"(2025)"},"disp":"Efficient finetuning of foundation model combined with few-shot learning improves pattern recognition in histopathologyVirchows Archiv","language":["eng"],"titleAlt":[{"title":"Archiv für pathologische Anatomie und Physiologie und für klinische Medicin"},{"title":"Virchows Archiv für pathologische Anatomie und Physiologie und für klinische Medizin"},{"title":"Virchows Archiv / A"}],"title":[{"title_sort":"Virchows Archiv","title":"Virchows Archiv","subtitle":"official journal of the European Society of Pathology"}],"origin":[{"publisher":"Springer","dateIssuedDisp":"1847-","dateIssuedKey":"1847","publisherPlace":"Berlin ; Heidelberg"}]}],"origin":[{"dateIssuedDisp":"27 November 2025","dateIssuedKey":"2025"}],"language":["eng"]} | ||
| SRT | |a JESSENAYKBEFFICIENTF2720 | ||