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Toxicities in long-term survivors of head and neck cancer: a multi-national cross-sectional analysis

Head and neck cancer (HNC) patients may experience toxicities as a result of their treatment modality. While acute toxicities have been well documented, the prevalence of toxicities at long-term follow-up of HNC survivors is less clear. As part of a multi-national, cross-sectional study, HNC survivo...

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Hauptverfasser: Taylor, Katherine Joyce (VerfasserIn) , Amdal, Cecilie D. (VerfasserIn) , Bjordal, Kristin (VerfasserIn) , Astrup, Guro L. (VerfasserIn) , Herlofson, Bente B. (VerfasserIn) , Duprez, Fréderic (VerfasserIn) , Gama, Ricardo R. (VerfasserIn) , Jacinto, Alexandre (VerfasserIn) , Hammerlid, Eva (VerfasserIn) , Scricciolo, Melissa (VerfasserIn) , Jansen, Femke (VerfasserIn) , Verdonck-de Leeuw, Irma M. (VerfasserIn) , Fanetti, Giuseppe (VerfasserIn) , Guntinas-Lichius, Orlando (VerfasserIn) , Inhestern, Johanna (VerfasserIn) , Dragan, Tatiana (VerfasserIn) , Fabian, Alexander (VerfasserIn) , Boehm, Andreas (VerfasserIn) , Wöhner, Ulrike (VerfasserIn) , Kiyota, Naomi (VerfasserIn) , Krüger, Maximilian (VerfasserIn) , Bonomo, Pierluigi (VerfasserIn) , Pinto, Monica (VerfasserIn) , Nuyts, Sandra (VerfasserIn) , Silva, Joaquim Castro (VerfasserIn) , Stromberger, Carmen (VerfasserIn) , Specenier, Pol (VerfasserIn) , Tramacere, Francesco (VerfasserIn) , Bushnak, Ayman (VerfasserIn) , Perotti, Pietro (VerfasserIn) , Plath, Michaela (VerfasserIn) , Paderno, Alberto (VerfasserIn) , Stempler, Noa (VerfasserIn) , Kouri, Maria (VerfasserIn) , Grégoire, Vincent (VerfasserIn) , Tribius, Silke (VerfasserIn) , Singer, Susanne (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 30 July 2025
In: International journal of cancer
Year: 2025, Jahrgang: 157, Heft: 10, Pages: 2061-2070
ISSN:1097-0215
DOI:10.1002/ijc.70033
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/ijc.70033
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.70033
Volltext
Verfasserangaben:Katherine J. Taylor, Cecilie D. Amdal, Kristin Bjordal, Guro L. Astrup, Bente B. Herlofson, Fréderic Duprez, Ricardo R. Gama, Alexandre Jacinto, Eva Hammerlid, Melissa Scricciolo, Femke Jansen, Irma M. Verdonck-de Leeuw, Giuseppe Fanetti, Orlando Guntinas-Lichius, Johanna Inhestern, Tatiana Dragan, Alexander Fabian, Andreas Boehm, Ulrike Wöhner, Naomi Kiyota, Maximilian Krüger, Pierluigi Bonomo, Monica Pinto, Sandra Nuyts, Joaquim Castro Silva, Carmen Stromberger, Pol Specenier, Francesco Tramacere, Ayman Bushnak, Pietro Perotti, Michaela Plath, Alberto Paderno, Noa Stempler, Maria Kouri, Vincent Grégoire, Silke Tribius, Susanne Singer, on behalf of the EORTC Quality of Life Group and the EORTC Head and Neck Group
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Zusammenfassung:Head and neck cancer (HNC) patients may experience toxicities as a result of their treatment modality. While acute toxicities have been well documented, the prevalence of toxicities at long-term follow-up of HNC survivors is less clear. As part of a multi-national, cross-sectional study, HNC survivors at least 5 years post-diagnosis were invited to undergo a toxicity examination. Using the Common Terminology Criteria for Adverse Events (version 5), 33 toxicities were assessed. From 2019 to 2021, 1094 survivors from 26 sites in 11 countries completed the assessment. Eighty-seven percent were from Europe, and most were survivors of oropharynx (35%), oral cavity (21%), or larynx cancer (19%). The majority had been diagnosed at stage III or IV (62%), and the median time since diagnosis was 8 years (range 5-36). Most had been treated with surgery and radiotherapy with or without chemotherapy (38%). Six percent had no toxicities, and 26% had only mild toxicities. 68% had at least one moderate or severe late toxicity. Overall, the most frequent late toxicities at any grade were dry mouth (67%), soft tissue fibrosis (52%), dysphagia (51%), and voice alterations (39%). Fistulae, neck and face edema, and osteonecrosis of the jaws were present in very few survivors. Our study shows that the majority of HNC survivors experience moderate or severe late toxicities, but that the problems are concentrated in a small group of specific toxicities. Understanding the problems experienced in the long term can help better inform newly diagnosed patients as well as inform survivorship follow-up initiatives.
Beschreibung:Gesehen am 12.01.2026
Beschreibung:Online Resource
ISSN:1097-0215
DOI:10.1002/ijc.70033

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