Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment
Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by the dilation of the abdominal aorta, leading to a high risk of rupture. Current treatment options are limited, particularly for patients ineligible for surgical interventions. This study explores a novel immunotherapeut...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 August 2025
|
| In: |
Communications biology
Year: 2025, Jahrgang: 8, Pages: 1-16 |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-025-08604-9 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s42003-025-08604-9 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s42003-025-08604-9 
|
| Verfasserangaben: | Qingwei Gang, Yu Lun, Xiaoxu Zhang, Jamol Uzokov, Han Jiang, Yuchen He, Shikai Shen, Shiyue Wang, Philipp Erhart, Dittmar Böckler, Yuemeng Li, Yanshuo Han & Jian Zhang |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1948546868 | ||
| 003 | DE-627 | ||
| 005 | 20260113100459.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260113s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s42003-025-08604-9 |2 doi | |
| 035 | |a (DE-627)1948546868 | ||
| 035 | |a (DE-599)KXP1948546868 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Gang, Qingwei |e VerfasserIn |0 (DE-588)1386561711 |0 (DE-627)1948547783 |4 aut | |
| 245 | 1 | 0 | |a Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment |c Qingwei Gang, Yu Lun, Xiaoxu Zhang, Jamol Uzokov, Han Jiang, Yuchen He, Shikai Shen, Shiyue Wang, Philipp Erhart, Dittmar Böckler, Yuemeng Li, Yanshuo Han & Jian Zhang |
| 246 | 3 | 3 | |a Targeting VCAM-one with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment |
| 264 | 1 | |c 15 August 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Veröffentlicht: 15. August 2025 | ||
| 500 | |a Gesehen am 13.01.2026 | ||
| 520 | |a Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by the dilation of the abdominal aorta, leading to a high risk of rupture. Current treatment options are limited, particularly for patients ineligible for surgical interventions. This study explores a novel immunotherapeutic approach using chimeric antigen receptor Treg cells targeting vascular cell adhesion molecule-1 (VCAM-1) to mitigate AAA progression. By leveraging the specificity and regulatory function of CAR-Treg cells, our research aims to modulate the immune response and reduce inflammation in the aneurysmal wall. Results from preclinical mouse models demonstrated that CAR-Treg cells effectively homed to the aneurysmal site, suppressed local inflammation, and decreased aortic dilation compared to control groups. These findings suggest that CAR-Treg cell therapy could provide a promising, non-surgical treatment option for AAA patients, addressing a critical unmet need in cardiovascular disease management. | ||
| 650 | 4 | |a Aneurysm | |
| 650 | 4 | |a Molecular medicine | |
| 650 | 4 | |a Translational research | |
| 700 | 1 | |a Lun, Yu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhang, Xiaoxu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Uzokov, Jamol |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jiang, Han |e VerfasserIn |4 aut | |
| 700 | 1 | |a He, Yuchen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Shen, Shikai |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wang, Shiyue |e VerfasserIn |4 aut | |
| 700 | 1 | |a Erhart, Philipp |d 1985- |e VerfasserIn |0 (DE-588)1059127172 |0 (DE-627)798020733 |0 (DE-576)41026699X |4 aut | |
| 700 | 1 | |a Böckler, Dittmar |d 1966- |e VerfasserIn |0 (DE-588)1032367881 |0 (DE-627)738382868 |0 (DE-576)173503969 |4 aut | |
| 700 | 1 | |a Li, Yuemeng |e VerfasserIn |4 aut | |
| 700 | 1 | |a Han, Yanshuo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhang, Jian |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Communications biology |d London : Springer Nature, 2018 |g 8(2025), Artikel-ID 1230, Seite 1-16 |h Online-Ressource |w (DE-627)101369080X |w (DE-600)2919698-X |w (DE-576)499739132 |x 2399-3642 |7 nnas |a Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment |
| 773 | 1 | 8 | |g volume:8 |g year:2025 |g elocationid:1230 |g pages:1-16 |g extent:16 |a Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s42003-025-08604-9 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s42003-025-08604-9 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20260113 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1032367881 |a Böckler, Dittmar |m 1032367881:Böckler, Dittmar |d 910000 |d 910200 |e 910000PB1032367881 |e 910200PB1032367881 |k 0/910000/ |k 1/910000/910200/ |p 10 | ||
| 998 | |g 1059127172 |a Erhart, Philipp |m 1059127172:Erhart, Philipp |d 910000 |d 910200 |d 50000 |e 910000PE1059127172 |e 910200PE1059127172 |e 50000PE1059127172 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 9 | ||
| 999 | |a KXP-PPN1948546868 |e 4845829029 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1948546868","person":[{"given":"Qingwei","display":"Gang, Qingwei","role":"aut","family":"Gang"},{"family":"Lun","role":"aut","given":"Yu","display":"Lun, Yu"},{"family":"Zhang","role":"aut","given":"Xiaoxu","display":"Zhang, Xiaoxu"},{"role":"aut","family":"Uzokov","given":"Jamol","display":"Uzokov, Jamol"},{"display":"Jiang, Han","given":"Han","family":"Jiang","role":"aut"},{"given":"Yuchen","display":"He, Yuchen","role":"aut","family":"He"},{"display":"Shen, Shikai","given":"Shikai","family":"Shen","role":"aut"},{"role":"aut","family":"Wang","display":"Wang, Shiyue","given":"Shiyue"},{"display":"Erhart, Philipp","given":"Philipp","family":"Erhart","role":"aut"},{"given":"Dittmar","display":"Böckler, Dittmar","family":"Böckler","role":"aut"},{"given":"Yuemeng","display":"Li, Yuemeng","family":"Li","role":"aut"},{"display":"Han, Yanshuo","given":"Yanshuo","family":"Han","role":"aut"},{"given":"Jian","display":"Zhang, Jian","family":"Zhang","role":"aut"}],"name":{"displayForm":["Qingwei Gang, Yu Lun, Xiaoxu Zhang, Jamol Uzokov, Han Jiang, Yuchen He, Shikai Shen, Shiyue Wang, Philipp Erhart, Dittmar Böckler, Yuemeng Li, Yanshuo Han & Jian Zhang"]},"relHost":[{"origin":[{"publisherPlace":"London","dateIssuedDisp":"[2018]-","publisher":"Springer Nature"}],"title":[{"title":"Communications biology","title_sort":"Communications biology"}],"disp":"Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatmentCommunications biology","type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"issn":["2399-3642"],"eki":["101369080X"],"zdb":["2919698-X"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"101369080X","pubHistory":["1 (2018)-"],"language":["eng"],"part":{"year":"2025","volume":"8","text":"8(2025), Artikel-ID 1230, Seite 1-16","extent":"16","pages":"1-16"}}],"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"15 August 2025"}],"title":[{"title_sort":"Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment","title":"Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment"}],"physDesc":[{"extent":"16 S.","noteIll":"Illustrationen"}],"id":{"eki":["1948546868"],"doi":["10.1038/s42003-025-08604-9"]},"note":["Veröffentlicht: 15. August 2025","Gesehen am 13.01.2026"],"language":["eng"],"titleAlt":[{"title":"Targeting VCAM-one with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment"}],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a GANGQINGWETARGETINGV1520 | ||