Systemic inactivation of TREX1 induces selective inflammation of the tumor microenvironment and invigorated T-cell-mediated tumor control
Therapeutic innate immune-stimulation within the tumor microenvironment can potentiate endogenous antitumor T-cell immunity. Strategies for controlled activation of cGAS/STING signaling are currently under intense investigation. DNase 3′-repair exonuclease 1 (TREX1) is essential for cellular DNA dis...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 August 2025
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| In: |
Cancer research
Year: 2025, Jahrgang: 85, Heft: 15, Pages: 2876-2889 |
| ISSN: | 1538-7445 |
| DOI: | 10.1158/0008-5472.CAN-24-2262 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/0008-5472.CAN-24-2262 |
| Verfasserangaben: | Emilija Marinkovic, Minyi Chen, Nadja Schubert, Elif Dogan Dar, Tanja Poth, Janet Y. Leung, Jack Lohre, Jennifer M. Sahni, Christine Tun, Pavithra Rajeswaran, Tanja Mehlo-Jensen, Olivia Perng, C. Mark Hill, Pallavur Sivakumar, Michael J. Barnes, Rohit Malik, Rayk Behrendt, and Axel Roers |
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