Cover Image

Implementing PEN-FAST for penicillin allergy delabeling in a high-prevalence population

Background and objectives Self-reported penicillin allergies lead to the use of broad-spectrum antibiotics, increase drug resistance, and constitute an economic burden. The PEN-FAST score aims to identify low-risk patients for direct drug provocation tests (DPT) without prior skin testing with a rep...

Full description

Saved in:
Bibliographic Details
Main Authors: Göcebe, Deniz (Author) , Kommoss, Katharina (Author) , Hartmann, Martin (Author) , Enk, Alexander (Author) , Schäkel, Knut (Author)
Format: Article (Journal)
Language:English
Published: January 2026
In: Journal der Deutschen Dermatologischen Gesellschaft
Year: 2026, Volume: 24, Issue: 1, Pages: 57-63
ISSN:1610-0387
DOI:10.1111/ddg.15862
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/ddg.15862
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.15862
Get full text
Author Notes:Deniz Göcebe, Katharina S. Kommoss, Martin Hartmann, Alexander H. Enk, Knut Schäkel

MARC

LEADER 00000naa a2200000 c 4500
001 194898945X
003 DE-627
005 20260116084432.0
007 cr uuu---uuuuu
008 260116s2026 xx |||||o 00| ||eng c
024 7 |a 10.1111/ddg.15862  |2 doi 
035 |a (DE-627)194898945X 
035 |a (DE-599)KXP194898945X 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Göcebe, Deniz  |d 1996-  |e VerfasserIn  |0 (DE-588)1289672601  |0 (DE-627)1845624327  |4 aut 
245 1 0 |a Implementing PEN-FAST for penicillin allergy delabeling in a high-prevalence population  |c Deniz Göcebe, Katharina S. Kommoss, Martin Hartmann, Alexander H. Enk, Knut Schäkel 
264 1 |c January 2026 
300 |b Diagramme 
300 |a 7 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Veröffentlicht: 14 September 2025 
500 |a Gesehen am 16.01.2026 
520 |a Background and objectives Self-reported penicillin allergies lead to the use of broad-spectrum antibiotics, increase drug resistance, and constitute an economic burden. The PEN-FAST score aims to identify low-risk patients for direct drug provocation tests (DPT) without prior skin testing with a reported negative predictive value (NPV) of over 95%. Patients and methods In this single-center study (Department of Dermatology, University Hospital Heidelberg, Germany), the PEN-FAST score was evaluated for patients carrying a penicillin allergy label between 2004 and 2024. Skin testing, allergen-specific IgE, and consecutive DPT were performed. Results A total of 189 patients were analyzed. In a retrospective cohort, 106 of 149 patients showed negative skin tests and received DPT, leading to the delabeling of 99 patients (66.4%). PEN-FAST identified 55 of 149 (36.9%) as low-risk, of which three low-risk patients were misclassified. In a prospective PEN-FAST low-risk cohort, one of 40 patients showed a mild reaction after DPT. Overall, NPVs of both PEN-FAST and formal allergy testing were 95.8%. Conclusions Our results advocate for direct DPT in patients carrying a penicillin allergy label classified as low-risk by PEN-FAST. PEN-FAST demonstrated high NPV, safety, and feasibility in a cohort with a high prevalence of true allergies. 
650 4 |a Allergy delabeling 
650 4 |a drug allergy 
650 4 |a PEN-FAST 
650 4 |a penicillin allergy 
700 1 |a Kommoss, Katharina  |e VerfasserIn  |0 (DE-588)1216661227  |0 (DE-627)1727913124  |4 aut 
700 1 |a Hartmann, Martin  |d 1964-  |e VerfasserIn  |0 (DE-588)134168984  |0 (DE-627)562112952  |0 (DE-576)278491081  |4 aut 
700 1 |a Enk, Alexander  |d 1963-  |e VerfasserIn  |0 (DE-588)1032757140  |0 (DE-627)739272535  |0 (DE-576)166173517  |4 aut 
700 1 |a Schäkel, Knut  |e VerfasserIn  |0 (DE-588)1032757418  |0 (DE-627)739272896  |0 (DE-576)251064476  |4 aut 
773 0 8 |i Enthalten in  |a Deutsche Dermatologische Gesellschaft  |t Journal der Deutschen Dermatologischen Gesellschaft  |d Berlin : Wiley-Blackwell, 2003  |g 24(2026), 1 vom: Jan., Seite 57-63  |h Online-Ressource  |w (DE-627)362755833  |w (DE-600)2099463-1  |w (DE-576)103373837  |x 1610-0387  |7 nnas 
773 1 8 |g volume:24  |g year:2026  |g number:1  |g month:01  |g pages:57-63  |g extent:7  |a Implementing PEN-FAST for penicillin allergy delabeling in a high-prevalence population 
856 4 0 |u https://doi.org/10.1111/ddg.15862  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext  |7 0 
856 4 0 |u https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.15862  |x Verlag  |z kostenfrei  |3 Volltext  |7 0 
951 |a AR 
992 |a 20260116 
993 |a Article 
994 |a 2026 
998 |g 1032757418  |a Schäkel, Knut  |m 1032757418:Schäkel, Knut  |d 910000  |d 911300  |e 910000PS1032757418  |e 911300PS1032757418  |k 0/910000/  |k 1/910000/911300/  |p 5  |y j 
998 |g 1032757140  |a Enk, Alexander  |m 1032757140:Enk, Alexander  |d 910000  |d 911300  |e 910000PE1032757140  |e 911300PE1032757140  |k 0/910000/  |k 1/910000/911300/  |p 4 
998 |g 134168984  |a Hartmann, Martin  |m 134168984:Hartmann, Martin  |d 910000  |d 911700  |d 50000  |e 910000PH134168984  |e 911700PH134168984  |e 50000PH134168984  |k 0/910000/  |k 1/910000/911700/  |k 0/50000/  |p 3 
998 |g 1216661227  |a Kommoss, Katharina  |m 1216661227:Kommoss, Katharina  |d 910000  |d 911300  |e 910000PK1216661227  |e 911300PK1216661227  |k 0/910000/  |k 1/910000/911300/  |p 2 
998 |g 1289672601  |a Göcebe, Deniz  |m 1289672601:Göcebe, Deniz  |d 910000  |d 910100  |e 910000PG1289672601  |e 910100PG1289672601  |k 0/910000/  |k 1/910000/910100/  |p 1  |x j 
999 |a KXP-PPN194898945X  |e 4850103383 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Deniz Göcebe, Katharina S. Kommoss, Martin Hartmann, Alexander H. Enk, Knut Schäkel"]},"recId":"194898945X","note":["Veröffentlicht: 14 September 2025","Gesehen am 16.01.2026"],"origin":[{"dateIssuedDisp":"January 2026","dateIssuedKey":"2026"}],"language":["eng"],"id":{"eki":["194898945X"],"doi":["10.1111/ddg.15862"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"given":"Deniz","display":"Göcebe, Deniz","family":"Göcebe","role":"aut"},{"role":"aut","display":"Kommoss, Katharina","family":"Kommoss","given":"Katharina"},{"role":"aut","given":"Martin","family":"Hartmann","display":"Hartmann, Martin"},{"role":"aut","display":"Enk, Alexander","family":"Enk","given":"Alexander"},{"given":"Knut","display":"Schäkel, Knut","family":"Schäkel","role":"aut"}],"physDesc":[{"noteIll":"Diagramme","extent":"7 S."}],"title":[{"title":"Implementing PEN-FAST for penicillin allergy delabeling in a high-prevalence population","title_sort":"Implementing PEN-FAST for penicillin allergy delabeling in a high-prevalence population"}],"relHost":[{"id":{"issn":["1610-0387"],"zdb":["2099463-1"],"doi":["10.1111/(ISSN)1610-0387"],"eki":["362755833"]},"corporate":[{"role":"aut","display":"Deutsche Dermatologische Gesellschaft"}],"language":["ger","eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"362755833","pubHistory":["1.2003 -"],"note":["Gesehen am 03.03.10"],"disp":"Deutsche Dermatologische GesellschaftJournal der Deutschen Dermatologischen Gesellschaft","physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Journal der Deutschen Dermatologischen Gesellschaft","subtitle":"JDDG = Journal of the German Society of Dermatology","title":"Journal der Deutschen Dermatologischen Gesellschaft"}],"titleAlt":[{"title":"JDDG"}],"titleTranslated":[{"translated":"Journal of the German Society of Dermatology"}],"part":{"year":"2026","extent":"7","issue":"1","volume":"24","pages":"57-63","text":"24(2026), 1 vom: Jan., Seite 57-63"},"origin":[{"publisher":"Wiley-Blackwell ; Blackwell","dateIssuedKey":"2003","publisherPlace":"Berlin ; Berlin","dateIssuedDisp":"2003-"}]}]} 
SRT |a GOECEBEDENIMPLEMENTI2026 

Similar Items