Mechanical thrombectomy for large ischemic stroke: a critical appraisal of evidence from 6 randomized controlled trials
Recently, 6 randomized trials evaluated the efficacy and safety of endovascular thrombectomy in patients with large core stroke. This review examines the differences in clinical and imaging eligibility and their impact on the interpretation of evidence and potential neuroimaging workflow. Pending re...
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| Hauptverfasser: | , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2025
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| In: |
Stroke
Year: 2025, Jahrgang: 56, Heft: 7, Pages: 1917-1927 |
| ISSN: | 1524-4628 |
| DOI: | 10.1161/STROKEAHA.125.050402 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1161/STROKEAHA.125.050402 Verlag, kostenfrei, Volltext: https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.050402 
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| Verfasserangaben: | Amrou Sarraj, Shinichi Yoshimura, Götz Thomalla, Xiaochuan Huo, Caroline Arquizan, Albert J. Yoo, Takeshi Morimoto, Martin Bendszus, Bertrand Lapergue, Thanh N. Nguyen, Bruce C.V. Campbell, Vincent Costalat, Jens Fiehler, Tudor G. Jovin, Osama O. Zaidat, Zhongrong Miao |
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| 520 | |a Recently, 6 randomized trials evaluated the efficacy and safety of endovascular thrombectomy in patients with large core stroke. This review examines the differences in clinical and imaging eligibility and their impact on the interpretation of evidence and potential neuroimaging workflow. Pending results of a planned patient-level meta-analysis, it also evaluates clinical outcomes and thrombectomy treatment effect across those trials, overall and within selected clinical and imaging subgroups most relevant to clinical practice. Additionally, the implications of extending thrombectomy eligibility to patients with large core stroke on stroke systems of care and societal benefits are discussed. | ||
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| 700 | 1 | |a Arquizan, Caroline |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yoo, Albert J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Morimoto, Takeshi |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Miao, Zhongrong |e VerfasserIn |4 aut | |
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