Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation
The lysine-specific demethylase 1 (LSD1) regulates hematopoietic stem cell differentiation and has been identified as a therapeutic target in hematological disorders. LSD1 demethylates mono and dimethylated histones 3 at lysine 4 and 9. In addition, it acts as a scaffold for the formation of chromat...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 August 2025
|
| In: |
Cell death & disease
Year: 2025, Jahrgang: 16, Pages: 1-14 |
| ISSN: | 2041-4889 |
| DOI: | 10.1038/s41419-025-07951-z |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41419-025-07951-z Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41419-025-07951-z 
|
| Verfasserangaben: | Hans Felix Staehle, Christoph Koellerer, Anne Marie Staehle, Jana Schulze, Philipp Eble, Anja Müller, Franziska Zell, Judith M. Müller, Florian Perner, Aya Attia, Jan-Philipp Mallm, Olga Pozdnyakova, Karsten Rippe, Benedikt Brors, Lars Feuerbach, Charles D. Imbusch, Eric Metzger, Roland Schüle, Heike L. Pahl and Jonas S. Jutzi |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1949671933 | ||
| 003 | DE-627 | ||
| 005 | 20260120102359.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260120s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41419-025-07951-z |2 doi | |
| 035 | |a (DE-627)1949671933 | ||
| 035 | |a (DE-599)KXP1949671933 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Staehle, Hans Felix |d 1992- |e VerfasserIn |0 (DE-588)1227969899 |0 (DE-627)1749197170 |4 aut | |
| 245 | 1 | 0 | |a Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation |c Hans Felix Staehle, Christoph Koellerer, Anne Marie Staehle, Jana Schulze, Philipp Eble, Anja Müller, Franziska Zell, Judith M. Müller, Florian Perner, Aya Attia, Jan-Philipp Mallm, Olga Pozdnyakova, Karsten Rippe, Benedikt Brors, Lars Feuerbach, Charles D. Imbusch, Eric Metzger, Roland Schüle, Heike L. Pahl and Jonas S. Jutzi |
| 246 | 3 | 0 | |a one |
| 264 | 1 | |c 15 August 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 15. August 2025 | ||
| 500 | |a Gesehen am 20.01.2026 | ||
| 520 | |a The lysine-specific demethylase 1 (LSD1) regulates hematopoietic stem cell differentiation and has been identified as a therapeutic target in hematological disorders. LSD1 demethylates mono and dimethylated histones 3 at lysine 4 and 9. In addition, it acts as a scaffold for the formation of chromatin-modifying complexes that regulates the transcription of myeloid-lineage-specific genes in complex with GFI1, a transcriptional repressor. While both enzymatic and non-enzymatic functions of LSD1 have been well defined, the relative importance of these two functions in hematopoiesis remains incompletely understood. Here, we investigated the contribution of enzymatic and non-enzymatic functions of LSD1 to myelopoiesis. We show that myeloid differentiation is independent of the enzymatic functions of LSD1 but requires the non-enzymatic, scaffolding function, which directs GFI1 binding to target sequences. In the absence of the LSD1 protein, GFI1 DNA binding is diminished, and myeloid cell differentiation arrests at an immature, myelomonocytic-like cell stage, which overexpresses Prtn3. We provide functional data implicating Prtn3 as an effector of the stem cell expansion and myeloid maturation block caused by the loss of LSD1. | ||
| 650 | 4 | |a Epigenetics | |
| 650 | 4 | |a Haematopoietic stem cells | |
| 650 | 4 | |a Myelopoiesis | |
| 650 | 4 | |a Transcriptomics | |
| 700 | 1 | |a Koellerer, Christoph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Staehle, Anne Marie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schulze, Jana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Eble, Philipp |e VerfasserIn |4 aut | |
| 700 | 1 | |a Müller, Anja |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zell, Franziska |e VerfasserIn |4 aut | |
| 700 | 1 | |a Müller, Judith M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Perner, Florian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Attia, Aya |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mallm, Jan-Philipp |e VerfasserIn |0 (DE-588)1029962413 |0 (DE-627)734535619 |0 (DE-576)377783358 |4 aut | |
| 700 | 1 | |a Pozdnyakova, Olga |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rippe, Karsten |e VerfasserIn |0 (DE-588)102853261X |0 (DE-627)730885070 |0 (DE-576)168897989 |4 aut | |
| 700 | 1 | |a Brors, Benedikt |e VerfasserIn |0 (DE-588)1112102965 |0 (DE-627)866068732 |0 (DE-576)476376157 |4 aut | |
| 700 | 1 | |a Feuerbach, Lars |e VerfasserIn |0 (DE-588)1182043062 |0 (DE-627)1662532075 |4 aut | |
| 700 | 1 | |a Imbusch, Charles |e VerfasserIn |0 (DE-588)1193524474 |0 (DE-627)1672263824 |4 aut | |
| 700 | 1 | |a Metzger, Eric |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schüle, Roland |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pahl, Heike L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jutzi, Jonas S. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell death & disease |d London [u.a.] : Nature Publishing Group, 2010 |g 16(2025), Artikel-ID 619, Seite 1-14 |h Online-Ressource |w (DE-627)620145250 |w (DE-600)2541626-1 |w (DE-576)319429059 |x 2041-4889 |7 nnas |a Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation |
| 773 | 1 | 8 | |g volume:16 |g year:2025 |g elocationid:619 |g pages:1-14 |g extent:14 |a Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41419-025-07951-z |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41419-025-07951-z |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20260120 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1193524474 |a Imbusch, Charles |m 1193524474:Imbusch, Charles |p 16 | ||
| 998 | |g 1182043062 |a Feuerbach, Lars |m 1182043062:Feuerbach, Lars |d 160000 |e 160000PF1182043062 |k 0/160000/ |p 15 | ||
| 998 | |g 1112102965 |a Brors, Benedikt |m 1112102965:Brors, Benedikt |d 50000 |e 50000PB1112102965 |k 0/50000/ |p 14 | ||
| 998 | |g 102853261X |a Rippe, Karsten |m 102853261X:Rippe, Karsten |d 700000 |d 716000 |e 700000PR102853261X |e 716000PR102853261X |k 0/700000/ |k 1/700000/716000/ |p 13 | ||
| 998 | |g 1029962413 |a Mallm, Jan-Philipp |m 1029962413:Mallm, Jan-Philipp |d 700000 |d 716000 |e 700000PM1029962413 |e 716000PM1029962413 |k 0/700000/ |k 1/700000/716000/ |p 11 | ||
| 999 | |a KXP-PPN1949671933 |e 485504203X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation","title_sort":"Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation"}],"name":{"displayForm":["Hans Felix Staehle, Christoph Koellerer, Anne Marie Staehle, Jana Schulze, Philipp Eble, Anja Müller, Franziska Zell, Judith M. Müller, Florian Perner, Aya Attia, Jan-Philipp Mallm, Olga Pozdnyakova, Karsten Rippe, Benedikt Brors, Lars Feuerbach, Charles D. Imbusch, Eric Metzger, Roland Schüle, Heike L. Pahl and Jonas S. Jutzi"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"role":"aut","display":"Staehle, Hans Felix","family":"Staehle","given":"Hans Felix"},{"given":"Christoph","role":"aut","display":"Koellerer, Christoph","family":"Koellerer"},{"given":"Anne Marie","family":"Staehle","display":"Staehle, Anne Marie","role":"aut"},{"role":"aut","display":"Schulze, Jana","family":"Schulze","given":"Jana"},{"given":"Philipp","family":"Eble","display":"Eble, Philipp","role":"aut"},{"given":"Anja","family":"Müller","display":"Müller, Anja","role":"aut"},{"given":"Franziska","display":"Zell, Franziska","role":"aut","family":"Zell"},{"given":"Judith M.","display":"Müller, Judith M.","role":"aut","family":"Müller"},{"given":"Florian","family":"Perner","role":"aut","display":"Perner, Florian"},{"given":"Aya","family":"Attia","display":"Attia, Aya","role":"aut"},{"given":"Jan-Philipp","role":"aut","display":"Mallm, Jan-Philipp","family":"Mallm"},{"given":"Olga","family":"Pozdnyakova","role":"aut","display":"Pozdnyakova, Olga"},{"display":"Rippe, Karsten","role":"aut","family":"Rippe","given":"Karsten"},{"given":"Benedikt","display":"Brors, Benedikt","role":"aut","family":"Brors"},{"family":"Feuerbach","role":"aut","display":"Feuerbach, Lars","given":"Lars"},{"given":"Charles","family":"Imbusch","display":"Imbusch, Charles","role":"aut"},{"display":"Metzger, Eric","role":"aut","family":"Metzger","given":"Eric"},{"display":"Schüle, Roland","role":"aut","family":"Schüle","given":"Roland"},{"family":"Pahl","role":"aut","display":"Pahl, Heike L.","given":"Heike L."},{"given":"Jonas S.","role":"aut","display":"Jutzi, Jonas S.","family":"Jutzi"}],"id":{"doi":["10.1038/s41419-025-07951-z"],"eki":["1949671933"]},"origin":[{"dateIssuedDisp":"15 August 2025","dateIssuedKey":"2025"}],"language":["eng"],"note":["Online veröffentlicht: 15. August 2025","Gesehen am 20.01.2026"],"physDesc":[{"extent":"14 S.","noteIll":"Illustrationen"}],"recId":"1949671933","relHost":[{"pubHistory":["1.2010 -"],"language":["eng"],"origin":[{"dateIssuedDisp":"2010-","publisherPlace":"London [u.a.]","dateIssuedKey":"2010","publisher":"Nature Publishing Group"}],"id":{"zdb":["2541626-1"],"issn":["2041-4889"],"eki":["620145250"]},"part":{"text":"16(2025), Artikel-ID 619, Seite 1-14","year":"2025","pages":"1-14","volume":"16","extent":"14"},"title":[{"title_sort":"Cell death & disease","title":"Cell death & disease"}],"disp":"Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiationCell death & disease","physDesc":[{"extent":"Online-Ressource"}],"recId":"620145250","note":["Gesehen am 26.02.10"],"titleAlt":[{"title":"Cell death and disease"}],"type":{"bibl":"periodical","media":"Online-Ressource"}}]} | ||
| SRT | |a STAEHLEHANLYSINESPEC1520 | ||