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Feasibility and sensitivity of wearable sensors for daily activity monitoring in spinal cord injury trials

Background - The aim of clinical trials for spinal cord injury (SCI) is to improve everyday-life activity outcomes, which requires reliable methods for monitoring patient activity. This study evaluates sensor-derived activity metrics in comparison to established clinical assessment methods. - Method...

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Main Authors: Giagiozis, Melina (Author) , Lerch, Irina (Author) , Linke, Anita D. (Author) , Jutzeler, Catherine R. (Author) , Rupp, Rüdiger (Author) , Abel, Rainer (Author) , Benito-Penalva, Jesús (Author) , Waldmann, Josina (Author) , Maier, Doris (Author) , Baumberger, Michael (Author) , Kriz, Jiri (Author) , Badke, Andreas (Author) , Hund-Georgiadis, Margret (Author) , Weidner, Norbert (Author) , Demkó, László (Author) , Curt, Armin (Author)
Format: Article (Journal)
Language:English
Published: July 10, 2025
In: Neurorehabilitation and neural repair
Year: 2025, Volume: 39, Issue: 10, Pages: 814-825
ISSN:1552-6844
DOI:10.1177/15459683251352556
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/15459683251352556
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Author Notes:Melina Giagiozis, Msc, Irina Lerch, BSc, Anita D. Linke, MSc, Catherine R. Jutzeler, PhD, Rüdiger Rupp, PhD, Rainer Abel, MD, Jesús Benito-Penalva, MD, Josina Waldmann, MD, Doris Maier, MD, Michael Baumberger, MD, Jiri Kriz, MD, Andreas Badke, MD, Margret Hund-Georgiadis, MD, Norbert Weidner, MD, László Demkó, PhD, and Armin Curt, MD on behalf of the Nogo Inhibition in Spinal Cord Injury Study Group
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Summary:Background - The aim of clinical trials for spinal cord injury (SCI) is to improve everyday-life activity outcomes, which requires reliable methods for monitoring patient activity. This study evaluates sensor-derived activity metrics in comparison to established clinical assessment methods. - Methods - Wearable inertial sensors collected data from 69 individuals with acute, traumatic cervical SCI participating in the Nogo-A Inhibition in Spinal Cord Injury trial (NCT03935321), a phase 2b, multicenter, randomized, placebo-controlled trial. During inpatient rehabilitation, participants wore up to 5 inertial sensors for up to 3 consecutive days each week. An estimation of average daily energy expenditure (EE) was used as an indicator of physical activity and compared to the recovery of Upper Extremity Motor Scores (UEMS) and Spinal Cord Independence Measures (SCIM). - Results - Participants in the verum (n = 41; 59.4%) and placebo (n = 28; 40.6%) groups showed similar initial activity levels, however, the verum group exhibited a significantly greater weekly increase in average daily EE (ΔEE = 11.6 kcal/day/week, 95% CI [1.5, 21.8], P = .025). In contrast, no significant group differences were observed in changes in UEMS (ΔUEMS = 0.1/week, 95% CI [−0.2, 0.3], P = .603) or SCIM (ΔSCIM = 0.2, per week 95% CI [−0.7, 1.1], P = .644). - Conclusion - Continuous sensor-based activity monitoring offers objective and sensitive insights into changes in physical capabilities, effectively complementing periodic clinical assessments. Thus, sensor-derived outcome measures offer potential for improving the evaluation of clinical studies in individuals with SCI. - Clinical Trail Registration: https://clinicaltrials.gov; NCT03935321.
Item Description:Gesehen am 20.01.2026
Physical Description:Online Resource
ISSN:1552-6844
DOI:10.1177/15459683251352556

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