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Large language models-enabled digital twins for precision medicine in rare gynecological tumors

Abstract - - Rare gynecological tumors (RGTs) present major clinical challenges due to their low incidence and heterogeneity. The lack of clear guidelines leads to suboptimal management and poor prognosis. Molecular tumor boards accelerate access to effective therapies by...

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Main Authors: Lammert, Jacqueline (Author) , Pfarr, Nicole (Author) , Kuligin, Leonid (Author) , Mathes, Sonja (Author) , Dreyer, Tobias (Author) , Modersohn, Luise (Author) , Metzger, Patrick (Author) , Ferber, Dyke (Author) , Kather, Jakob Nikolas (Author) , Truhn, Daniel (Author) , Adams, Lisa Christine (Author) , Bressem, Keno Kyrill (Author) , Lange, Sebastian (Author) , Schwamborn, Kristina (Author) , Boeker, Martin (Author) , Kiechle, Marion (Author) , Schatz, Ulrich A. (Author) , Bronger, Holger (Author) , Tschochohei, Maximilian (Author)
Format: Article (Journal)
Language:English
Published: 09 July 2025
In: npj digital medicine
Year: 2025, Volume: 8, Pages: 1-13
ISSN:2398-6352
DOI:10.1038/s41746-025-01810-z
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41746-025-01810-z
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41746-025-01810-z
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Author Notes:Jacqueline Lammert, Nicole Pfarr, Leonid Kuligin, Sonja Mathes, Tobias Dreyer, Luise Modersohn, Patrick Metzger, Dyke Ferber, Jakob Nikolas Kather, Daniel Truhn, Lisa Christine Adams, Keno Kyrill Bressem, Sebastian Lange, Kristina Schwamborn, Martin Boeker, Marion Kiechle, Ulrich A. Schatz, Holger Bronger & Maximilian Tschochohei
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Summary:Abstract - - Rare gynecological tumors (RGTs) present major clinical challenges due to their low incidence and heterogeneity. The lack of clear guidelines leads to suboptimal management and poor prognosis. Molecular tumor boards accelerate access to effective therapies by tailoring treatment based on biomarkers, beyond cancer type. Unstructured data that requires manual curation hinders efficient use of biomarker profiling for therapy matching. This study explores the use of large language models (LLMs) to construct digital twins for precision medicine in RGTs. Our proof-of-concept digital twin system integrates clinical and biomarker data from institutional and published cases ( - n -  = 21) and literature-derived data ( - n -  = 655 publications) to create tailored treatment plans for metastatic uterine carcinosarcoma, identifying options potentially missed by traditional, single-source analysis. LLM-enabled digital twins efficiently model individual patient trajectories. Shifting to a biology-based rather than organ-based tumor definition enables personalized care that could advance RGT management and thus enhance patient outcomes.
Item Description:Gesehen am 20.01.2026
Physical Description:Online Resource
ISSN:2398-6352
DOI:10.1038/s41746-025-01810-z

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