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Damaging intermolecular relaxation processes initiated by heavy-ion irradiation of hydrated biomolecules

Intermolecular Coulombic decay (ICD) is considered a general phenomenon that plays a key role in many fundamental and applied fields related to biological environments. In many cases, however, the mechanisms and efficiency of ICD have yet to be uncovered. A prominent example is heavy-ion cancer ther...

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Main Authors: Gao, Yue (Author) , Skitnevskaya, Anna D. (Author) , Wang, Enliang (Author) , Yuan, Hang (Author) , Ren, Xueguang (Author) , Lin, Hong (Author) , Yan, Zhenyu (Author) , Zhang, Shaofeng (Author) , Gu, Shaofei (Author) , Yang, Bo (Author) , Fang, Feng (Author) , Yan, Shuncheng (Author) , Guo, Dalong (Author) , Zhu, Xiaolong (Author) , Zhao, Dongmei (Author) , Shao, Caojie (Author) , Huang, Zhongkui (Author) , Xue, Xiaorui (Author) , Hao, Xintai (Author) , Zhou, Jiaqi (Author) , Zhang, Tongmin (Author) , Li, Jinyu (Author) , Yan, Xinliang (Author) , Wang, Meng (Author) , Mao, Lijun (Author) , Yin, Dayu (Author) , Tang, Meitang (Author) , Yuan, Youjin (Author) , Yang, Jiancheng (Author) , Trofimov, Alexander B. (Author) , Cederbaum, Lorenz S. (Author) , Kuleff, Alexander I. (Author) , Ma, Xinwen (Author) , Xu, Shenyue (Author)
Format: Article (Journal)
Language:English
Published: 11 March 2025
In: Physical review. X, Expanding access
Year: 2025, Volume: 15, Pages: 1-17
ISSN:2160-3308
DOI:10.1103/PhysRevX.15.011053
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1103/PhysRevX.15.011053
Verlag, kostenfrei, Volltext: https://link.aps.org/doi/10.1103/PhysRevX.15.011053
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Author Notes:Yue Gao, Anna D. Skitnevskaya, Enliang Wang, Hang Yuan, Xueguang Ren, Hong Lin, Zhenyu Yan, Shaofeng Zhang, Shaofei Gu, Bo Yang, Feng Fang, Shuncheng Yan, Dalong Guo, Xiaolong Zhu, Dongmei Zhao, Caojie Shao, Zhongkui Huang, Xiaorui Xue, Xintai Hao, Jiaqi Zhou, Tongmin Zhang, Jinyu Li, Xinliang Yan, Meng Wang, Lijun Mao, Dayu Yin, Meitang Tang, Youjin Yuan, Jiancheng Yang, Alexander B. Trofimov, Lorenz S. Cederbaum, Alexander I. Kuleff, Xinwen Ma, and Shenyue Xu
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Summary:Intermolecular Coulombic decay (ICD) is considered a general phenomenon that plays a key role in many fundamental and applied fields related to biological environments. In many cases, however, the mechanisms and efficiency of ICD have yet to be uncovered. A prominent example is heavy-ion cancer therapy. Here, we report the first detection of a damaging intermolecular relaxation cascade initiated by heavy-ion bombardment of hydrated pyrimidine clusters. The process can significantly contribute to the high biological effectiveness of heavy-ion irradiation and thus might play an essential role in many radiotherapy techniques. Inner-valence ionization of the cluster initiates ICD and triggers proton transfer between water molecules, producing destructive low-energy electrons, HO• radicals, and hydrated protons. Notably, the efficiency of ICD was found to increase dramatically with the number of water molecules, making ICD the dominant decay mechanism after inner-valence ionization. These findings indicate that the biological damage, caused by ICD in aqueous environments, is much more severe than was previously recognized.
Item Description:Gesehen am 20.01.2026
Physical Description:Online Resource
ISSN:2160-3308
DOI:10.1103/PhysRevX.15.011053

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