Non-oxidized PTH (n-oxPTH) is associated with graft loss in kidney transplant recipients
Elevated parathyroid hormone (PTH) concentrations were reported to be associated with chronic renal allograft failure. However, measurements of PTH are challenging, because PTH can occur either as non-oxidized (n-ox) or oxidized (ox) PTH. Only n-ox PTH is a PTH receptor agonist. The intact PTH (iPTH...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2020
|
| In: |
Clinica chimica acta
Year: 2020, Jahrgang: 508, Pages: 92-97 |
| ISSN: | 1873-3492 |
| DOI: | 10.1016/j.cca.2020.05.022 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cca.2020.05.022 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0009898120302199 
|
| Verfasserangaben: | Yong-Ping Lu, Shufei Zeng, Chang Chu, Ahmed A. Hasan, Torsten Slowinski, Liang-Hong Yin, Bernhard K. Krämer, Berthold Hocher |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1949789586 | ||
| 003 | DE-627 | ||
| 005 | 20260120160801.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260120s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.cca.2020.05.022 |2 doi | |
| 035 | |a (DE-627)1949789586 | ||
| 035 | |a (DE-599)KXP1949789586 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lu, YongPing |d 1986- |e VerfasserIn |0 (DE-588)1172671834 |0 (DE-627)1041306210 |0 (DE-576)514710950 |4 aut | |
| 245 | 1 | 0 | |a Non-oxidized PTH (n-oxPTH) is associated with graft loss in kidney transplant recipients |c Yong-Ping Lu, Shufei Zeng, Chang Chu, Ahmed A. Hasan, Torsten Slowinski, Liang-Hong Yin, Bernhard K. Krämer, Berthold Hocher |
| 264 | 1 | |c September 2020 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.01.2026 | ||
| 520 | |a Elevated parathyroid hormone (PTH) concentrations were reported to be associated with chronic renal allograft failure. However, measurements of PTH are challenging, because PTH can occur either as non-oxidized (n-ox) or oxidized (ox) PTH. Only n-ox PTH is a PTH receptor agonist. The intact PTH (iPTH) concentrations measured routinely in clinical practice, however, equals non-oxidized PTH (n-oxPTH) plus oxidized PTH (oxPTH). In CKD patients, the majority of the circulating PTH is oxidized. We measured iPTH, oxPTH and n-oxPTH at study entry in 600 kidney transplant recipients (KTRs). They were followed for graft loss for 3 years. Graft loss was defined as need for initiation of renal replacement therapy. Thirty-eight patients had graft loss during the 3 years follow-up. OxPTH correlated very well with iPTH (R2 = 0.997, p < 0.0001), whereas the correlation between n-oxPTH and iPTH was much weaker (R2 = 0.762, p < 0.0001). Compared to KTRs without graft loss, KTRs with graft loss had significantly higher levels of iPTH, oxPTH, and n-oxPTH (p < 0.0001 in all cases). After adjusting for confounding factors in cox proportional hazards analysis, only n-oxPTH, but not oxPTH neither iPTH, was significantly associated with graft loss (Hazard ratio (HR): 1.02, 95% CI: 1.01-1.03, p = 1.84 × 10−3). The very close correlation between oxPTH and iPTH measurements suggests that conventional iPTH measurements most likely describe oxidative stress rather than PTH bioactivity. Only non-oxidized PTH but not oxidized PTH nor intact PTH is associated with graft loss in stable kidney transplant recipients. | ||
| 650 | 4 | |a Graft failure | |
| 650 | 4 | |a Intact parathyroid hormone | |
| 650 | 4 | |a Kidney transplant recipients | |
| 650 | 4 | |a Non-oxidized parathyroid hormone | |
| 650 | 4 | |a Oxidized parathyroid hormone | |
| 700 | 1 | |a Zeng, Shufei |e VerfasserIn |0 (DE-588)1227728301 |0 (DE-627)174866980X |4 aut | |
| 700 | 1 | |a Chu, Chang |d 1992- |e VerfasserIn |0 (DE-588)119616228X |0 (DE-627)1678018716 |4 aut | |
| 700 | 1 | |a Hasan, Ahmed A. |e VerfasserIn |0 (DE-588)1172932042 |0 (DE-627)1042013187 |0 (DE-576)514901853 |4 aut | |
| 700 | 1 | |a Slowinski, Torsten |d 1969- |e VerfasserIn |0 (DE-588)123391989 |0 (DE-627)706281950 |0 (DE-576)18598620X |4 aut | |
| 700 | 1 | |a Yin, Liang-Hong |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krämer, Bernhard |d 1957- |e VerfasserIn |0 (DE-588)14017589X |0 (DE-627)70358927X |0 (DE-576)314926852 |4 aut | |
| 700 | 1 | |a Hocher, Berthold |d 1962- |e VerfasserIn |0 (DE-588)12000397X |0 (DE-627)696292173 |0 (DE-576)291991033 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinica chimica acta |d Amsterdam [u.a.] : Elsevier Science, 1956 |g 508(2020) vom: Sept., Seite 92-97 |h Online-Ressource |w (DE-627)306654423 |w (DE-600)1499920-1 |w (DE-576)094531242 |x 1873-3492 |7 nnas |a Non-oxidized PTH (n-oxPTH) is associated with graft loss in kidney transplant recipients |
| 773 | 1 | 8 | |g volume:508 |g year:2020 |g month:09 |g pages:92-97 |g extent:6 |a Non-oxidized PTH (n-oxPTH) is associated with graft loss in kidney transplant recipients |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.cca.2020.05.022 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |7 1 |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0009898120302199 |x Verlag |z lizenzpflichtig |3 Volltext |7 1 |
| 951 | |a AR | ||
| 992 | |a 20260120 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 12000397X |a Hocher, Berthold |m 12000397X:Hocher, Berthold |d 60000 |d 61400 |d 60000 |e 60000PH12000397X |e 61400PH12000397X |e 60000PH12000397X |k 0/60000/ |k 1/60000/61400/ |k 0/60000/ |p 8 |y j | ||
| 998 | |g 14017589X |a Krämer, Bernhard |m 14017589X:Krämer, Bernhard |d 60000 |d 61400 |e 60000PK14017589X |e 61400PK14017589X |k 0/60000/ |k 1/60000/61400/ |p 7 | ||
| 998 | |g 1172932042 |a Hasan, Ahmed A. |m 1172932042:Hasan, Ahmed A. |d 60000 |d 61400 |e 60000PH1172932042 |e 61400PH1172932042 |k 0/60000/ |k 1/60000/61400/ |p 4 | ||
| 998 | |g 119616228X |a Chu, Chang |m 119616228X:Chu, Chang |d 60000 |d 61400 |e 60000PC119616228X |e 61400PC119616228X |k 0/60000/ |k 1/60000/61400/ |p 3 | ||
| 998 | |g 1227728301 |a Zeng, Shufei |m 1227728301:Zeng, Shufei |d 60000 |d 61400 |e 60000PZ1227728301 |e 61400PZ1227728301 |k 0/60000/ |k 1/60000/61400/ |p 2 | ||
| 998 | |g 1172671834 |a Lu, Yong-Ping |m 1172671834:Lu, Yong-Ping |d 60000 |d 61400 |e 60000PL1172671834 |e 61400PL1172671834 |k 0/60000/ |k 1/60000/61400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1949789586 |e 4855198528 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"YongPing","role":"aut","display":"Lu, YongPing","family":"Lu"},{"role":"aut","given":"Shufei","display":"Zeng, Shufei","family":"Zeng"},{"display":"Chu, Chang","family":"Chu","role":"aut","given":"Chang"},{"display":"Hasan, Ahmed A.","family":"Hasan","role":"aut","given":"Ahmed A."},{"given":"Torsten","role":"aut","family":"Slowinski","display":"Slowinski, Torsten"},{"family":"Yin","display":"Yin, Liang-Hong","role":"aut","given":"Liang-Hong"},{"role":"aut","given":"Bernhard","family":"Krämer","display":"Krämer, Bernhard"},{"role":"aut","given":"Berthold","family":"Hocher","display":"Hocher, Berthold"}],"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"September 2020"}],"note":["Gesehen am 20.01.2026"],"title":[{"title_sort":"Non-oxidized PTH (n-oxPTH) is associated with graft loss in kidney transplant recipients","title":"Non-oxidized PTH (n-oxPTH) is associated with graft loss in kidney transplant recipients"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"physDesc":[{"extent":"6 S."}],"name":{"displayForm":["Yong-Ping Lu, Shufei Zeng, Chang Chu, Ahmed A. Hasan, Torsten Slowinski, Liang-Hong Yin, Bernhard K. Krämer, Berthold Hocher"]},"recId":"1949789586","id":{"eki":["1949789586"],"doi":["10.1016/j.cca.2020.05.022"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"recId":"306654423","pubHistory":["1.1956 -"],"id":{"eki":["306654423"],"issn":["1873-3492"],"zdb":["1499920-1"]},"disp":"Non-oxidized PTH (n-oxPTH) is associated with graft loss in kidney transplant recipientsClinica chimica acta","part":{"volume":"508","extent":"6","pages":"92-97","text":"508(2020) vom: Sept., Seite 92-97","year":"2020"},"note":["Gesehen am 04.02.20"],"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"1956-","publisher":"Elsevier Science","dateIssuedKey":"1956"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"Clinica chimica acta","subtitle":"international journal of clinical chemistry and applied molecular biology","title":"Clinica chimica acta"}],"language":["eng"]}]} | ||
| SRT | |a LUYONGPINGNONOXIDIZE2020 | ||