Risk-adjusted screening for prostate cancer: defining the low-risk group by data from the PROBASE trial
Background - Risk-adjusted screening for prostate cancer (PCa) aims to reduce harms by less frequent retesting, especially in men at a low risk of PCa. Definitions of low risk are based mainly on studies in men starting screening at age 55-60 yr. - Objective - To identify men at age 45 yr with a low...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 2024
|
| In: |
European urology
Year: 2024, Jahrgang: 86, Heft: 6, Pages: 493-500 |
| ISSN: | 1873-7560 |
| DOI: | 10.1016/j.eururo.2024.04.030 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.eururo.2024.04.030 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0302283824023583 
|
| Verfasserangaben: | Agne Krilaviciute, Rudolf Kaaks, Petra Seibold, Maxime de Vrieze, Jale Lakes, Jan Philipp Radtke, Markus Kuczyk, Nina N. Harke, Jürgen Debus, Christoph A. Fink, Kathleen Herkommer, Jürgen E. Gschwend, Valentin H. Meissner, Axel Benner, Glen Kristiansen, Boris Hadaschik, Christian Arsov, Lars Schimmöller, Gerald Antoch, Frederik L. Giesel, Marcus Makowski, Frank Wacker, Heinz-Peter Schlemmer, Nikolaus Becker, Peter Albers |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1949893464 | ||
| 003 | DE-627 | ||
| 005 | 20260121134759.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260121s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.eururo.2024.04.030 |2 doi | |
| 035 | |a (DE-627)1949893464 | ||
| 035 | |a (DE-599)KXP1949893464 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Krilaviciute, Agne |d 1988- |e VerfasserIn |0 (DE-588)1141206986 |0 (DE-627)898965772 |0 (DE-576)415191602 |4 aut | |
| 245 | 1 | 0 | |a Risk-adjusted screening for prostate cancer |b defining the low-risk group by data from the PROBASE trial |c Agne Krilaviciute, Rudolf Kaaks, Petra Seibold, Maxime de Vrieze, Jale Lakes, Jan Philipp Radtke, Markus Kuczyk, Nina N. Harke, Jürgen Debus, Christoph A. Fink, Kathleen Herkommer, Jürgen E. Gschwend, Valentin H. Meissner, Axel Benner, Glen Kristiansen, Boris Hadaschik, Christian Arsov, Lars Schimmöller, Gerald Antoch, Frederik L. Giesel, Marcus Makowski, Frank Wacker, Heinz-Peter Schlemmer, Nikolaus Becker, Peter Albers |
| 264 | 1 | |c December 2024 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.01.2026 | ||
| 500 | |a Online veröffentlicht: 15. Mai 2024 | ||
| 520 | |a Background - Risk-adjusted screening for prostate cancer (PCa) aims to reduce harms by less frequent retesting, especially in men at a low risk of PCa. Definitions of low risk are based mainly on studies in men starting screening at age 55-60 yr. - Objective - To identify men at age 45 yr with a low risk of PCa. - Design, setting, and participants - A population-based, risk-adjusted PCa screening trial was conducted in Germany using baseline prostate-specific antigen (PSA) starting in young men (PROBASE). - Intervention - PSA measurements starting at the age of 45 yr. - Outcome measurements and statistical analysis - The incidence of PCa within 5 yr was assessed in men with screen-negative baseline PSA <1.5 ng/ml compared with those with PSA 1.5-≤3.0 ng/ml. - Results and limitations - Of 23301 men who received a first PSA test at age 45 yr, 0.79% had a screen-positive PSA value of ≥3 ng/ml. Among the 89% of men who had a screen-negative baseline PSA value of <1.5 ng/ml, only 0.45% received a positive PSA test ≥3 ng/ml upon retesting after 5 yr. By contrast, for those with a screen-negative baseline PSA value of 1.5-3 ng/ml, 13% surpassed 3 ng/ml upon biennial testing within the next 4 yr. The incidence of PCa in subsequent screening rounds increased with increasing baseline PSA levels, from 0.13 per 1000 person-years for men with initial PSA level of <1.5 ng/ml to 8.0 per 1000 person-years for those with PSA levels of 1.5-3.0 ng/ml. A limitation is a follow-up time of only 5 yr, so far. - Conclusions - Men with baseline PSA <1.5 ng/ml at age 45 yr are at a very low risk of PCa over the next 5 yr. - Patient summary - The PROBASE study showed that men with baseline prostate-specific antigen (PSA) <1.5 ng/ml at age 45 yr have a very low prostate cancer detection rate over 5 yr and do not need PSA retesting during this time. | ||
| 650 | 4 | |a Low risk | |
| 650 | 4 | |a Prostate cancer | |
| 650 | 4 | |a Prostate-specific antigen | |
| 650 | 4 | |a Screening | |
| 700 | 1 | |a Kaaks, Rudolf |d 1960- |e VerfasserIn |0 (DE-588)172809223 |0 (DE-627)697739562 |0 (DE-576)133665518 |4 aut | |
| 700 | 1 | |a Seibold, Petra Beate |d 1981- |e VerfasserIn |0 (DE-588)1022470523 |0 (DE-627)71698962X |0 (DE-576)362814635 |4 aut | |
| 700 | 1 | |a De Vrieze, Maxime |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lakes, Jale |e VerfasserIn |0 (DE-588)1250384745 |0 (DE-627)1787243362 |4 aut | |
| 700 | 1 | |a Radtke, Jan Philipp |d 1985- |e VerfasserIn |0 (DE-588)1020328290 |0 (DE-627)688118089 |0 (DE-576)360178170 |4 aut | |
| 700 | 1 | |a Kuczyk, Markus A. |d 1962- |e VerfasserIn |0 (DE-588)13034009X |0 (DE-627)498502880 |0 (DE-576)298137127 |4 aut | |
| 700 | 1 | |a Harke, Nina Natascha |d 1982- |e VerfasserIn |0 (DE-588)1012784142 |0 (DE-627)662732596 |0 (DE-576)345934202 |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 700 | 1 | |a Fink, Christoph Andreas |d 1992- |e VerfasserIn |0 (DE-588)1163354759 |0 (DE-627)1027642225 |0 (DE-576)507933028 |4 aut | |
| 700 | 1 | |a Herkommer, Kathleen |e VerfasserIn |0 (DE-588)114636435 |0 (DE-627)618892753 |0 (DE-576)318285398 |4 aut | |
| 700 | 1 | |a Gschwend, Jürgen E. |d 1962- |e VerfasserIn |0 (DE-588)111741300 |0 (DE-627)523317697 |0 (DE-576)178294446 |4 aut | |
| 700 | 1 | |a Meissner, Valentin H. |d 1990- |e VerfasserIn |0 (DE-588)1201168279 |0 (DE-627)1684637775 |4 aut | |
| 700 | 1 | |a Benner, Axel |d 1959- |e VerfasserIn |0 (DE-588)106584686X |0 (DE-627)81687221X |0 (DE-576)425536602 |4 aut | |
| 700 | 1 | |a Kristiansen, Glen |d 1969- |e VerfasserIn |0 (DE-588)122243013 |0 (DE-627)081824084 |0 (DE-576)293169616 |4 aut | |
| 700 | 1 | |a Hadaschik, Boris |d 1974- |e VerfasserIn |0 (DE-588)124300553 |0 (DE-627)085770930 |0 (DE-576)294109013 |4 aut | |
| 700 | 1 | |a Arsov, Christian |d 1976- |e VerfasserIn |0 (DE-588)133016307 |0 (DE-627)530932482 |0 (DE-576)299566439 |4 aut | |
| 700 | 1 | |a Schimmöller, Lars |d 1979- |e VerfasserIn |0 (DE-588)102371812X |0 (DE-627)718431065 |0 (DE-576)367313197 |4 aut | |
| 700 | 1 | |a Antoch, Gerald |d 1971- |e VerfasserIn |0 (DE-588)122370406 |0 (DE-627)08190424X |0 (DE-576)29324121X |4 aut | |
| 700 | 1 | |a Giesel, Frederik L. |d 1970- |e VerfasserIn |0 (DE-588)129031240 |0 (DE-627)387883878 |0 (DE-576)297457071 |4 aut | |
| 700 | 1 | |a Makowski, Marcus Richard |d 1980- |e VerfasserIn |0 (DE-588)133057836 |0 (DE-627)533310962 |0 (DE-576)299594289 |4 aut | |
| 700 | 1 | |a Wacker, Frank |e VerfasserIn |0 (DE-588)1019957336 |0 (DE-627)685798674 |0 (DE-576)359231675 |4 aut | |
| 700 | 1 | |a Schlemmer, Heinz-Peter |d 1961- |e VerfasserIn |0 (DE-588)1025559967 |0 (DE-627)722927142 |0 (DE-576)17334805X |4 aut | |
| 700 | 1 | |a Becker, Nikolaus |d 1950- |e VerfasserIn |0 (DE-588)124780962 |0 (DE-627)706711084 |0 (DE-576)186605765 |4 aut | |
| 700 | 1 | |a Albers, Peter |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European urology |d Amsterdam [u.a.] : Elsevier Science, 1976 |g 86(2024), 6, Seite 493-500 |h Online-Ressource |w (DE-627)300191596 |w (DE-600)1482253-2 |w (DE-576)099718103 |x 1873-7560 |7 nnas |a Risk-adjusted screening for prostate cancer defining the low-risk group by data from the PROBASE trial |
| 773 | 1 | 8 | |g volume:86 |g year:2024 |g number:6 |g pages:493-500 |g extent:8 |a Risk-adjusted screening for prostate cancer defining the low-risk group by data from the PROBASE trial |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.eururo.2024.04.030 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0302283824023583 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20260121 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 124780962 |a Becker, Nikolaus |m 124780962:Becker, Nikolaus |d 50000 |e 50000PB124780962 |k 0/50000/ |p 24 | ||
| 998 | |g 1025559967 |a Schlemmer, Heinz-Peter |m 1025559967:Schlemmer, Heinz-Peter |d 50000 |e 50000PS1025559967 |k 0/50000/ |p 23 | ||
| 998 | |g 106584686X |a Benner, Axel |m 106584686X:Benner, Axel |d 50000 |e 50000PB106584686X |k 0/50000/ |p 14 | ||
| 998 | |g 1163354759 |a Fink, Christoph Andreas |m 1163354759:Fink, Christoph Andreas |d 910000 |d 911400 |e 910000PF1163354759 |e 911400PF1163354759 |k 0/910000/ |k 1/910000/911400/ |p 10 | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |e 910000PD1022671421 |e 911400PD1022671421 |k 0/910000/ |k 1/910000/911400/ |p 9 | ||
| 998 | |g 1022470523 |a Seibold, Petra Beate |m 1022470523:Seibold, Petra Beate |p 3 | ||
| 998 | |g 172809223 |a Kaaks, Rudolf |m 172809223:Kaaks, Rudolf |d 50000 |e 50000PK172809223 |k 0/50000/ |p 2 | ||
| 998 | |g 1141206986 |a Krilaviciute, Agne |m 1141206986:Krilaviciute, Agne |p 1 |x j | ||
| 999 | |a KXP-PPN1949893464 |e 4856122215 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1949893464"],"doi":["10.1016/j.eururo.2024.04.030"]},"physDesc":[{"extent":"8 S."}],"title":[{"title_sort":"Risk-adjusted screening for prostate cancer","subtitle":"defining the low-risk group by data from the PROBASE trial","title":"Risk-adjusted screening for prostate cancer"}],"person":[{"family":"Krilaviciute","role":"aut","given":"Agne","display":"Krilaviciute, Agne"},{"display":"Kaaks, Rudolf","given":"Rudolf","role":"aut","family":"Kaaks"},{"given":"Petra Beate","display":"Seibold, Petra Beate","role":"aut","family":"Seibold"},{"role":"aut","display":"De Vrieze, Maxime","given":"Maxime","family":"De Vrieze"},{"role":"aut","given":"Jale","display":"Lakes, Jale","family":"Lakes"},{"family":"Radtke","role":"aut","given":"Jan Philipp","display":"Radtke, Jan Philipp"},{"family":"Kuczyk","role":"aut","given":"Markus A.","display":"Kuczyk, Markus A."},{"role":"aut","display":"Harke, Nina Natascha","given":"Nina Natascha","family":"Harke"},{"family":"Debus","given":"Jürgen","display":"Debus, Jürgen","role":"aut"},{"role":"aut","given":"Christoph Andreas","display":"Fink, Christoph Andreas","family":"Fink"},{"role":"aut","display":"Herkommer, Kathleen","given":"Kathleen","family":"Herkommer"},{"family":"Gschwend","display":"Gschwend, Jürgen E.","given":"Jürgen E.","role":"aut"},{"display":"Meissner, Valentin H.","given":"Valentin H.","role":"aut","family":"Meissner"},{"family":"Benner","role":"aut","given":"Axel","display":"Benner, Axel"},{"role":"aut","display":"Kristiansen, Glen","given":"Glen","family":"Kristiansen"},{"family":"Hadaschik","given":"Boris","display":"Hadaschik, Boris","role":"aut"},{"family":"Arsov","role":"aut","given":"Christian","display":"Arsov, Christian"},{"family":"Schimmöller","role":"aut","display":"Schimmöller, Lars","given":"Lars"},{"family":"Antoch","role":"aut","given":"Gerald","display":"Antoch, Gerald"},{"given":"Frederik L.","display":"Giesel, Frederik L.","role":"aut","family":"Giesel"},{"family":"Makowski","role":"aut","display":"Makowski, Marcus Richard","given":"Marcus Richard"},{"given":"Frank","display":"Wacker, Frank","role":"aut","family":"Wacker"},{"display":"Schlemmer, Heinz-Peter","given":"Heinz-Peter","role":"aut","family":"Schlemmer"},{"role":"aut","given":"Nikolaus","display":"Becker, Nikolaus","family":"Becker"},{"family":"Albers","given":"Peter","display":"Albers, Peter","role":"aut"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Agne Krilaviciute, Rudolf Kaaks, Petra Seibold, Maxime de Vrieze, Jale Lakes, Jan Philipp Radtke, Markus Kuczyk, Nina N. Harke, Jürgen Debus, Christoph A. Fink, Kathleen Herkommer, Jürgen E. Gschwend, Valentin H. Meissner, Axel Benner, Glen Kristiansen, Boris Hadaschik, Christian Arsov, Lars Schimmöller, Gerald Antoch, Frederik L. Giesel, Marcus Makowski, Frank Wacker, Heinz-Peter Schlemmer, Nikolaus Becker, Peter Albers"]},"language":["eng"],"relHost":[{"part":{"pages":"493-500","year":"2024","text":"86(2024), 6, Seite 493-500","extent":"8","volume":"86","issue":"6"},"title":[{"title_sort":"European urology","subtitle":"official organ of the European Association of Urology, the European Organization for Research and Treatment of Cancer - Genito-Urinary Group, the European Society for Urological Oncology and Endocrinology","title":"European urology"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Risk-adjusted screening for prostate cancer defining the low-risk group by data from the PROBASE trialEuropean urology","type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"300191596","note":["Ungezählte Beil. bis 40.2001: Supplement"],"origin":[{"publisherPlace":"Amsterdam [u.a.] ; Basel","dateIssuedKey":"1976","publisher":"Elsevier Science ; Karger","dateIssuedDisp":"1976-"}],"pubHistory":["Nachgewiesen 2.1976 -"],"id":{"issn":["1873-7560","1421-993X"],"eki":["300191596"],"zdb":["1482253-2"]},"language":["eng"]}],"recId":"1949893464","origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"December 2024"}],"note":["Gesehen am 21.01.2026","Online veröffentlicht: 15. Mai 2024"]} | ||
| SRT | |a KRILAVICIURISKADJUST2024 | ||