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Optimising T-cell immunotherapy in patients with multiple myeloma: practical considerations from the European Myeloma Network

Novel T-cell immunotherapies (chimeric antigen receptor [CAR] T cells and T-cell redirecting bispecific antibodies) are changing the treatment landscape of relapsed or refractory multiple myeloma. In this Review, the European Myeloma Network provides recommendations to optimise both safety and effic...

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Hauptverfasser: Donk, Niels van de (VerfasserIn) , Moreau, Philippe (VerfasserIn) , San-Miguel, Jesús F (VerfasserIn) , Mateos, Maria-Victoria (VerfasserIn) , Dimopoulos, Meletios A (VerfasserIn) , Zweegman, Sonja (VerfasserIn) , Gay, Francesca (VerfasserIn) , Engelhardt, Monika (VerfasserIn) , Mina, Roberto (VerfasserIn) , Zamagni, Elena (VerfasserIn) , Delforge, Michel (VerfasserIn) , Beksac, Meral (VerfasserIn) , Spencer, Andrew (VerfasserIn) , Schjesvold, Fredrik (VerfasserIn) , Driessen, Christoph (VerfasserIn) , Kaiser, Martin (VerfasserIn) , Perrot, Aurore (VerfasserIn) , Wäsch, Ralph (VerfasserIn) , Korst, Charlotte LBM (VerfasserIn) , Broijl, Annemiek (VerfasserIn) , Touzeau, Cyrille (VerfasserIn) , Manier, Salomon (VerfasserIn) , Hajek, Roman (VerfasserIn) , Ludwig, Heinz (VerfasserIn) , Fernandez de Larrea, Carlos (VerfasserIn) , Popat, Rakesh (VerfasserIn) , Musto, Pellegrino (VerfasserIn) , Rodriguez-Otero, Paula (VerfasserIn) , Yong, Kwee (VerfasserIn) , Rasche, Leo (VerfasserIn) , Terpos, Evangelos (VerfasserIn) , Raab, Marc-Steffen (VerfasserIn) , Boccadoro, Mario (VerfasserIn) , Sonneveld, Pieter (VerfasserIn) , Einsele, Hermann (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: August 2025
In: The lancet. Haematology
Year: 2025, Jahrgang: 12, Heft: 8, Pages: e635-e649
ISSN:2352-3026
DOI:10.1016/S2352-3026(25)00117-6
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S2352-3026(25)00117-6
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2352302625001176
Volltext
Verfasserangaben:Niels WCJ van de Donk, Philippe Moreau, Jesús F San-Miguel, Maria-Victoria Mateos, Meletios A Dimopoulos, Sonja Zweegman, Francesca Gay, Monika Engelhardt, Roberto Mina, Elena Zamagni, Michel Delforge, Meral Beksac, Andrew Spencer, Fredrik Schjesvold, Christoph Driessen, Martin Kaiser, Aurore Perrot, Ralph Wäsch, Charlotte LBM Korst, Annemiek Broijl, Cyrille Touzeau, Salomon Manier, Roman Hajek, Heinz Ludwig, Carlos Fernandez de Larrea, Rakesh Popat, Pellegrino Musto, Paula Rodriguez-Otero, Kwee Yong, Leo Rasche, Evangelos Terpos, Marc S Raab, Mario Boccadoro, Pieter Sonneveld, Hermann Einsele, on behalf of the EMN Guidelines Committee
Beschreibung
Zusammenfassung:Novel T-cell immunotherapies (chimeric antigen receptor [CAR] T cells and T-cell redirecting bispecific antibodies) are changing the treatment landscape of relapsed or refractory multiple myeloma. In this Review, the European Myeloma Network provides recommendations to optimise both safety and efficacy of T-cell immunotherapy. In patients who are eligible for both CAR T-cell therapy and bispecific antibodies, we recommend using CAR T-cell therapy first due to the high response rate and durable progression-free survival, accompanied by improved quality of life. Furthermore, previous bispecific antibody treatment has a negative effect on the efficacy of CAR T-cell therapy, and there is emerging evidence that suggests that relapse after B-cell maturation antigen-directed CAR T-cell therapy can be effectively managed with bispecific antibodies. Timely referral and planning are crucial before initiating T-cell immunotherapy to optimise treatment selection, conduct adequate diagnostic tests (eg, excluding latent infections), and identify modifiable risk factors to improve clinical outcomes. Supportive care is crucial in all patients receiving T-cell immunotherapy to prevent non-relapse mortality.
Beschreibung:Online verfügbar: 25. Juni 2025, Artikelversion: 4. August 2025
Gesehen am 22.01.2026
Beschreibung:Online Resource
ISSN:2352-3026
DOI:10.1016/S2352-3026(25)00117-6

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