Microbial metabolites shape mammalian protein translation: spotlight
Eukaryotic queuosine tRNA modification depends on the intake of microbial queuine. In a recent issue of Nature Cell Biology, Zhang et al. show that pre-queuosine 1 (preQ1), an intermediate of the bacterial queuine biosynthesis pathway, competes with queuine for the same mammalian tRNA targets to ant...
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| Main Authors: | , |
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
December, 2 2025
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| In: |
Cell metabolism
Year: 2025, Volume: 37, Issue: 12, Pages: 2301-2302 |
| ISSN: | 1932-7420 |
| DOI: | 10.1016/j.cmet.2025.11.003 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cmet.2025.11.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1550413125004875 
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| Author Notes: | Francesca Tuorto and Frank Lyko |
| Summary: | Eukaryotic queuosine tRNA modification depends on the intake of microbial queuine. In a recent issue of Nature Cell Biology, Zhang et al. show that pre-queuosine 1 (preQ1), an intermediate of the bacterial queuine biosynthesis pathway, competes with queuine for the same mammalian tRNA targets to antagonistically modulate protein translation and cell proliferation. |
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| Item Description: | Online verfügbar: 2. Dezember 2025, Artikelversion: 2. Dezember 2025 Gesehen am 22.01.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1932-7420 |
| DOI: | 10.1016/j.cmet.2025.11.003 |