Microbial metabolites shape mammalian protein translation: spotlight
Eukaryotic queuosine tRNA modification depends on the intake of microbial queuine. In a recent issue of Nature Cell Biology, Zhang et al. show that pre-queuosine 1 (preQ1), an intermediate of the bacterial queuine biosynthesis pathway, competes with queuine for the same mammalian tRNA targets to ant...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
December, 2 2025
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| In: |
Cell metabolism
Year: 2025, Jahrgang: 37, Heft: 12, Pages: 2301-2302 |
| ISSN: | 1932-7420 |
| DOI: | 10.1016/j.cmet.2025.11.003 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cmet.2025.11.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1550413125004875 
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| Verfasserangaben: | Francesca Tuorto and Frank Lyko |
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| 520 | |a Eukaryotic queuosine tRNA modification depends on the intake of microbial queuine. In a recent issue of Nature Cell Biology, Zhang et al. show that pre-queuosine 1 (preQ1), an intermediate of the bacterial queuine biosynthesis pathway, competes with queuine for the same mammalian tRNA targets to antagonistically modulate protein translation and cell proliferation. | ||
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| 787 | 0 | 8 | |i Ergänzung zu |a Zhang, Wen et al. |t Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control, in: Nature Cell Biology |d 2025 |g Vol. 27(10), 1812-1826 |o 10.1038/s41556-025-01750-6 |
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