Microbial metabolites shape mammalian protein translation: spotlight
Eukaryotic queuosine tRNA modification depends on the intake of microbial queuine. In a recent issue of Nature Cell Biology, Zhang et al. show that pre-queuosine 1 (preQ1), an intermediate of the bacterial queuine biosynthesis pathway, competes with queuine for the same mammalian tRNA targets to ant...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
December, 2 2025
|
| In: |
Cell metabolism
Year: 2025, Jahrgang: 37, Heft: 12, Pages: 2301-2302 |
| ISSN: | 1932-7420 |
| DOI: | 10.1016/j.cmet.2025.11.003 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cmet.2025.11.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1550413125004875 
|
| Verfasserangaben: | Francesca Tuorto and Frank Lyko |
| Zusammenfassung: | Eukaryotic queuosine tRNA modification depends on the intake of microbial queuine. In a recent issue of Nature Cell Biology, Zhang et al. show that pre-queuosine 1 (preQ1), an intermediate of the bacterial queuine biosynthesis pathway, competes with queuine for the same mammalian tRNA targets to antagonistically modulate protein translation and cell proliferation. |
|---|---|
| Beschreibung: | Online verfügbar: 2. Dezember 2025, Artikelversion: 2. Dezember 2025 Gesehen am 22.01.2026 |
| Beschreibung: | Online Resource |
| ISSN: | 1932-7420 |
| DOI: | 10.1016/j.cmet.2025.11.003 |