Remote control of AMPK via extracellular adenosine controls tissue growth
Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a regulator of cellular catabolism that is activated by AMP. As AMP accumulates in cells with low ATP, AMPK is considered a stress-activated kinase. While studying organ growth during Drosophila development, we find that AMPK can also...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
Oct 2025
|
| In: |
Nature cell biology
Year: 2025, Jahrgang: 27, Heft: 10, Pages: 1827-1837 |
| ISSN: | 1476-4679 |
| DOI: | 10.1038/s41556-025-01764-0 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41556-025-01764-0 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41556-025-01764-0 
|
| Verfasserangaben: | Yao Zhang, Katrin Strassburger & Aurelio A. Teleman |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1950181278 | ||
| 003 | DE-627 | ||
| 005 | 20260126103654.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260126s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41556-025-01764-0 |2 doi | |
| 035 | |a (DE-627)1950181278 | ||
| 035 | |a (DE-599)KXP1950181278 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Zhang, Yao |e VerfasserIn |0 (DE-588)1387970194 |0 (DE-627)1950183165 |4 aut | |
| 245 | 1 | 0 | |a Remote control of AMPK via extracellular adenosine controls tissue growth |c Yao Zhang, Katrin Strassburger & Aurelio A. Teleman |
| 264 | 1 | |c Oct 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 28 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht am 26. September 2025 | ||
| 500 | |a Gesehen am 26.01.2026 | ||
| 520 | |a Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a regulator of cellular catabolism that is activated by AMP. As AMP accumulates in cells with low ATP, AMPK is considered a stress-activated kinase. While studying organ growth during Drosophila development, we find that AMPK can also be activated by a signalling metabolite not related to stress. Specifically, we find that two physiological inputs known to regulate organ growth rates (ecdysone (a steroid hormone) and dietary protein) modulate expression of adenosine deaminase in the intestine. This, in turn, alters circulating adenosine levels. Circulating adenosine acts as a signalling molecule by entering cells, becoming phosphorylated to AMP and activating AMPK to inhibit organ growth. Thus, AMPK activity is regulated developmentally, and AMPK activity in one tissue can be remote controlled by another tissue via circulating adenosine. Notably, this mechanism accounts for half the effect of dietary protein on tissue growth rates in Drosophila. | ||
| 650 | 4 | |a Cell growth | |
| 650 | 4 | |a Cell signalling | |
| 650 | 4 | |a Drosophila | |
| 700 | 1 | |a Straßburger, Katrin |e VerfasserIn |0 (DE-588)1249417104 |0 (DE-627)178595721X |4 aut | |
| 700 | 1 | |a Teleman, Aurelio A. |d 1976- |e VerfasserIn |0 (DE-588)1155118294 |0 (DE-627)1016370121 |0 (DE-576)501431861 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature cell biology |d New York, NY : Nature America, 1999 |g 27(2025), 10 vom: Okt., Seite 1827-1837 |h Online-Ressource |w (DE-627)303393726 |w (DE-600)1494945-3 |w (DE-576)08088718X |x 1476-4679 |7 nnas |a Remote control of AMPK via extracellular adenosine controls tissue growth |
| 773 | 1 | 8 | |g volume:27 |g year:2025 |g number:10 |g month:10 |g pages:1827-1837 |g extent:28 |a Remote control of AMPK via extracellular adenosine controls tissue growth |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41556-025-01764-0 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41556-025-01764-0 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20260126 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1155118294 |a Teleman, Aurelio A. |m 1155118294:Teleman, Aurelio A. |d 700000 |d 721000 |e 700000PT1155118294 |e 721000PT1155118294 |k 0/700000/ |k 1/700000/721000/ |p 3 |y j | ||
| 999 | |a KXP-PPN1950181278 |e 4860258207 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1038/s41556-025-01764-0"],"eki":["1950181278"]},"relHost":[{"part":{"year":"2025","pages":"1827-1837","text":"27(2025), 10 vom: Okt., Seite 1827-1837","extent":"28","volume":"27","issue":"10"},"origin":[{"dateIssuedDisp":"1999-","publisherPlace":"New York, NY","dateIssuedKey":"1999","publisher":"Nature America"}],"note":["Gesehen am 02.03.05"],"title":[{"title_sort":"Nature cell biology","title":"Nature cell biology"}],"titleAlt":[{"title":"Cell biology"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"disp":"Remote control of AMPK via extracellular adenosine controls tissue growthNature cell biology","id":{"zdb":["1494945-3"],"eki":["303393726"],"issn":["1476-4679"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"303393726","pubHistory":["1.1999 -"]}],"physDesc":[{"noteIll":"Illustrationen","extent":"28 S."}],"name":{"displayForm":["Yao Zhang, Katrin Strassburger & Aurelio A. Teleman"]},"recId":"1950181278","origin":[{"dateIssuedDisp":"Oct 2025","dateIssuedKey":"2025"}],"note":["Online veröffentlicht am 26. September 2025","Gesehen am 26.01.2026"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Remote control of AMPK via extracellular adenosine controls tissue growth","title":"Remote control of AMPK via extracellular adenosine controls tissue growth"}],"language":["eng"],"person":[{"role":"aut","given":"Yao","display":"Zhang, Yao","family":"Zhang"},{"role":"aut","given":"Katrin","display":"Straßburger, Katrin","family":"Straßburger"},{"display":"Teleman, Aurelio A.","family":"Teleman","role":"aut","given":"Aurelio A."}]} | ||
| SRT | |a ZHANGYAOSTREMOTECONT2025 | ||