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Real-world evidence: better than nothing or the future?: A perspective on clinical evidence generation in interventional oncology

Randomised controlled trials (RCTs) have traditionally been regarded as the gold standard in evidence-based medicine, providing a high level of evidence. However, mounting complexities, ranging from ethical issues and logistical barriers to rapid technological evolutions, have sparked interest in al...

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Bibliographic Details
Main Authors: Kaufmann, Nathalie (Author) , Pereira, Philippe L. (Author)
Format: Article (Journal)
Language:English
Published: 25 September 2025
In: CardioVascular and interventional radiology
Year: 2025, Pages: 1-8
ISSN:1432-086X
DOI:10.1007/s00270-025-04179-4
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00270-025-04179-4
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00270-025-04179-4
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Author Notes:Nathalie C. Kaufmann, Philippe L. Pereira
Description
Summary:Randomised controlled trials (RCTs) have traditionally been regarded as the gold standard in evidence-based medicine, providing a high level of evidence. However, mounting complexities, ranging from ethical issues and logistical barriers to rapid technological evolutions, have sparked interest in alternative or complementary evidence-generation methods. Real-world evidence (RWE) from large, well-designed research projects is increasingly viewed as powerful tools. Although RWE is sometimes perceived as “less robust” compared to RCTs due to potential biases, recent advances in study design, data capture, and analytical frameworks have highlighted its potential for shaping clinical practice and informing regulatory decisions. This article discusses the benefits and challenges of RWE within interventional oncology and explores whether it is merely “better than nothing” or indeed represents a key pillar of the future of clinical research.
Item Description:Gesehen am 27.01.2026
Physical Description:Online Resource
ISSN:1432-086X
DOI:10.1007/s00270-025-04179-4

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