Analysis of anatomical location, mitoses, and Ki-67 in 2608 meningiomas
Ki-67 proliferation index (PI) and mitoses are frequent histopathological proliferation markers in meningioma diagnostics. They are used extensively in grading, with mitotic count constituting the major grading criterion in meningiomas but their mutual correlations and associations with phenotypic c...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 November 2025
|
| In: |
Journal of neuropathology and experimental neurology
Year: 2025, Pages: 1-14 |
| ISSN: | 1554-6578 |
| DOI: | 10.1093/jnen/nlaf131 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/jnen/nlaf131
|
| Verfasserangaben: | Anders Broechner, MD, Andrea Daniela Maier, MD, PhD, Christian Mirian, MD, PhD, Felix Sahm, Prof., Dr Med, Stefan Hamelmann, PhD, Miriam Ratliff, MD, Nima Etminan, Prof., Dr Med, Christel Herold-Mende, Prof., Dr Med, Sandro Krieg, Prof., Dr Med, Andreas von Deimling, MD, Sybren L.N. Maas, MD, PhD, Eelke M. Bos, MD, PhD, Tiit Mathiesen, Prof., Dr Med |
MARC
| LEADER | 00000naa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1950496384 | ||
| 003 | DE-627 | ||
| 005 | 20260128125602.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260128s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/jnen/nlaf131 |2 doi | |
| 035 | |a (DE-627)1950496384 | ||
| 035 | |a (DE-599)KXP1950496384 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Broechner, Anders |e VerfasserIn |0 (DE-588)1388222051 |0 (DE-627)1950496937 |4 aut | |
| 245 | 1 | 0 | |a Analysis of anatomical location, mitoses, and Ki-67 in 2608 meningiomas |c Anders Broechner, MD, Andrea Daniela Maier, MD, PhD, Christian Mirian, MD, PhD, Felix Sahm, Prof., Dr Med, Stefan Hamelmann, PhD, Miriam Ratliff, MD, Nima Etminan, Prof., Dr Med, Christel Herold-Mende, Prof., Dr Med, Sandro Krieg, Prof., Dr Med, Andreas von Deimling, MD, Sybren L.N. Maas, MD, PhD, Eelke M. Bos, MD, PhD, Tiit Mathiesen, Prof., Dr Med |
| 246 | 3 | 0 | |a sixtyseven |
| 264 | 1 | |c 20 November 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Veröffentlicht: 20. November 2025 | ||
| 500 | |a Gesehen am 28.01.2026 | ||
| 520 | |a Ki-67 proliferation index (PI) and mitoses are frequent histopathological proliferation markers in meningioma diagnostics. They are used extensively in grading, with mitotic count constituting the major grading criterion in meningiomas but their mutual correlations and associations with phenotypic characteristics are incompletely known. We addressed this by investigating a large retrospective meningioma cohort. We investigated global Ki-67, Ki-67 hotspots, and mitoses, and their associations with WHO grades, histological subtypes, and anatomical locations in 2608 meningiomas from Heidelberg and Mannheim University Hospitals in Germany. As expected, higher WHO grades and inherent subtypes had higher proliferation indices although the variance was high. The transitional subtype had higher proliferation indices than other grade 1 histologies. Skull base meningiomas had significantly lower global Ki-67 PI compared to convexity meningiomas also when stratified for WHO grade. Focal increases of Ki-67, here dubbed hotspots morphology, were more prevalent in higher WHO grades, indicating potential aggressive tumor subclones. Utilizing K-means clustering on paired Ki-67 PIs and mitoses improved alignment with WHO grades. Our analysis identified a heterogenous group of tumors in which certain locations and subtypes were associated with increased Ki-67 PI. They suggests that considering both mitoses and Ki-67 indices improves alignment with WHO grade. | ||
| 700 | 1 | |a Maier, Andrea Daniela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mirian, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sahm, Felix |d 1984- |e VerfasserIn |0 (DE-588)1022852132 |0 (DE-627)717318478 |0 (DE-576)366075020 |4 aut | |
| 700 | 1 | |a Hamelmann, Stefan |d 1990- |e VerfasserIn |0 (DE-588)1236151240 |0 (DE-627)1761335057 |4 aut | |
| 700 | 1 | |a Ratliff, Miriam |d 1979- |e VerfasserIn |0 (DE-588)1012081028 |0 (DE-627)660894602 |0 (DE-576)344899357 |4 aut | |
| 700 | 1 | |a Etminan, Nima |d 1978- |e VerfasserIn |0 (DE-588)134245202 |0 (DE-627)56561374X |0 (DE-576)300399871 |4 aut | |
| 700 | 1 | |a Herold-Mende, Christel |e VerfasserIn |0 (DE-588)1022936549 |0 (DE-627)717335577 |0 (DE-576)366194267 |4 aut | |
| 700 | 1 | |a Krieg, Sandro |d 1982- |e VerfasserIn |0 (DE-588)14001649X |0 (DE-627)703539132 |0 (DE-576)314196935 |4 aut | |
| 700 | 1 | |a Deimling, Andreas von |d 1959- |e VerfasserIn |0 (DE-588)103034115X |0 (DE-627)735093946 |0 (DE-576)378138065 |4 aut | |
| 700 | 1 | |a Maas, Sybren L N |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bos, Eelke M |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mathiesen, Tiit |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neuropathology and experimental neurology |d Oxford : Oxford University Press, 1942 |g (2025), Artikel-ID nlaf131, Seite 1-14 |h Online-Ressource |w (DE-627)324958501 |w (DE-600)2033048-0 |w (DE-576)094400687 |x 1554-6578 |7 nnas |a Analysis of anatomical location, mitoses, and Ki-67 in 2608 meningiomas |
| 773 | 1 | 8 | |g year:2025 |g elocationid:nlaf131 |g pages:1-14 |g extent:14 |a Analysis of anatomical location, mitoses, and Ki-67 in 2608 meningiomas |
| 856 | 4 | 0 | |u https://doi.org/10.1093/jnen/nlaf131 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |7 1 |
| 951 | |a AR | ||
| 992 | |a 20260128 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 103034115X |a Deimling, Andreas von |m 103034115X:Deimling, Andreas von |d 910000 |d 912000 |e 910000PD103034115X |e 912000PD103034115X |k 0/910000/ |k 1/910000/912000/ |p 10 | ||
| 998 | |g 14001649X |a Krieg, Sandro |m 14001649X:Krieg, Sandro |d 910000 |d 911200 |e 910000PK14001649X |e 911200PK14001649X |k 0/910000/ |k 1/910000/911200/ |p 9 | ||
| 998 | |g 1022936549 |a Herold-Mende, Christel |m 1022936549:Herold-Mende, Christel |d 910000 |d 911200 |e 910000PH1022936549 |e 911200PH1022936549 |k 0/910000/ |k 1/910000/911200/ |p 8 | ||
| 998 | |g 134245202 |a Etminan, Nima |m 134245202:Etminan, Nima |d 60000 |d 62600 |e 60000PE134245202 |e 62600PE134245202 |k 0/60000/ |k 1/60000/62600/ |p 7 | ||
| 998 | |g 1012081028 |a Ratliff, Miriam |m 1012081028:Ratliff, Miriam |d 60000 |d 62600 |d 60000 |e 60000PR1012081028 |e 62600PR1012081028 |e 60000PR1012081028 |k 0/60000/ |k 1/60000/62600/ |k 0/60000/ |p 6 | ||
| 998 | |g 1236151240 |a Hamelmann, Stefan |m 1236151240:Hamelmann, Stefan |d 910000 |d 912000 |e 910000PH1236151240 |e 912000PH1236151240 |k 0/910000/ |k 1/910000/912000/ |p 5 | ||
| 998 | |g 1022852132 |a Sahm, Felix |m 1022852132:Sahm, Felix |d 910000 |d 912000 |e 910000PS1022852132 |e 912000PS1022852132 |k 0/910000/ |k 1/910000/912000/ |p 4 | ||
| 999 | |a KXP-PPN1950496384 |e 4863119003 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Anders Broechner, MD, Andrea Daniela Maier, MD, PhD, Christian Mirian, MD, PhD, Felix Sahm, Prof., Dr Med, Stefan Hamelmann, PhD, Miriam Ratliff, MD, Nima Etminan, Prof., Dr Med, Christel Herold-Mende, Prof., Dr Med, Sandro Krieg, Prof., Dr Med, Andreas von Deimling, MD, Sybren L.N. Maas, MD, PhD, Eelke M. Bos, MD, PhD, Tiit Mathiesen, Prof., Dr Med"]},"title":[{"title_sort":"Analysis of anatomical location, mitoses, and Ki-67 in 2608 meningiomas","title":"Analysis of anatomical location, mitoses, and Ki-67 in 2608 meningiomas"}],"origin":[{"dateIssuedDisp":"20 November 2025","dateIssuedKey":"2025"}],"id":{"doi":["10.1093/jnen/nlaf131"],"eki":["1950496384"]},"person":[{"role":"aut","display":"Broechner, Anders","family":"Broechner","given":"Anders"},{"role":"aut","display":"Maier, Andrea Daniela","family":"Maier","given":"Andrea Daniela"},{"given":"Christian","family":"Mirian","display":"Mirian, Christian","role":"aut"},{"given":"Felix","role":"aut","display":"Sahm, Felix","family":"Sahm"},{"family":"Hamelmann","role":"aut","display":"Hamelmann, Stefan","given":"Stefan"},{"role":"aut","display":"Ratliff, Miriam","family":"Ratliff","given":"Miriam"},{"family":"Etminan","role":"aut","display":"Etminan, Nima","given":"Nima"},{"display":"Herold-Mende, Christel","role":"aut","family":"Herold-Mende","given":"Christel"},{"given":"Sandro","family":"Krieg","display":"Krieg, Sandro","role":"aut"},{"given":"Andreas von","family":"Deimling","display":"Deimling, Andreas von","role":"aut"},{"given":"Sybren L N","family":"Maas","role":"aut","display":"Maas, Sybren L N"},{"given":"Eelke M","family":"Bos","role":"aut","display":"Bos, Eelke M"},{"given":"Tiit","role":"aut","display":"Mathiesen, Tiit","family":"Mathiesen"}],"note":["Veröffentlicht: 20. November 2025","Gesehen am 28.01.2026"],"language":["eng"],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"Journal of neuropathology & experimental neurology"}],"note":["Gesehen am 11. Mai 2016"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"324958501","title":[{"subtitle":"official journal of the American Association of Neuropathologists","title_sort":"Journal of neuropathology and experimental neurology","title":"Journal of neuropathology and experimental neurology"}],"disp":"Analysis of anatomical location, mitoses, and Ki-67 in 2608 meningiomasJournal of neuropathology and experimental neurology","origin":[{"dateIssuedDisp":"1942-","publisher":"Oxford University Press ; Ovid ; Lippincott Williams & Wilkins ; Allen Press","publisherPlace":"Oxford ; [Erscheinungsort nicht ermittelbar] ; Philadelphia, Pa. [u.a.] ; Lawrence, Kan.","dateIssuedKey":"1942"}],"id":{"zdb":["2033048-0"],"eki":["324958501"],"issn":["1554-6578"]},"part":{"pages":"1-14","extent":"14","text":"(2025), Artikel-ID nlaf131, Seite 1-14","year":"2025"},"pubHistory":["1.1942 -"],"language":["eng"]}],"physDesc":[{"noteIll":"Illustrationen","extent":"14 S."}],"recId":"1950496384"} | ||
| SRT | |a BROECHNERAANALYSISOF2020 | ||